Gene Review:
BLMH - bleomycin hydrolase
Homo sapiens
Synonyms:
BH, BLM hydrolase, BMH, Bleomycin hydrolase
- Genomic structure and genetic mapping of the human neutral cysteine protease bleomycin hydrolase. Montoya, S.E., Ferrell, R.E., Lazo, J.S. Cancer Res. (1997)
- Cloning and expression analysis of human bleomycin hydrolase, a cysteine proteinase involved in chemotherapy resistance. Ferrando, A.A., Velasco, G., Campo, E., Lopez-Otin, C. Cancer Res. (1996)
- Gene characterization, promoter analysis, and chromosomal localization of human bleomycin hydrolase. Ferrando, A.A., Pendás, A.M., Llano, E., Velasco, G., Lidereau, R., López-Otín, C. J. Biol. Chem. (1997)
- Association between bleomycin hydrolase and Alzheimer's disease in caucasians. Farrer, L.A., Abraham, C.R., Haines, J.L., Rogaeva, E.A., Song, Y., McGraw, W.T., Brindle, N., Premkumar, S., Scott, W.K., Yamaoka, L.H., Saunders, A.M., Roses, A.D., Auerbach, S.A., Sorbi, S., Duara, R., Pericak-Vance, M.A., St George-Hyslop, P.H. Ann. Neurol. (1998)
- Polymorphisms of the human apolipoprotein E promoter and bleomycin hydrolase gene: risk factors for Alzheimer's dementia? Thome, J., Gewirtz, J.C., Sakai, N., Zachariou, V., Retz-Junginger, P., Retz, W., Duman, R.S., Rösler, M. Neurosci. Lett. (1999)
- Bleomycin hydrolase is associated with risk of sporadic Alzheimer's disease. Montoya, S.E., Aston, C.E., DeKosky, S.T., Kamboh, M.I., Lazo, J.S., Ferrell, R.E. Nat. Genet. (1998)
- The unusual active site of Gal6/bleomycin hydrolase can act as a carboxypeptidase, aminopeptidase, and peptide ligase. Zheng, W., Johnston, S.A., Joshua-Tor, L. Cell (1998)
- Characterization of a herpes simplex virus type 1 mutant resistant to benzhydrazone, a selective inhibitor of herpesvirus glycosylation. Tognon, M., Manservigi, R., Cavrini, V., Campadelli-Fiume, G. Proc. Natl. Acad. Sci. U.S.A. (1984)
- Protective mechanisms against homocysteine toxicity: the role of bleomycin hydrolase. Zimny, J., Sikora, M., Guranowski, A., Jakubowski, H. J. Biol. Chem. (2006)
- Identification of duplicated genes in 17q11.2 using FISH on stretched chromosomes and DNA fibers. Bentivegna, A., Venturin, M., Gervasini, C., Corrado, L., Larizza, L., Riva, P. Hum. Genet. (2001)
- Human bleomycin hydrolase binds ribosomal proteins. Koldamova, R.P., Lefterov, I.M., DiSabella, M.T., Almonte, C., Watkins, S.C., Lazo, J.S. Biochemistry (1999)
- Characteristics of bleomycin-resistant phenotypes of human cell sublines and circumvention of bleomycin resistance by liblomycin. Lazo, J.S., Braun, I.D., Labaree, D.C., Schisselbauer, J.C., Meandzija, B., Newman, R.A., Kennedy, K.A. Cancer Res. (1989)
- The C-terminus of human bleomycin hydrolase is required for protection against bleomycin-induced chromosomal damage. Lefterov, I.M., Koldamova, R.P., King, J., Lazo, J.S. Mutat. Res. (1998)
- Bleomycin hydrolase immunoreactivity in senile plaque in the brains of patients with Alzheimer's disease. Namba, Y., Ouchi, Y., Takeda, A., Ueki, A., Ikeda, K. Brain Res. (1999)
- Further characterization of bleomycin-resistant HeLa cells and analysis of resistance mechanism. Urade, M., Sugi, M., Matsuya, T. Jpn. J. Cancer Res. (1988)
- Human bleomycin hydrolase regulates the secretion of amyloid precursor protein. Lefterov, I.M., Koldamova, R.P., Lazo, J.S. FASEB J. (2000)
- An evolutionarily conserved cysteine protease, human bleomycin hydrolase, binds to the human homologue of ubiquitin-conjugating enzyme 9. Koldamova, R.P., Lefterov, I.M., DiSabella, M.T., Lazo, J.S. Mol. Pharmacol. (1998)
- Cysteine 73 in bleomycin hydrolase is critical for amyloid precursor protein processing. Lefterov, I.M., Koldamova, R.P., Lefterova, M.I., Schwartz, D.R., Lazo, J.S. Biochem. Biophys. Res. Commun. (2001)
- Lidocaine potentiation of bleomycin A2 cytotoxicity and DNA strand breakage in L1210 and human A-253 cells. Lazo, J.S., Braun, I.D., Meandzija, B., Kennedy, K.A., Pham, E.T., Smaldone, L.F. Cancer Res. (1985)
- Induction of bleomycin resistance in a human oral squamous carcinoma cell line and characterisation of bleomycin-resistant and -sensitive clones. Urade, M., Ogura, T., Uematsu, T., Takahashi, Y., Kishimoto, H., Yoshioka, W. Eur. J. Cancer, B, Oral Oncol. (1994)
- Human bleomycin hydrolase: molecular cloning, sequencing, functional expression, and enzymatic characterization. Brömme, D., Rossi, A.B., Smeekens, S.P., Anderson, D.C., Payan, D.G. Biochemistry (1996)
- Essential binding and functional domains of human bleomycin hydrolase. Koldamova, R.P., Lefterov, I.M., Gadjeva, V.G., Lazo, J.S. Biochemistry (1998)
- Regional and cellular distribution of bleomycin hydrolase mRNA in human brain: comparison between Alzheimer's diseased and control brains. Malherbe, P., Faull, R.L., Richards, J.G. Neurosci. Lett. (2000)
- Metabolic inactivation: a mechanism of human tumor resistance to bleomycin. Sebti, S.M., Jani, J.P., Mistry, J.S., Gorelik, E., Lazo, J.S. Cancer Res. (1991)