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Gene Review

LAP3  -  Lap3p

Saccharomyces cerevisiae S288c

Synonyms: BLH1, BLM hydrolase, Bleomycin hydrolase, Cysteine proteinase 1, mitochondrial, GAL6, ...
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Disease relevance of LAP3


High impact information on LAP3


Chemical compound and disease context of LAP3

  • Variant Gal6 proteins that fail to bind nucleic acid also exhibit reduced ability to protect cells from bleomycin toxicity, suggesting that the nucleic acid binding activity of Gal6p is important in bleomycin detoxification and may be involved in its normal biological functions [8].
  • Protective mechanisms against homocysteine toxicity: the role of bleomycin hydrolase [9].

Biological context of LAP3


Anatomical context of LAP3


Associations of LAP3 with chemical compounds


Other interactions of LAP3

  • The GAL6 deletion does not affect the expression of another inducible gene, HSP26 [10].
  • The results suggest a major role of Imp2 in a GAL6-independent pathway [18].
  • The role of the proteins encoded by the GAL80 gene, the MIG1 gene and the GAL6 gene in glucose control of galactose consumption by Saccharomyces cerevisiae was studied by physiological characterisation of various GAL mutant strains [12].

Analytical, diagnostic and therapeutic context of LAP3


  1. Yeast bleomycin hydrolase is a DNA-binding cysteine protease. Identification, purification, biochemical characterization. Xu, H.E., Johnston, S.A. J. Biol. Chem. (1994) [Pubmed]
  2. Noncovalent complexes between the lysosomal proteinase cathepsin B and its propeptide account for stable, extracellular, high molecular mass forms of the enzyme. Mach, L., Mort, J.S., Glössl, J. J. Biol. Chem. (1994) [Pubmed]
  3. Cys102 and His398 are required for bleomycin-inactivating activity but not for hexamer formation of yeast bleomycin hydrolase. Pei, Z., Sebti, S.M. Biochemistry (1996) [Pubmed]
  4. Gene cloning and characterization of PepC, a cysteine aminopeptidase from Streptococcus thermophilus, with sequence similarity to the eucaryotic bleomycin hydrolase. Chapot-Chartier, M.P., Rul, F., Nardi, M., Gripon, J.C. Eur. J. Biochem. (1994) [Pubmed]
  5. Short report: Immunodiagnosis of human fascioliasis using recombinant Fasciola hepatica cathepsin L1 cysteine proteinase. O'Neill, S.M., Parkinson, M., Dowd, A.J., Strauss, W., Angles, R., Dalton, J.P. Am. J. Trop. Med. Hyg. (1999) [Pubmed]
  6. The unusual active site of Gal6/bleomycin hydrolase can act as a carboxypeptidase, aminopeptidase, and peptide ligase. Zheng, W., Johnston, S.A., Joshua-Tor, L. Cell (1998) [Pubmed]
  7. Crystal structure of a conserved protease that binds DNA: the bleomycin hydrolase, Gal6. Joshua-Tor, L., Xu, H.E., Johnston, S.A., Rees, D.C. Science (1995) [Pubmed]
  8. The nucleic acid binding activity of bleomycin hydrolase is involved in bleomycin detoxification. Zheng, W., Johnston, S.A. Mol. Cell. Biol. (1998) [Pubmed]
  9. Protective mechanisms against homocysteine toxicity: the role of bleomycin hydrolase. Zimny, J., Sikora, M., Guranowski, A., Jakubowski, H. J. Biol. Chem. (2006) [Pubmed]
  10. The cysteine-peptidase bleomycin hydrolase is a member of the galactose regulon in yeast. Zheng, W., Xu, H.E., Johnston, S.A. J. Biol. Chem. (1997) [Pubmed]
  11. A yeast gene (BLH1) encodes a polypeptide with high homology to vertebrate bleomycin hydrolase, a family member of thiol proteinases. Magdolen, U., Müller, G., Magdolen, V., Bandlow, W. Biochim. Biophys. Acta (1993) [Pubmed]
  12. The impact of GAL6, GAL80, and MIG1 on glucose control of the GAL system in Saccharomyces cerevisiae. Ostergaard, S., Walløe, K.O., Gomes, S.G., Olsson, L., Nielsen, J. FEMS Yeast Res. (2001) [Pubmed]
  13. BLH1 codes for a yeast thiol aminopeptidase, the equivalent of mammalian bleomycin hydrolase. Enenkel, C., Wolf, D.H. J. Biol. Chem. (1993) [Pubmed]
  14. Yeast cysteine proteinase gene ycp1 induces resistance to bleomycin in mammalian cells. Pei, Z., Calmels, T.P., Creutz, C.E., Sebti, S.M. Mol. Pharmacol. (1995) [Pubmed]
  15. Bleomycin hydrolase (Blh1p), a multi-sited thiol protease in search of a distinct physiological role. Niemer, I., Müller, G., Strobel, G., Bandlow, W. Curr. Genet. (1997) [Pubmed]
  16. Rab5-associated vacuoles play a unique role in phagocytosis of the enteric protozoan parasite Entamoeba histolytica. Saito-Nakano, Y., Yasuda, T., Nakada-Tsukui, K., Leippe, M., Nozaki, T. J. Biol. Chem. (2004) [Pubmed]
  17. Molecular cloning, sequencing, expression of Chinese sturgeon cystatin in yeast Pichia pastoris and its proteinase inhibitory activity. Bai, J., Ma, D., Lao, H., Jian, Q., Ye, X., Luo, J., Xong, X., Li, Y., Liang, X. J. Biotechnol. (2006) [Pubmed]
  18. MIG1-dependent and MIG1-independent regulation of GAL gene expression in Saccharomyces cerevisiae: role of Imp2p. Alberti, A., Lodi, T., Ferrero, I., Donnini, C. Yeast (2003) [Pubmed]
  19. Cysteine proteinase of Entamoeba histolytica. I. Partial purification and action on different enzymes. Scholze, H., Werries, E. Mol. Biochem. Parasitol. (1986) [Pubmed]
  20. Characterization and large-scale expression of the recombinant cysteine proteinase from adult Clonorchis sinensis. Park, S.Y., Lee, K.H., Hwang, Y.B., Kim, K.Y., Park, S.K., Hwang, H.A., Sakanari, J.A., Hong, K.M., Kim, S.I., Park, H. J. Parasitol. (2001) [Pubmed]
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