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Chemical Compound Review

Dimethylphenylpiperazinium     1,1-dimethyl-4-phenyl- 2,3,5,6...

Synonyms: Lopac-D-5891, CHEMBL134752, SureCN3453554, CHEBI:320207, CCG-204493, ...
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Disease relevance of Dimethylphenylpiperazinium

  • K+-evoked release was unaffected by hypoxia (PO2 approximately 30-38 mm Hg), but release evoked by DMPP was significantly increased [1].
  • Another result of the research was the identification of DMPP analogues, such as 3a (K(i) = 90 nM) and 14b (K(i) = 180 nM), that maintain affinity for the central nicotinic receptor when the ammonium function is changed into an aminic one and are therefore possible leads for drug development in neurodegenerative diseases [2].
  • The uptake of Ca++ by ganglion cells is not an adequate stimulus for cGMP accumulation because the nicotinic receptor agonist dimethylphenylpiperazinium increases 45Ca-uptake but has no effect on cGMP formation in ganglia [3].
  • 4. The four omega-conotoxins as well as atropine produced similar partial inhibition (53-62%) of the contractures evoked by dimethylphenylpiperazinium, while tetrodotoxin inhibited the contracture completely [4].
  • When tachycardia was induced by chemical stimulation of nicotinic (DMPP), muscarinic (McN-A-343-11) or histamine receptors in the stellate ganglia, opiates were still active in reducing the effect of these chemicals [5].

High impact information on Dimethylphenylpiperazinium


Chemical compound and disease context of Dimethylphenylpiperazinium


Biological context of Dimethylphenylpiperazinium


Anatomical context of Dimethylphenylpiperazinium


Associations of Dimethylphenylpiperazinium with other chemical compounds


Gene context of Dimethylphenylpiperazinium


Analytical, diagnostic and therapeutic context of Dimethylphenylpiperazinium


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  2. Structure-affinity relationships of a unique nicotinic ligand: N(1)-dimethyl-N(4)-phenylpiperazinium iodide (DMPP). Romanelli, M.N., Manetti, D., Scapecchi, S., Borea, P.A., Dei, S., Bartolini, A., Ghelardini, C., Gualtieri, F., Guandalini, L., Varani, K. J. Med. Chem. (2001) [Pubmed]
  3. Cyclic guanosine 3':5'-monophosphate accumulation and 45Ca-uptake by rat superior cervical ganglia during preganglionic stimulation. Volle, R.L., Quenzer, L.F., Patterson, B.A., Alkadhi, K.A., Henderson, E.G. J. Pharmacol. Exp. Ther. (1981) [Pubmed]
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  16. Evidence that the Rab3a-binding protein, rabphilin3a, enhances regulated secretion. Studies in adrenal chromaffin cells. Chung, S.H., Takai, Y., Holz, R.W. J. Biol. Chem. (1995) [Pubmed]
  17. Differential inhibition of secretagogue-stimulated sodium uptake in adrenal chromaffin cells by activation of D4 and D5 dopamine receptors. Dahmer, M.K., Senogles, S.E. J. Neurochem. (1996) [Pubmed]
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  20. Assembly of human neuronal nicotinic receptor alpha5 subunits with alpha3, beta2, and beta4 subunits. Wang, F., Gerzanich, V., Wells, G.B., Anand, R., Peng, X., Keyser, K., Lindstrom, J. J. Biol. Chem. (1996) [Pubmed]
  21. Neuromuscular function of the human lower oesophageal sphincter in reflux disease and Barrett's oesophagus. Smid, S.D., Blackshaw, L.A. Gut (2000) [Pubmed]
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  23. Prejunctional effects of the nicotinic ACh receptor agonist dimethylphenylpiperazinium at the rat neuromuscular junction. Singh, S., Prior, C. J. Physiol. (Lond.) (1998) [Pubmed]
  24. Evidence for the release of newly acquired ascorbate and alpha-aminoisobutyric acid from the cytosol of adrenomedullary chromaffin cells through specific transporter mechanisms. Knoth, J., Viveros, O.H., Diliberto, E.J. J. Biol. Chem. (1987) [Pubmed]
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  26. Possible role of nitric oxide in catecholamine secretion by chromaffin cells in the presence and absence of cultured endothelial cells. Torres, M., Ceballos, G., Rubio, R. J. Neurochem. (1994) [Pubmed]
  27. Effects on serotonin of (-)nicotine and dimethylphenylpiperazinium in the dorsal raphe and nucleus accumbens of freely behaving rats. Ma, Z., Strecker, R.E., McKenna, J.T., Thakkar, M.M., McCarley, R.W., Tao, R. Neuroscience (2005) [Pubmed]
  28. Identical patterns of somatostatin secretion from isolated antrum and fundus of rat stomach. Schubert, M.L., Saffouri, B., Makhlouf, G.M. Am. J. Physiol. (1988) [Pubmed]
  29. Dimethyphenylpiperazinium, a nicotinic receptor agonist, downregulates inflammation in monocytes/macrophages through PI3K and PLC chronic activation. Blanchet, M.R., Israël-Assayag, E., Daleau, P., Beaulieu, M.J., Cormier, Y. Am. J. Physiol. Lung Cell Mol. Physiol. (2006) [Pubmed]
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  33. Nerve terminal nicotinic cholinergic receptors on excitatory motoneurons in the myenteric plexus of guinea pig intestine. Galligan, J.J. J. Pharmacol. Exp. Ther. (1999) [Pubmed]
  34. Muscarinic modulation of acetylcholine release evoked by dimethylphenylpiperazinium and high potassium from guinea-pig myenteric plexus. Dzieniszewski, P., Kilbinger, H. Eur. J. Pharmacol. (1978) [Pubmed]
  35. Sympathetic regulation of cutaneous circulation in the rat. Willette, R.N., Hieble, J.P., Sauermelch, C.F. J. Auton. Nerv. Syst. (1991) [Pubmed]
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