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Gene Review

Pctp  -  phosphatidylcholine transfer protein

Rattus norvegicus

Synonyms: PC-TP, Phosphatidylcholine transfer protein, START domain-containing protein 2, StAR-related lipid transfer protein 2, StARD2, ...
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Disease relevance of Pctp

  • Transient transfection of a series of 5'-deleted Pctp-promoter-firefly luciferase constructs into Reuber H35 rat hepatoma cells, which express Pctp mRNA, and Gunn rat fibroblasts, which do not, suggest that cis-acting elements in a 637bp promoter region contribute to enhanced expression of PC-TP in liver [1].
  • These results demonstrate the utility of baculovirus for expressing recombinant phosphatidylcholine transfer protein and should facilitate studies designed to elucidate the structural biology and physiological functions of this uniquely specific phospholipid transfer protein [2].

High impact information on Pctp


Biological context of Pctp


Anatomical context of Pctp


Associations of Pctp with chemical compounds


Analytical, diagnostic and therapeutic context of Pctp


  1. Cloning and gene structure of rat phosphatidylcholine transfer protein, Pctp. Wu, M.K., Boylan, M.O., Cohen, D.E. Gene (1999) [Pubmed]
  2. Baculovirus-mediated expression of recombinant rat phosphatidylcholine transfer protein. Feng, L., Cohen, D.E. J. Lipid Res. (1998) [Pubmed]
  3. Regulation of casein kinase-2 (CK2) activity by inositol phosphates. Solyakov, L., Cain, K., Tracey, B.M., Jukes, R., Riley, A.M., Potter, B.V., Tobin, A.B. J. Biol. Chem. (2004) [Pubmed]
  4. Transmembrane movement of phosphatidylcholine in mitochondrial outer membrane vesicles. Dolis, D., de Kroon, A.I., de Kruijff, B. J. Biol. Chem. (1996) [Pubmed]
  5. Intracellular phospholipid movement and the role of phospholipid transfer proteins in animal cells. Yaffe, M.P., Kennedy, E.P. Biochemistry (1983) [Pubmed]
  6. Analyzing the structures, functions and evolution of two abundant gastrointestinal fatty acid binding proteins with recombinant DNA and computational techniques. Gordon, J.I., Lowe, J.B. Chem. Phys. Lipids (1985) [Pubmed]
  7. Tissue distribution and subcellular localization of phosphatidylcholine transfer protein in rats as determined by radioimmunoassay. Teerlink, T., Van der Krift, T.P., Post, M., Wirtz, K.W. Biochim. Biophys. Acta (1982) [Pubmed]
  8. Microsomal membranes contain phosphatidylcholine that equilibrates across the bilayer, and phosphatidylcholine that does not. Hutson, J.L., Higgins, J.A., Wirtz, K.W. FEBS Lett. (1985) [Pubmed]
  9. Phosphatidylcholine participates in the interaction between macrophages and lymphocytes. Nishiyama-Naruke, A., Curi, R. Am. J. Physiol., Cell Physiol. (2000) [Pubmed]
  10. Vitamin D metabolites stimulate phosphatidylcholine transfer to renal brush-border membranes. Kurnik, B.R., Huskey, M., Hagerty, D., Hruska, K.A. Biochim. Biophys. Acta (1986) [Pubmed]
  11. The phosphatidylcholine-transfer protein catalyzed import of phosphatidylcholine into isolated rat liver mitochondria. Nicolay, K., Hovius, R., Bron, R., Wirtz, K., de Kruijff, B. Biochim. Biophys. Acta (1990) [Pubmed]
  12. The synthesis of sphingomyelin in the Morris hepatomas 7777 and 5123D is restricted to the plasma membrane. van den Hill, A., van Heusden, G.P., Wirtz, K.W. Biochim. Biophys. Acta (1985) [Pubmed]
  13. Effect of chlorpromazine on intracellular transport of phospholipids. Ide, H., Nakazawa, Y. Chem. Biol. Interact. (1981) [Pubmed]
  14. Measurement of phosphatidylcholine transfer protein in rat liver and hepatomas by radioimmunoassay. Teerlink, T., Poorthuis, B.J., Van der Krift, T.P., Wirtz, K.W. Biochim. Biophys. Acta (1981) [Pubmed]
  15. Effect of N-ethylmaleimide on rat liver phosphatidylcholine-specific and non-specific transfer protein activities: its dependence on donor liposome composition. Altamura, N., Landriscina, C. Int. J. Biochem. (1986) [Pubmed]
  16. Acyl-chain specificity and membrane fluidity. Factors which influence the activity of a purified phospholipid-transfer protein from lung. Read, R.J., Funkhouser, J.D. Biochim. Biophys. Acta (1984) [Pubmed]
  17. Phosphatidylcholine transfer protein from rat liver: purification and radioimmunoassay. Teerlink, T., Poorthuis, B.J., Wirtz, K.W. Meth. Enzymol. (1983) [Pubmed]
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