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Gene Review

HINT1  -  histidine triad nucleotide binding protein 1

Bos taurus

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High impact information on HINT1

  • Pretreatment of endothelial cells with the protein kinase C inhibitor, calphostin C, or with 8-bromoadenosine 3',5'-cyclic monophosphate prevented the decreased impedance, suggesting that the endothelial cell change is modulated by activation of second-messenger pathways [1].
  • In agreement with our recent report, PGE2 and TPA induced a sustained increase in intracellular pH that was abolished by the protein kinase C inhibitor staurosporine but not by the calmodulin inhibitor W-7 [2].
  • The palmitate-induced increase in mitogen-activated protein kinase activity was restored to control concentrations by GF109203X (5 x 10(-7) mol/l), a specific protein kinase C inhibitor, suggesting a protein kinase C-dependent activation of mitogen-activated protein kinase [3].
  • These LPL effects were abrogated by the specific protein kinase C inhibitor calphostin C (1 micromol/L) [4].
  • Treatment of the explants with graded levels of the protein kinase C inhibitor chelerythrine or bisindolylmaleimide I, followed by 1 h compressive loading, did not significantly alter the load-induced elevation of aggrecan mRNA levels [5].

Biological context of HINT1


Anatomical context of HINT1

  • Inhibition of nicotinic responses of bovine adrenal chromaffin cells by the protein kinase C inhibitor, Ro 31-8220 [9].
  • Quercitin, a protein kinase C inhibitor in other systems, inhibited the thyroid enzyme in a dose-related manner [11].
  • The effect of TPA on the zona glomerulosa ANF-R1 receptors was abolished by calphostin C, a specific protein kinase C inhibitor [12].
  • The 110 kDa polypeptide and its fragments were phosphorylated by a nuclear envelope kinase and this phosphorylation was inhibited by a monoclonal antibody against protein kinase C and by a specific protein kinase C inhibitor obtained from bovine brain [13].
  • The monocyte migration induced by the elastin-derived peptide was inhibited by cGMP dependent protein kinase (PKG) inhibitor, but not by cAMP dependent protein kinase inhibitor and protein kinase C inhibitor [14].

Associations of HINT1 with chemical compounds

  • The agonist stimulation of phospholipase D was dependent on protein kinase C, as judged by its sensitivity to the relatively selective protein kinase C inhibitor Ro 31-8220 [15].
  • Staurosporine, a protein kinase C inhibitor, was found to abolish Ca2(+)-dependent arachidonic acid release completely, but had only a slight inhibitory effect on Ca2(+)-dependent secretion [16].
  • In addition, we found that the protein kinase C inhibitor Ro 31-7549 blocked Fos-lacZ expression induced by TPA but had little or no effect on that elicited by high calcium levels [17].
  • Pretreatment of BAG cells with staurosporine (a protein kinase C inhibitor) and R24571 (a calmodulin inhibitor) did not modify Ang II-induced desensitization of AT1 receptor.(ABSTRACT TRUNCATED AT 400 WORDS)[18]
  • Staurosporine, a protein kinase C inhibitor, prevented the activation of PK46 and PK42 by DMPP and PDBu but did not block the activation of these kinases by IGF-I [19].

