The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)



Gene Review

Tiam1  -  T-cell lymphoma invasion and metastasis 1

Rattus norvegicus

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of Tiam1


High impact information on Tiam1

  • Our results indicate that T-lymphoma invasion is driven by Tiam1/Rac or Cdc42 activation, and is dependent on LPA/S1P receptor-mediated RhoA and PLC signaling pathways which lead to pseudopod formation and enhanced infiltration [3].
  • Invasion of T-lymphoma cells into a fibroblast monolayer is induced by Tiam1, an activator of the Rho-like GTPase Rac, and by constitutively active V12Rac1 [3].
  • TrkB binds and tyrosine-phosphorylates Tiam1, leading to activation of Rac1 and induction of changes in cellular morphology [1].
  • A point mutation in Tiam1, Tyr-829 to Phe-829, blocked these BDNF-induced changes in cellular morphology [1].
  • The findings are evidence of a previously uncharacterized mechanism for the activation of Tiam1 and of a role for this effector in neurotrophin-mediated signal transduction leading to changes in cellular morphology [1].

Chemical compound and disease context of Tiam1


Associations of Tiam1 with chemical compounds


Anatomical context of Tiam1

  • Taken together, these results suggest that by regulating growth cone actin organization and allowing microtubule invasion within selected growth cones, Tiam1 promotes axon formation and hence participates in neuronal polarization [4].


  1. TrkB binds and tyrosine-phosphorylates Tiam1, leading to activation of Rac1 and induction of changes in cellular morphology. Miyamoto, Y., Yamauchi, J., Tanoue, A., Wu, C., Mobley, W.C. Proc. Natl. Acad. Sci. U.S.A. (2006) [Pubmed]
  2. Ras activation of a Rac1 exchange factor, Tiam1, mediates neurotrophin-3-induced Schwann cell migration. Yamauchi, J., Miyamoto, Y., Tanoue, A., Shooter, E.M., Chan, J.R. Proc. Natl. Acad. Sci. U.S.A. (2005) [Pubmed]
  3. Invasion of T-lymphoma cells: cooperation between Rho family GTPases and lysophospholipid receptor signaling. Stam, J.C., Michiels, F., van der Kammen, R.A., Moolenaar, W.H., Collard, J.G. EMBO J. (1998) [Pubmed]
  4. Evidence for the involvement of Tiam1 in axon formation. Kunda, P., Paglini, G., Quiroga, S., Kosik, K., Caceres, A. J. Neurosci. (2001) [Pubmed]
  5. The Rac1 guanine nucleotide exchange factor Tiam1 mediates EphB receptor-dependent dendritic spine development. Tolias, K.F., Bikoff, J.B., Kane, C.G., Tolias, C.S., Hu, L., Greenberg, M.E. Proc. Natl. Acad. Sci. U.S.A. (2007) [Pubmed]
WikiGenes - Universities