Disease relevance of Aqp7

• It is likely that up-regulated expression of AQP2 mRNA and down-regulated expression of AQP7 mRNA in the rat inner ear caused by vasopressin induce an increased production and a decreased absorption of endolymph, resulting in endolymphatic hydrops [1].

High impact information on Aqp7

• In addition, epididymal epithelial cells express significant amounts of the mRNAs coding for AQP7 and 11 [2].
• AQP8 mRNA was found in testis but not in epididymis, whereas the AQP7 transcript was present in both locations [3].
• AQP7 appeared as a 23- to 24-kDa band and was found both in testis and epididymis [3].
• AQP7 was present in spermatids and spermatozoa and was predominant over the plasma membrane [3].
• Here, potential roles for AQP7 and AQP8, two aquaporin water channels abundantly expressed in the MR tract, were investigated by studying their expression and distribution in the developing testis of the Wistar rat [4].

Biological context of Aqp7

• Possible involvement of aquaporin-7 and -8 in rat testis development and spermatogenesis [4].

Anatomical context of Aqp7

• Immunohistochemical analyses demonstrated AQP7 in elongated spermatids, testicular spermatozoa, and residual bodies at P45 with increased signal intensity thereafter [4].
• Expression and immunolocalization of aquaporin-7 in rat gastrointestinal tract [5].
• The higher expression of AQP7 protein at the apical pole of the superficial epithelial cells suggests its involvement in rapid fluid movement through the villus epithelium [5].
• CONCLUSIONS: The results indicate that AQP7 is present in the small and large intestine [5].
• RESULTS: AQP7 mRNA and proteins were highly expressed in the small intestine, weakly in the caecum, colon and rectum and were absent in the stomach [5].

Associations of Aqp7 with chemical compounds

• RT-PCR on microdissected nephron segments revealed AQP7 mRNA in proximal convoluted and straight tubules [6].

Other interactions of Aqp7

• The ontogeny and distribution of AQP7 and AQP8 in rat testis suggest involvement in major physiologic changes in testis development and spermatogenesis [4].
• The AQP-7 mRNA increased on postoperative day 3, but the AQP-4 mRNA did not change after the bowel resection [7].

Analytical, diagnostic and therapeutic context of Aqp7

• By semiquantitative RT-PCR and immunoblotting, first expression of AQP7 was noted at postnatal day 45 (P45), with levels increasing substantially at P90 and remaining at high levels thereafter [4].
• Immunohistochemistry revealed strong AQP7 labelling in the surface epithelial cells of duodenum, jejunum, ileum, caecum, colon and rectum, whereas weak or no labelling was observed in the crypt cells [5].
• RT-PCR of rat and mouse kidney zones revealed AQP7 mRNA in cortex and outer stripe of the outer medulla [6].

References