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Gene Review

AQP7  -  aquaporin 7

Homo sapiens

Synonyms: AQP-7, AQP7L, AQP9, AQPap, Aquaglyceroporin-7, ...
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Disease relevance of AQP7

  • Recent studies have shown that the absence of AQP7 expression in fat cells increases glycerol kinase activity, boosting triacylglycerol synthesis and ultimately leading to obesity [1].
  • It is likely that up-regulated expression of AQP2 mRNA and down-regulated expression of AQP7 mRNA in the rat inner ear caused by vasopressin induce an increased production and a decreased absorption of endolymph, resulting in endolymphatic hydrops [2].
  • Much further work is needed to define whether the overexpression of AQP9 plays a direct role either in the pathogenesis or in the adaptative response of preeclampsia [3].
  • Furthermore, a lack of AQP7 expression in sperm may be an underlying mechanism of male infertility [4].
  • Furthermore, after transient brain ischemia, AQP9 expression is increased in astrocytes and its regulation may implicate the MAP-kinase pathways stimulated in such pathological conditions [5].

Psychiatry related information on AQP7


High impact information on AQP7

  • Multifunctional aquaglyceroporins AQP3, AQP7, and AQP9 are permeated by water, glycerol, and some other solutes [7].
  • In mammals, there are currently 10 families of water channels, referred to as aquaporins (AQP): AQP0-AQP9 [8].
  • We report that two members of the aquaporin family, AQP3 and AQP7, are expressed in immature DCs and are downregulated after maturation [9].
  • Little AQP7 or AQP9 mRNA was detected by reverse transcription-PCR in either cell line, whereas AQP3 mRNA expression was 2-fold lower in R15 cells than in CL3 cells [10].
  • Surprisingly, several PPARgamma target genes were up-regulated in PAX8-PPARgamma-positive FTCs such as angiopoietin-like 4 and aquaporin 7 [11].

Chemical compound and disease context of AQP7


Biological context of AQP7

  • A 1408 bp cDNA was sequenced (designated rAQP9L) with a 885 bp open reading frame encoding a 295 amino acid hydrophobic protein. rAQP9L has the greatest amino-acid sequence identity with human AQP9 (75%) and a less homology with AQP3 (49%) and AQP7 (47%) [13].
  • These results suggest that the increase of urea uptake in preeclamptic pregnancies could be attributed to an increase of expression of UT-A more than AQP9 proteins [3].
  • The large discrepancy of tissue distribution between hAQP9 and rAQP9L suggest that rAQP9L is a new aquaporin, which is involved in transport of urea as well as water in liver [13].
  • AQP7 may be involved in the maintenance of sperm motility [4].
  • PURPOSE: We have previously reported the expression of aquaporin-7 (AQP7) in the rat testis and cloned human AQP7 from the testicular cDNA library [4].

