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Tiam1  -  T-cell lymphoma invasion and metastasis 1

Rattus norvegicus

 
 
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Disease relevance of Tiam1

 

High impact information on Tiam1

  • Our results indicate that T-lymphoma invasion is driven by Tiam1/Rac or Cdc42 activation, and is dependent on LPA/S1P receptor-mediated RhoA and PLC signaling pathways which lead to pseudopod formation and enhanced infiltration [3].
  • Invasion of T-lymphoma cells into a fibroblast monolayer is induced by Tiam1, an activator of the Rho-like GTPase Rac, and by constitutively active V12Rac1 [3].
  • TrkB binds and tyrosine-phosphorylates Tiam1, leading to activation of Rac1 and induction of changes in cellular morphology [1].
  • A point mutation in Tiam1, Tyr-829 to Phe-829, blocked these BDNF-induced changes in cellular morphology [1].
  • The findings are evidence of a previously uncharacterized mechanism for the activation of Tiam1 and of a role for this effector in neurotrophin-mediated signal transduction leading to changes in cellular morphology [1].
 

Chemical compound and disease context of Tiam1

 

Associations of Tiam1 with chemical compounds

 

Anatomical context of Tiam1

  • Taken together, these results suggest that by regulating growth cone actin organization and allowing microtubule invasion within selected growth cones, Tiam1 promotes axon formation and hence participates in neuronal polarization [4].

References

  1. TrkB binds and tyrosine-phosphorylates Tiam1, leading to activation of Rac1 and induction of changes in cellular morphology. Miyamoto, Y., Yamauchi, J., Tanoue, A., Wu, C., Mobley, W.C. Proc. Natl. Acad. Sci. U.S.A. (2006) [Pubmed]
  2. Ras activation of a Rac1 exchange factor, Tiam1, mediates neurotrophin-3-induced Schwann cell migration. Yamauchi, J., Miyamoto, Y., Tanoue, A., Shooter, E.M., Chan, J.R. Proc. Natl. Acad. Sci. U.S.A. (2005) [Pubmed]
  3. Invasion of T-lymphoma cells: cooperation between Rho family GTPases and lysophospholipid receptor signaling. Stam, J.C., Michiels, F., van der Kammen, R.A., Moolenaar, W.H., Collard, J.G. EMBO J. (1998) [Pubmed]
  4. Evidence for the involvement of Tiam1 in axon formation. Kunda, P., Paglini, G., Quiroga, S., Kosik, K., Caceres, A. J. Neurosci. (2001) [Pubmed]
  5. The Rac1 guanine nucleotide exchange factor Tiam1 mediates EphB receptor-dependent dendritic spine development. Tolias, K.F., Bikoff, J.B., Kane, C.G., Tolias, C.S., Hu, L., Greenberg, M.E. Proc. Natl. Acad. Sci. U.S.A. (2007) [Pubmed]
 
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