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Gene Review

PCTP  -  phosphatidylcholine transfer protein

Homo sapiens

Synonyms: PC-TP, Phosphatidylcholine transfer protein, STARD2, START domain-containing protein 2, StAR-related lipid transfer protein 2, ...
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Disease relevance of PCTP

  • Optimization of codon usage for bacterial protein translation increased expression of PC-TP from trace levels to >10% of the E. coli cytosolic protein mass [1].

High impact information on PCTP


Chemical compound and disease context of PCTP


Biological context of PCTP


Anatomical context of PCTP


Associations of PCTP with chemical compounds


Other interactions of PCTP


Analytical, diagnostic and therapeutic context of PCTP


  1. High-level expression and mutagenesis of recombinant human phosphatidylcholine transfer protein using a synthetic gene: evidence for a C-terminal membrane binding domain. Feng, L., Chan, W.W., Roderick, S.L., Cohen, D.E. Biochemistry (2000) [Pubmed]
  2. Structure of human phosphatidylcholine transfer protein in complex with its ligand. Roderick, S.L., Chan, W.W., Agate, D.S., Olsen, L.R., Vetting, M.W., Rajashankar, K.R., Cohen, D.E. Nat. Struct. Biol. (2002) [Pubmed]
  3. Etiologic significance of defects in cholesterol, phospholipid, and bile acid metabolism in the liver of patients with intrahepatic calculi. Shoda, J., Oda, K., Suzuki, H., Sugiyama, Y., Ito, K., Cohen, D.E., Feng, L., Kamiya, J., Nimura, Y., Miyazaki, H., Kano, M., Matsuzaki, Y., Tanaka, N. Hepatology (2001) [Pubmed]
  4. Regulation of eukaryotic phospholipid metabolism. Kent, C., Carman, G.M., Spence, M.W., Dowhan, W. FASEB J. (1991) [Pubmed]
  5. Phosphatidylcholine transfer protein promotes apolipoprotein A-I-mediated lipid efflux in Chinese hamster ovary cells. Baez, J.M., Barbour, S.E., Cohen, D.E. J. Biol. Chem. (2002) [Pubmed]
  6. GTT1/StarD7, a novel phosphatidylcholine transfer protein-like highly expressed in gestational trophoblastic tumour: cloning and characterization. Durand, S., Angeletti, S., Genti-Raimondi, S. Placenta (2004) [Pubmed]
  7. Effects of hydrophobicity on turnover of plasma high density lipoproteins labeled with phosphatidylcholine ethers in the rat. Pownall, H.J., Hickson-Bick, D., Massey, J.B. J. Lipid Res. (1991) [Pubmed]
  8. Phospholipid transfer activities in toad oocytes and developing embryos. Rusiñol, A., Salomón, R.A., Bloj, B. J. Lipid Res. (1987) [Pubmed]
  9. Kinetics of phospholipid transfer between liposomes (neutral or negatively charged) and high-density lipoproteins: a spin-label study of early events. Bienvenüe, A., Vidal, M., Sainte-Marie, J., Philippot, J. Biochim. Biophys. Acta (1985) [Pubmed]
  10. Purification and characterization of a phosphatidylinositol transfer protein from human platelets. George, P.Y., Helmkamp, G.M. Biochim. Biophys. Acta (1985) [Pubmed]
  11. Human phosphatidylcholine transfer protein: purification, crystallization and preliminary X-ray diffraction data. Chan, W.W., Roderick, S.L., Cohen, D.E. Biochim. Biophys. Acta (2002) [Pubmed]
  12. Phospholipid transfer protein mediates transfer of not only phosphatidylcholine but also cholesterol from phosphatidylcholine-cholesterol vesicles to high density lipoproteins. Nishida, H.I., Nishida, T. J. Biol. Chem. (1997) [Pubmed]
  13. Inter-relationship of lipids transferred by the lipid-transfer protein isolated from human lipoprotein-deficient plasma. Morton, R.E., Zilversmit, D.B. J. Biol. Chem. (1983) [Pubmed]
  14. High density lipoprotein conversion mediated by human plasma phospholipid transfer protein. Tu, A.Y., Nishida, H.I., Nishida, T. J. Biol. Chem. (1993) [Pubmed]
  15. Human alpha-tocopherol transfer protein: cDNA cloning, expression and chromosomal localization. Arita, M., Sato, Y., Miyata, A., Tanabe, T., Takahashi, E., Kayden, H.J., Arai, H., Inoue, K. Biochem. J. (1995) [Pubmed]
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