Gene Review:
CYP51A1 - cytochrome P450, family 51, subfamily A,...
Homo sapiens
Synonyms:
CP51, CYP51, CYPL1, CYPLI, Cytochrome P450 51A1, ...
- The ubiquitously expressed human CYP51 encodes lanosterol 14 alpha-demethylase, a cytochrome P450 whose expression is regulated by oxysterols. Strömstedt, M., Rozman, D., Waterman, M.R. Arch. Biochem. Biophys. (1996)
- CYP51 from Trypanosoma cruzi: a phyla-specific residue in the B' helix defines substrate preferences of sterol 14alpha-demethylase. Lepesheva, G.I., Zaitseva, N.G., Nes, W.D., Zhou, W., Arase, M., Liu, J., Hill, G.C., Waterman, M.R. J. Biol. Chem. (2006)
- Sex differences in the effect of diabetes duration on coronary heart disease mortality. Natarajan, S., Liao, Y., Sinha, D., Cao, G., McGee, D.L., Lipsitz, S.R. Arch. Intern. Med. (2005)
- Role of glucose transporters in the cellular insulin resistance of type II non-insulin-dependent diabetes mellitus. Garvey, W.T., Huecksteadt, T.P., Matthaei, S., Olefsky, J.M. J. Clin. Invest. (1988)
- A different function for a member of an ancient and highly conserved cytochrome P450 family: From essential sterols to plant defense. Qi, X., Bakht, S., Qin, B., Leggett, M., Hemmings, A., Mellon, F., Eagles, J., Werck-Reichhart, D., Schaller, H., Lesot, A., Melton, R., Osbourn, A. Proc. Natl. Acad. Sci. U.S.A. (2006)
- Folding requirements are different between sterol 14alpha-demethylase (CYP51) from Mycobacterium tuberculosis and human or fungal orthologs. Lepesheva, G.I., Podust, L.M., Bellamine, A., Waterman, M.R. J. Biol. Chem. (2001)
- Conservation and cloning of CYP51: a sterol 14 alpha-demethylase from Mycobacterium smegmatis. Jackson, C.J., Lamb, D.C., Marczylo, T.H., Parker, J.E., Manning, N.L., Kelly, D.E., Kelly, S.L. Biochem. Biophys. Res. Commun. (2003)
- Undetectable maternal serum uE3 and postnatal abnormal sterol and steroid metabolism in Antley-Bixler syndrome. Cragun, D.L., Trumpy, S.K., Shackleton, C.H., Kelley, R.I., Leslie, N.D., Mulrooney, N.P., Hopkin, R.J. Am. J. Med. Genet. A (2004)
- A cAMP-responsive element binding site is essential for sterol regulation of the human lanosterol 14alpha-demethylase gene (CYP51). Halder, S.K., Fink, M., Waterman, M.R., Rozman, D. Mol. Endocrinol. (2002)
- The three human cytochrome P450 lanosterol 14 alpha-demethylase (CYP51) genes reside on chromosomes 3, 7, and 13: structure of the two retrotransposed pseudogenes, association with a line-1 element, and evolution of the human CYP51 family. Rozman, D., Strömstedt, M., Waterman, M.R. Arch. Biochem. Biophys. (1996)
- Cyclic adenosine 3',5'-monophosphate(cAMP)/cAMP-responsive element modulator (CREM)-dependent regulation of cholesterogenic lanosterol 14alpha-demethylase (CYP51) in spermatids. Rozman, D., Fink, M., Fimia, G.M., Sassone-Corsi, P., Waterman, M.R. Mol. Endocrinol. (1999)
- Localisation of lanosterol 14alpha-demethylase in round and elongated spermatids of the mouse testis: an immunoelectron microscopic and stereological study. Cotman, M., Rozma, D., Banek, L., Jezek, D. Pflugers Arch. (2001)
- Amino acid substitutions in the cytochrome P-450 lanosterol 14alpha-demethylase (CYP51A1) from azole-resistant Candida albicans clinical isolates contribute to resistance to azole antifungal agents. Sanglard, D., Ischer, F., Koymans, L., Bille, J. Antimicrob. Agents Chemother. (1998)
- Impact of changes in the target P450 CYP51 enzyme associated with altered triazole-sensitivity in fungal pathogens of cereal crops. Cools, H.J., Fraaije, B.A., Kim, S.H., Lucas, J.A. Biochem. Soc. Trans. (2006)
- Cross-resistance to polyene and azole drugs in Cryptococcus neoformans. Joseph-Horne, T., Hollomon, D., Loeffler, R.S., Kelly, S.L. Antimicrob. Agents Chemother. (1995)
- Cytochrome p450 profile of colorectal cancer: identification of markers of prognosis. Kumarakulasingham, M., Rooney, P.H., Dundas, S.R., Telfer, C., Melvin, W.T., Curran, S., Murray, G.I. Clin. Cancer Res. (2005)
- STUDIES ON THE EXPRESSION LEVELS OF STEROL-METABOLIZING ENZYMES IN THE OBESE MODEL SHR/NDmcr-cp RATS. Kudo, M., Noshiro, M., Aoyama, Y., Yoshida, Y. Clin. Exp. Pharmacol. Physiol. (2004)
- Mammalian cytochromes P450-Importance of tissue specificity. Seliskar, M., Rozman, D. Biochim. Biophys. Acta (2007)
- Biological spectra analysis: Linking biological activity profiles to molecular structure. Fliri, A.F., Loging, W.T., Thadeio, P.F., Volkmann, R.A. Proc. Natl. Acad. Sci. U.S.A. (2005)
- Elevated expression of lanosterol 14alpha-demethylase (CYP51) and the synthesis of oocyte meiosis-activating sterols in postmeiotic germ cells of male rats. Strömstedt, M., Waterman, M.R., Haugen, T.B., Taskén, K., Parvinen, M., Rozman, D. Endocrinology (1998)