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Gene Review

PCTP  -  phosphatidylcholine transfer protein

Bos taurus

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Disease relevance of PCTP


High impact information on PCTP


Biological context of PCTP

  • Towards the end of embryonic development, just before term, high levels of PC-TP RNA were found in the liver [7].
  • The predicted amino acid sequence was 90% similar (81% identical) to the corresponding sequence of bovine liver PC-TP, demonstrating that PC-TP is conserved among mammalian species [7].
  • PC-TP RNA was present in embryos at all stages of development as early as the embryonic stem cell, suggesting a role for PC-TP in cell growth and differentiation [7].
  • Given the proposed function of PC-TP in lipid metabolism, we have tested a number of compounds (phorbol ester, bombesin, A23187, thrombin, dibutyryl cyclic AMP, oleate, clofibrate, platelet-derived growth factor, epidermal growth factor, and hydrogen peroxide) for their ability to affect intracellular PC-TP distribution [6].
  • The data are discussed in terms of the structural organization of the sn-1 and sn-2 acyl binding sites of PC-TP and PI-TP.(ABSTRACT TRUNCATED AT 250 WORDS)[8]

Anatomical context of PCTP


Associations of PCTP with chemical compounds


Physical interactions of PCTP


Other interactions of PCTP


Analytical, diagnostic and therapeutic context of PCTP

  • By Southern blot analysis, evidence was obtained for the presence of a single bovine PC-TP-encoding gene [7].


  1. The binding of phosphatidylcholine to the phosphatidylcholine transfer protein: affinity and role in folding. de Brouwer, A.P., Bouma, B., van Tiel, C.M., Heerma, W., Brouwers, J.F., Bevers, L.E., Westerman, J., Roelofsen, B., Wirtz, K.W. Chem. Phys. Lipids (2001) [Pubmed]
  2. Phospholipid transfer activities in Morris hepatomas and the specific contribution of the phosphatidylcholine exchange protein. Poorthuis, B.J., van der Krift, T.P., Teerlink, T., Akeroyd, R., Hostetler, K.Y., Wirtz, K.W. Biochim. Biophys. Acta (1980) [Pubmed]
  3. The molecular species composition of phosphatidylcholine affects cellular properties in normal and sickle erythrocytes. Kuypers, F.A., Chiu, D., Mohandas, N., Roelofsen, B., Op den Kamp, J.A., Lubin, B. Blood (1987) [Pubmed]
  4. The lipid transfer activity of phosphatidylinositol transfer protein is sufficient to account for enhanced phospholipase C activity in turkey erythrocyte ghosts. Currie, R.A., MacLeod, B.M., Downes, C.P. Curr. Biol. (1997) [Pubmed]
  5. Stimulation of cholinephosphotransferase activity by phosphatidylcholine transfer protein. Regulation of membrane phospholipid synthesis by a cytosolic protein. Khan, Z.U., Helmkamp, G.M. J. Biol. Chem. (1990) [Pubmed]
  6. Clofibrate-induced relocation of phosphatidylcholine transfer protein to mitochondria in endothelial cells. de Brouwer, A.P., Westerman, J., Kleinnijenhuis, A., Bevers, L.E., Roelofsen, B., Wirtz, K.W. Exp. Cell Res. (2002) [Pubmed]
  7. cDNA cloning and tissue-specific expression of the phosphatidylcholine transfer protein gene. Geijtenbeek, T.B., Smith, A.J., Borst, P., Wirtz, K.W. Biochem. J. (1996) [Pubmed]
  8. Affinity of phosphatidylcholine molecular species for the bovine phosphatidylcholine and phosphatidylinositol transfer proteins. Properties of the sn-1 and sn-2 acyl binding sites. Kasurinen, J., van Paridon, P.A., Wirtz, K.W., Somerharju, P. Biochemistry (1990) [Pubmed]
  9. The complete primary structure of the phosphatidylcholine-transfer protein from bovine liver. Isolation and characterization of the cyanogen bromide peptides. Akeroyd, R., Moonen, P., Westerman, J., Puyk, W.C., Wirtz, K.W. Eur. J. Biochem. (1981) [Pubmed]
  10. Determination of the acyl chain specificity of the bovine liver phosphatidylcholine transfer protein. Application of pyrene-labeled phosphatidylcholine species. Somerharju, P.J., van Loon, D., Wirtz, K.W. Biochemistry (1987) [Pubmed]
  11. Identification of two classes of lipid molecule binding sites on the microsomal triglyceride transfer protein. Atzel, A., Wetterau, J.R. Biochemistry (1994) [Pubmed]
  12. Identification of an essential lysine residue in the phosphatidylcholine-transfer protein from bovine liver by modification with phenylisothiocyanate. van Loon, D., Westerman, J., Akeroyd, R., Wirtz, K.W. Eur. J. Biochem. (1986) [Pubmed]
  13. Submicellar bile salts stimulate phosphatidylcholine transfer activity of sterol carrier protein 2. Leonard, A.N., Cohen, D.E. J. Lipid Res. (1998) [Pubmed]
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