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STAR  -  steroidogenic acute regulatory protein

Bos taurus

 
 
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Disease relevance of STAR

 

High impact information on STAR

 

Biological context of STAR

  • The bovine StAR gene is transcribed as 3kb and 1.8kb transcripts, which differ in their sites of 3' polyadenylation [4].
  • Within the protein coding region of the bovine StAR gene, there is a marked 124 base homology to the 5' non-coding region of another luteal transcript, TIMP-1, suggesting a possible common regulatory function for this sequence [4].
  • These results demonstrate that Ca2+ exerts a transcriptional control on StAR protein expression and that ANP appears to elicit its inhibitory effect on aldosterone biosynthesis by acting as a negative physiological regulator of StAR gene expression [5].
  • A potent MEK inhibitor PD98059 eliminated ERK phosphorylation and augmented progesterone production concomitantly with the elevation of intracellular steroidogenic acute regulatory protein mRNA in LH/forskolin-stimulated theca cells [6].
  • In both cell systems, detectable upregulation of StAR gene transcription occurred within 1-2 h, reaching maxima at 4 h (theca cells) or 6 h (adrenocortical cells). mRNA levels returned rapidly to baseline, by 12 h or 24 h, respectively [7].
 

Anatomical context of STAR

 

Associations of STAR with chemical compounds

 

Physical interactions of STAR

 

Regulatory relationships of STAR

 

Other interactions of STAR

 

Analytical, diagnostic and therapeutic context of STAR

References

  1. The mechanism of action of steroidogenic acute regulatory protein (StAR). StAR acts on the outside of mitochondria to stimulate steroidogenesis. Arakane, F., Kallen, C.B., Watari, H., Foster, J.A., Sepuri, N.B., Pain, D., Stayrook, S.E., Lewis, M., Gerton, G.L., Strauss, J.F. J. Biol. Chem. (1998) [Pubmed]
  2. Repression of DAX-1 and induction of SF-1 expression. Two mechanisms contributing to the activation of aldosterone biosynthesis in adrenal glomerulosa cells. Osman, H., Murigande, C., Nadakal, A., Capponi, A.M. J. Biol. Chem. (2002) [Pubmed]
  3. Transforming growth factor beta1 decreases cholesterol supply to mitochondria via repression of steroidogenic acute regulatory protein expression. Brand, C., Cherradi, N., Defaye, G., Chinn, A., Chambaz, E.M., Feige, J.J., Bailly, S. J. Biol. Chem. (1998) [Pubmed]
  4. Molecular cloning and in vivo expression of the bovine steroidogenic acute regulatory protein. Hartung, S., Rust, W., Balvers, M., Ivell, R. Biochem. Biophys. Res. Commun. (1995) [Pubmed]
  5. Atrial natriuretic peptide inhibits calcium-induced steroidogenic acute regulatory protein gene transcription in adrenal glomerulosa cells. Cherradi, N., Brandenburger, Y., Rossier, M.F., Vallotton, M.B., Stocco, D.M., Capponi, A.M. Mol. Endocrinol. (1998) [Pubmed]
  6. Luteinizing hormone-induced extracellular-signal regulated kinase activation differently modulates progesterone and androstenedione production in bovine theca cells. Tajima, K., Yoshii, K., Fukuda, S., Orisaka, M., Miyamoto, K., Amsterdam, A., Kotsuji, F. Endocrinology (2005) [Pubmed]
  7. Acute regulation of the bovine gene for the steroidogenic acute regulatory protein in ovarian theca and adrenocortical cells. Ivell, R., Tillmann, G., Wang, H., Nicol, M., Stewart, P.M., Bartlick, B., Walther, N., Mason, J.I., Morley, S.D. J. Mol. Endocrinol. (2000) [Pubmed]
  8. Induction of Ad4BP/SF-1, steroidogenic acute regulatory protein, and cytochrome P450scc enzyme system expression in newly established human granulosa cell lines. Hosokawa, K., Dantes, A., Schere-Levy, C., Barash, A., Yoshida, Y., Kotsuji, F., Vlodavsky, I., Amsterdam, A. Endocrinology (1998) [Pubmed]
  9. Expression of steroidogenic acute regulatory protein messenger ribonucleic acid is limited to theca of healthy bovine follicles collected during recruitment, selection, and dominance of follicles of the first follicular wave. Bao, B., Calder, M.D., Xie, S., Smith, M.F., Salfen, B.E., Youngquist, R.S., Garverick, H.A. Biol. Reprod. (1998) [Pubmed]
  10. Chicken ovalbumin upstream promoter-transcription factor is a negative regulator of steroidogenesis in bovine adrenal glomerulosa cells. Buholzer, C.F., Arrighi, J.F., Abraham, S., Piguet, V., Capponi, A.M., Casal, A.J. Mol. Endocrinol. (2005) [Pubmed]
  11. Bone morphogenetic proteins (BMP) -4, -6, and -7 potently suppress basal and luteinizing hormone-induced androgen production by bovine theca interna cells in primary culture: could ovarian hyperandrogenic dysfunction be caused by a defect in thecal BMP signaling? Glister, C., Richards, S.L., Knight, P.G. Endocrinology (2005) [Pubmed]
  12. The binding of phosphatidylcholine to the phosphatidylcholine transfer protein: affinity and role in folding. de Brouwer, A.P., Bouma, B., van Tiel, C.M., Heerma, W., Brouwers, J.F., Bevers, L.E., Westerman, J., Roelofsen, B., Wirtz, K.W. Chem. Phys. Lipids (2001) [Pubmed]
  13. Oxytocin inhibits LH-stimulated production of androstenedione by bovine theca cells. Jo, M., Fortune, J.E. Mol. Cell. Endocrinol. (2002) [Pubmed]
  14. Differentiation-specific action of orphan nuclear receptor NR5A1 (SF-1): transcriptional regulation in luteinizing bovine theca cells. Walther, N., Jansen, M., Akbary, W., Ivell, R. Reprod. Biol. Endocrinol. (2006) [Pubmed]
  15. Ovarian follicular steroidogenic acute regulatory protein, low-density lipoprotein receptor, and cytochrome P450 side-chain cleavage messenger ribonucleic acids in cattle undergoing superovulation. Soumano, K., Price, C.A. Biol. Reprod. (1997) [Pubmed]
  16. Expression of 17beta- and 3beta-hydroxysteroid dehydrogenases and steroidogenic acute regulatory protein in non-luteinizing bovine granulosa cells in vitro. Sahmi, M., Nicola, E.S., Silva, J.M., Price, C.A. Mol. Cell. Endocrinol. (2004) [Pubmed]
 
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