Anatomical context of AQP7


Associations of AQP7 with chemical compounds


Other interactions of AQP7


Analytical, diagnostic and therapeutic context of AQP7


  1. Aquaporin-7 and glycerol permeability as novel obesity drug-target pathways. Frühbeck, G., Catalán, V., Gómez-Ambrosi, J., Rodríguez, A. Trends Pharmacol. Sci. (2006) [Pubmed]
  2. Effects of vasopressin on gene expression in rat inner ear. Gu, F.M., Han, H.L., Zhang, L.S. Hear. Res. (2006) [Pubmed]
  3. Functional and Molecular Expression of AQP9 Channel and UT-A Transporter in Normal and Preeclamptic Human Placentas. Damiano, A.E., Zotta, E., Ibarra, C. Placenta (2006) [Pubmed]
  4. Localization of aquaporin-7 in human testis and ejaculated sperm: possible involvement in maintenance of sperm quality. Saito, K., Kageyama, Y., Okada, Y., Kawakami, S., Kihara, K., Ishibashi, K., Sasaki, S. J. Urol. (2004) [Pubmed]
  5. Distribution and possible roles of aquaporin 9 in the brain. Badaut, J., Regli, L. Neuroscience (2004) [Pubmed]
  6. Differential expression of aquaporin 7 in adipose tissue of lean and obese high fat consumers. Marrades, M.P., Milagro, F.I., Martínez, J.A., Moreno-Aliaga, M.J. Biochem. Biophys. Res. Commun. (2006) [Pubmed]
  7. Cellular and molecular biology of the aquaporin water channels. Borgnia, M., Nielsen, S., Engel, A., Agre, P. Annu. Rev. Biochem. (1999) [Pubmed]
  8. Structural basis of water-specific transport through the AQP1 water channel. Sui, H., Han, B.G., Lee, J.K., Walian, P., Jap, B.K. Nature (2001) [Pubmed]
  9. The role of aquaporins in dendritic cell macropinocytosis. de Baey, A., Lanzavecchia, A. J. Exp. Med. (2000) [Pubmed]
  10. Enhanced expression of multidrug resistance-associated protein 2 and reduced expression of aquaglyceroporin 3 in an arsenic-resistant human cell line. Lee, T.C., Ho, I.C., Lu, W.J., Huang, J.D. J. Biol. Chem. (2006) [Pubmed]
  11. Follicular thyroid tumors with the PAX8-PPARgamma1 rearrangement display characteristic genetic alterations. Lacroix, L., Lazar, V., Michiels, S., Ripoche, H., Dessen, P., Talbot, M., Caillou, B., Levillain, J.P., Schlumberger, M., Bidart, J.M. Am. J. Pathol. (2005) [Pubmed]
  12. The effects of thiazolidinedione treatment on the regulations of aquaglyceroporins and glycerol kinase in OLETF rats. Lee, D.H., Park, D.B., Lee, Y.K., An, C.S., Oh, Y.S., Kang, J.S., Kang, S.H., Chung, M.Y. Metab. Clin. Exp. (2005) [Pubmed]
  13. Cloning and functional expression of rAOP9L a new member of aquaporin family from rat liver. Ko, S.B., Uchida, S., Naruse, S., Kuwahara, M., Ishibashi, K., Marumo, F., Hayakawa, T., Sasaki, S. Biochem. Mol. Biol. Int. (1999) [Pubmed]
  14. Aquaporins (water channels): role in vasopressin-activated water transport. Dibas, A.I., Mia, A.J., Yorio, T. Proc. Soc. Exp. Biol. Med. (1998) [Pubmed]
  15. Aquaporins: water channel proteins of the cell membrane. Takata, K., Matsuzaki, T., Tajika, Y. Progress in histochemistry and cytochemistry. (2004) [Pubmed]
  16. Cloning and functional expression of a new water channel abundantly expressed in the testis permeable to water, glycerol, and urea. Ishibashi, K., Kuwahara, M., Gu, Y., Kageyama, Y., Tohsaka, A., Suzuki, F., Marumo, F., Sasaki, S. J. Biol. Chem. (1997) [Pubmed]
  17. Adipose tissue expression of the glycerol channel aquaporin-7 gene is altered in severe obesity but not in type 2 diabetes. Ceperuelo-Mallafré, V., Miranda, M., Chacón, M.R., Vilarrasa, N., Megia, A., Gutiérrez, C., Fernández-Real, J.M., Gómez, J.M., Caubet, E., Frühbeck, G., Vendrell, J. J. Clin. Endocrinol. Metab. (2007) [Pubmed]
  18. Altered expression of aquaporins in bullous keratopathy and Fuchs' dystrophy corneas. Kenney, M.C., Atilano, S.R., Zorapapel, N., Holguin, B., Gaster, R.N., Ljubimov, A.V. J. Histochem. Cytochem. (2004) [Pubmed]
  19. Expression and localization of aquaporin 7 in normal skeletal myofiber. Wakayama, Y., Inoue, M., Kojima, H., Jimi, T., Shibuya, S., Hara, H., Oniki, H. Cell Tissue Res. (2004) [Pubmed]
  20. Arsenic trioxide uptake by human and rat aquaglyceroporins. Liu, Z., Carbrey, J.M., Agre, P., Rosen, B.P. Biochem. Biophys. Res. Commun. (2004) [Pubmed]
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