Other interactions of HINT1


  1. Electrical method for detection of endothelial cell shape change in real time: assessment of endothelial barrier function. Tiruppathi, C., Malik, A.B., Del Vecchio, P.J., Keese, C.R., Giaever, I. Proc. Natl. Acad. Sci. U.S.A. (1992) [Pubmed]
  2. Involvement of protein kinase C in prostaglandin E2-induced catecholamine release from cultured bovine adrenal chromaffin cells. Negishi, M., Ito, S., Hayaishi, O. J. Biol. Chem. (1990) [Pubmed]
  3. Saturated non-esterified fatty acids stimulate de novo diacylglycerol synthesis and protein kinase c activity in cultured aortic smooth muscle cells. Yu, H.Y., Inoguchi, T., Kakimoto, M., Nakashima, N., Imamura, M., Hashimoto, T., Umeda, F., Nawata, H. Diabetologia (2001) [Pubmed]
  4. Differentiation of human monocytes to monocyte-derived macrophages is associated with increased lipoprotein lipase-induced tumor necrosis factor-alpha expression and production: a process involving cell surface proteoglycans and protein kinase C. Mamputu, J.C., Renier, G. Arterioscler. Thromb. Vasc. Biol. (1999) [Pubmed]
  5. myo-Inositol 1,4,5-trisphosphate and Ca(2+)/calmodulin-dependent factors mediate transduction of compression-induced signals in bovine articular chondrocytes. Valhmu, W.B., Raia, F.J. Biochem. J. (2002) [Pubmed]
  6. Characterization of a novel zinc binding site of protein kinase C inhibitor-1. Mozier, N.M., Walsh, M.P., Pearson, J.D. FEBS Lett. (1991) [Pubmed]
  7. Purification and characterization of protein kinase C from rabbit iris smooth muscle. Myosin light-chain phosphorylation in vitro and in intact muscle. Howe, P.H., Abdel-Latif, A.A. Biochem. J. (1988) [Pubmed]
  8. Phorbol esters and d-tubocurarine up-regulate alpha-bungarotoxin sites in chromaffin cells in culture via distinct mechanisms. Geertsen, S., Afar, R., Trifaró, J.M., Quik, M. Neuroscience (1990) [Pubmed]
  9. Inhibition of nicotinic responses of bovine adrenal chromaffin cells by the protein kinase C inhibitor, Ro 31-8220. Marley, P.D., Thomson, K.A. Br. J. Pharmacol. (1996) [Pubmed]
  10. Prevention of the TPA-mediated down-regulation of protein kinase C. Grove, D.S., Mastro, A.M. Biochem. Biophys. Res. Commun. (1988) [Pubmed]
  11. Diacylglycerol-activated, calcium/phospholipid-dependent protein kinase (protein kinase C) activity in bovine thyroid. Friedman, Y., Poleck, T., Henricks, L., Burke, G. Biochem. Biophys. Res. Commun. (1985) [Pubmed]
  12. Phosphorylation of atrial natriuretic factor R1 receptor by serine/threonine protein kinases: evidences for receptor regulation. Larose, L., Rondeau, J.J., Ong, H., De Léan, A. Mol. Cell. Biochem. (1992) [Pubmed]
  13. Immunological evidence for the localization of a 110 kDa poly(A) binding protein from rat liver in nuclear envelopes and its phosphorylation by protein kinase C. Schäfer, P., Aitken, S.J., Bachmann, M., Agutter, P.S., Müller, W.E., Prochnow, D. Cell. Mol. Biol. (Noisy-le-grand) (1993) [Pubmed]
  14. Elastin-derived peptide induces monocyte chemotaxis by increasing intracellular cyclic GMP level and activating cyclic GMP dependent protein kinase. Uemura, Y., Okamoto, K. Biochem. Mol. Biol. Int. (1997) [Pubmed]
  15. Stimulation of phosphatidate synthesis in endothelial cells in response to P2-receptor activation. Evidence for phospholipase C and phospholipase D involvement, phosphatidate and diacylglycerol interconversion and the role of protein kinase C. Purkiss, J.R., Boarder, M.R. Biochem. J. (1992) [Pubmed]
  16. Relationship between arachidonic acid release and Ca2(+)-dependent exocytosis in digitonin-permeabilized bovine adrenal chromaffin cells. Morgan, A., Burgoyne, R.D. Biochem. J. (1990) [Pubmed]
  17. Regulation of fos-lacZ fusion gene expression in primary mouse epidermal keratinocytes isolated from transgenic mice. Bollag, W.B., Xiong, Y., Ducote, J., Harmon, C.S. Biochem. J. (1994) [Pubmed]
  18. Short-term desensitization of the angiotensin II receptor of bovine adrenal glomerulosa cells corresponds to a shift from a high to a low affinity state. Boulay, G., Chrétien, L., Richard, D.E., Guillemette, G. Endocrinology (1994) [Pubmed]
  19. Nicotinic agonists, phorbol esters, and growth factors activate two extracellular signal-regulated kinases, ERK1 and ERK2, in bovine chromaffin cells. Pavlović-Surjancev, B., Cahill, A.L., Perlman, R.L. J. Neurochem. (1992) [Pubmed]
  20. Activation of tyrosine hydroxylase by histamine in bovine chromaffin cells. Marley, P.D., Robotis, R. J. Auton. Nerv. Syst. (1998) [Pubmed]
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