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HLA-DPA1  -  major histocompatibility complex, class II...

Homo sapiens

Synonyms: DP(W3), DP(W4), HLA class II histocompatibility antigen, DP alpha 1 chain, HLA-DP1A, HLA-SB alpha chain, ...
 
 
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Disease relevance of HLA-DPA1

 

High impact information on HLA-DPA1

 

Biological context of HLA-DPA1

 

Anatomical context of HLA-DPA1

 

Other interactions of HLA-DPA1

  • The Mamu-DPA1 gene is invariant and -DPB1 manifests only moderate allelic variation, whereas the HLA-DPA1 gene is oligomorphic and HLA-DPB1 highly polymorphic [16].
  • Roles of HLA-B, HLA-C and HLA-DPA1 incompatibilities in the outcome of unrelated stem-cell transplantation [12].
  • One hundred and four normal unrelated Chinese were typed for HLA-DPA1 and DPB1 alleles by polymerase chain reaction-restriction fragment length polymorphism [17].
 

Analytical, diagnostic and therapeutic context of HLA-DPA1

  • Thus, PCR-RFLP seems to be one of the best DNA typing methods: it represents direct, accurate, fast, and nonradioactive typing for both HLA-DPA1 and HLA-DPB1 alleles [18].
  • HLA-DPA1 typing by PCR amplification with sequence-specific primers (PCR-SSP) and distribution of DPA1 alleles in Caucasian, African and Oriental populations [19].

References

  1. Investigation of HLA-DPA1 genotypes as predictors of inflammatory bowel disease in the German, South African, and South Korean populations. Lantermann, A., Hampe, J., Kim, W.H., Winter, T.A., Kidd, M., Nagy, M., Fölsch, U.R., Schreiber, S. International journal of colorectal disease. (2002) [Pubmed]
  2. Flow cytometry-based minisequencing: a new platform for high-throughput single-nucleotide polymorphism scoring. Cai, H., White, P.S., Torney, D., Deshpande, A., Wang, Z., Keller, R.A., Marrone, B., Nolan, J.P. Genomics (2000) [Pubmed]
  3. The activation of Langerhans cells in oral lichen planus. Farthing, P.M., Matear, P., Cruchley, A.T. J. Oral Pathol. Med. (1990) [Pubmed]
  4. An ancient balanced polymorphism in a regulatory region of human major histocompatibility complex is retained in Chinese minorities but lost worldwide. Liu, X., Fu, Y., Liu, Z., Lin, B., Xie, Y., Liu, Y., Xu, Y., Lin, J., Fan, X., Dong, M., Zeng, K., Wu, C.I., Xu, A. Am. J. Hum. Genet. (2006) [Pubmed]
  5. Delineation of a previously unrecognized cis-acting element required for HLA class II gene expression. Sugawara, M., Ponath, P.D., Shin, J., Yang, Z., Strominger, J.L. Proc. Natl. Acad. Sci. U.S.A. (1991) [Pubmed]
  6. HLA-DPA1 promoter haplotypes are differently distributed in southern Chinese ethnic groups. Liu, X., Xu, Y., Shen, Y., Zhang, H., Fu, Y., Liu, Z., Xu, A. Tissue Antigens (2005) [Pubmed]
  7. HLA-DP antigens and post-streptococcal acute glomerulonephritis. Mori, K., Sasazuki, T., Kimura, A., Ito, Y. Acta Paediatr. (1996) [Pubmed]
  8. Genetic polymorphism and linkage disequilibrium of the HLA-DP region in Basques from Navarre (Spain). Pérez-Miranda, A.M., Alfonso-Sánchez, M.A., Vidales, M.C., Calderón, R., Peña, J.A. Tissue Antigens (2004) [Pubmed]
  9. The nucleotide sequence of two new DP alleles, DPA1*02015 and DPB1*8401, identified in a Chinese subject. McTernan, C.L., Mijovic, C.H., Cockram, C.S., Barnett, A.H. Tissue Antigens (2000) [Pubmed]
  10. Sequencing and population analysis of four novel HLA-DPA1 alleles. Harada, H., Kimura, A., Dong, R.P., Xu, X.P., Bhatia, K., Sasazuki, T. Hum. Immunol. (1992) [Pubmed]
  11. Exon 2, 3, and 4 polymorphism of HLA-DPA1. Rozemuller, E.H., Versluis, L.F., Bouwens, A.G., Tilanus, M.G. Immunogenetics (1995) [Pubmed]
  12. Roles of HLA-B, HLA-C and HLA-DPA1 incompatibilities in the outcome of unrelated stem-cell transplantation. Schaffer, M., Aldener-Cannavá, A., Remberger, M., Ringdén, O., Olerup, O. Tissue Antigens (2003) [Pubmed]
  13. Matching for HLA DPA1 and DPB1 alleles in unrelated bone marrow transplantation. Varney, M.D., Lester, S., McCluskey, J., Gao, X., Tait, B.D. Hum. Immunol. (1999) [Pubmed]
  14. Biochemical analysis of HLA-DP gene products by isoelectric focusing and comparison with cellular and molecular genetic typing results. Rebmann, V., Kubens, B.S., Ferencik, S., Grosse-Wilde, H. Exp. Clin. Immunogenet. (1995) [Pubmed]
  15. Regional variation in Langerhans cell distribution and density in normal human oral mucosa determined using monoclonal antibodies against CD1, HLADR, HLADQ and HLADP. Cruchley, A.T., Williams, D.M., Farthing, P.M., Lesch, C.A., Squier, C.A. J. Oral Pathol. Med. (1989) [Pubmed]
  16. Differential evolutionary MHC class II strategies in humans and rhesus macaques: relevance for biomedical studies. Doxiadis, G.G., Otting, N., de Groot, N.G., Bontrop, R.E. Immunol. Rev. (2001) [Pubmed]
  17. HLA-DP distribution in Shanghai Chinese--a study by polymerase chain reaction--restriction fragment length polymorphism. Wang, F.Q., al-Daccak, R., Ju, L.Y., Lethielleux, P., Charron, D., Loiseau, P., Colombani, J. Hum. Immunol. (1992) [Pubmed]
  18. Gene polymorphism of HLA-DPB1 and DPA1 loci in caucasoid population: frequencies and DPB1-DPA1 associations. al-Daccak, R., Wang, F.Q., Theophille, D., Lethielleux, P., Colombani, J., Loiseau, P. Hum. Immunol. (1991) [Pubmed]
  19. HLA-DPA1 typing by PCR amplification with sequence-specific primers (PCR-SSP) and distribution of DPA1 alleles in Caucasian, African and Oriental populations. Aldener-Cannavá, A., Olerup, O. Tissue Antigens (1996) [Pubmed]
 
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