Chemical Compound Review:
Ozone/NNK N-methyl-N-(4-oxo-4-pyridin- 3-yl...
Synonyms:
AGN-PC-00MHF7, CCRIS 1150, AG-G-40133, AG-G-40136, CHEMBL2311069, ...
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- Elevated 8-hydroxy-2'-deoxyguanosine levels in lung DNA of A/J mice and F344 rats treated with 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone and inhibition by dietary 1,4-phenylenebis(methylene)selenocyanate. Rosa, J.G., Prokopczyk, B., Desai, D.H., Amin, S.G., El-Bayoumy, K. Carcinogenesis (1998)
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- Antimutagenicity of cyclohexanol towards 4-(N-nitrosomethylamino)-1-(3-pyridyl)-1-butanone and N-nitrosodiethylamine in Salmonella typhimurium strain TA100. Espinosa-Aguirre, J.J., Vilchis, C., Ostrosky-Wegman, P., Benitez, L., Lares, I., Rubio, J. Mutat. Res. (1993)
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- Metabolism and DNA damage induced by 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone in fetal tissues of the Syrian golden hamster. Rossignol, G., Alaoui-Jamali, M.A., Castonguay, A., Schuller, H.M. Cancer Res. (1989)
- Structure-activity relationships for inhibition of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone lung tumorigenesis by arylalkyl isothiocyanates in A/J mice. Morse, M.A., Eklind, K.I., Hecht, S.S., Jordan, K.G., Choi, C.I., Desai, D.H., Amin, S.G., Chung, F.L. Cancer Res. (1991)
- Metabolic activation of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone as measured by DNA alkylation in vitro and its inhibition by isothiocyanates. Guo, Z., Smith, T.J., Thomas, P.E., Yang, C.S. Cancer Res. (1991)
- Tobacco carcinogen-induced cellular transformation increases activation of the phosphatidylinositol 3'-kinase/Akt pathway in vitro and in vivo. West, K.A., Linnoila, I.R., Belinsky, S.A., Harris, C.C., Dennis, P.A. Cancer Res. (2004)
- Metabolism and DNA single strand breaks induced by 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone and its analogues in primary culture of rat hepatocytes. Liu, L.L., Alaoui-Jamali, M.A., el Alami, N., Castonguay, A. Cancer Res. (1990)
- Correlation between UDP-glucuronosyltransferase genotypes and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone glucuronidation phenotype in human liver microsomes. Wiener, D., Fang, J.L., Dossett, N., Lazarus, P. Cancer Res. (2004)
- Biomarkers for human uptake and metabolic activation of tobacco-specific nitrosamines. Hecht, S.S., Carmella, S.G., Foiles, P.G., Murphy, S.E. Cancer Res. (1994)
- Evidence for an important role of DNA pyridyloxobutylation in rat lung carcinogenesis by 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone: effects of dose and phenethyl isothiocyanate. Staretz, M.E., Foiles, P.G., Miglietta, L.M., Hecht, S.S. Cancer Res. (1997)
- Induction of lung and exocrine pancreas tumors in F344 rats by tobacco-specific and Areca-derived N-nitrosamines. Rivenson, A., Hoffmann, D., Prokopczyk, B., Amin, S., Hecht, S.S. Cancer Res. (1988)
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- Effects of indole-3-carbinol on lung tumorigenesis and DNA methylation induced by 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) and on the metabolism and disposition of NNK in A/J mice. Morse, M.A., LaGreca, S.D., Amin, S.G., Chung, F.L. Cancer Res. (1990)
- Human cytochrome P450 CYP2A13: predominant expression in the respiratory tract and its high efficiency metabolic activation of a tobacco-specific carcinogen, 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone. Su, T., Bao, Z., Zhang, Q.Y., Smith, T.J., Hong, J.Y., Ding, X. Cancer Res. (2000)
- Human CYP2A6 activation of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK): mutational specificity in the gpt gene of AS52 cells. Tiano, H.F., Wang, R.L., Hosokawa, M., Crespi, C., Tindall, K.R., Langenbach, R. Carcinogenesis (1994)
- A tobacco smoke-derived nitrosamine, 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone, is activated by multiple human cytochrome P450s including the polymorphic human cytochrome P4502D6. Crespi, C.L., Penman, B.W., Gelboin, H.V., Gonzalez, F.J. Carcinogenesis (1991)
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- SPRR1B overexpression enhances entry of cells into the G0 phase of the cell cycle. Tesfaigzi, Y., Wright, P.S., Belinsky, S.A. Am. J. Physiol. Lung Cell Mol. Physiol. (2003)
- Perinatal metabolism of the tobacco-specific carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone in C57BL mice. Castonguay, A., Tjälve, H., Trushin, N., Hecht, S.S. J. Natl. Cancer Inst. (1984)
- Recovery from 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-induced immunosuppression in A/J mice by treatment with nonsteroidal anti-inflammatory drugs. Rioux, N., Castonguay, A. J. Natl. Cancer Inst. (1997)
- A study of tobacco carcinogenesis: effect of the fat content of the diet on the carcinogenic activity of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone in F344 rats. Hoffmann, D., Rivenson, A., Abbi, R., Wynder, E.L. Cancer Res. (1993)
- Tissue distribution of the tobacco-specific carcinogen 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone and its metabolites in F344 rats. Castonguay, A., Tjälve, H., Hecht, S.S. Cancer Res. (1983)
- Automated in-tube solid-phase microextraction coupled with HPLC for the determination of N-nitrosamines in cell cultures. Mullett, W.M., Levsen, K., Borlak, J., Wu, J., Pawliszyn, J. Anal. Chem. (2002)