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Chemical Compound Review

SHAM     N,2-dihydroxybenzamide

Synonyms: S607_ALDRICH, CHEMBL309339, NSC-5088, ACMC-209r2n, CHEBI:45615, ...
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Disease relevance of NSC 193440


High impact information on NSC 193440

  • Trypanosoma brucei possesses a non-cytochrome, salicylhydroxamic acid (SHAM)-sensitive ubiquinol:oxygen oxidoreductase known as trypanosome alternative oxidase (TAO) [6].
  • While oxygen consumption was cyanide insensitive, inhibition occurred following treatment with complex III inhibitors and the alternative oxidase inhibitor, salicylhydroxamic acid (SHAM) [7].
  • No differences in peroxidatic activity or inhibition by salicylhydroxamic acid were observed among any of the MPO isoforms or resolved protomers, but the latter were considerably more heat labile than dimeric forms of the enzyme and a monomeric form isolated from HL-60 cells [8].
  • Coupling of the PSMA-specific monoclonal antibody, J591, to the vector was facilitated via the high-affinity interaction between phenyl(di)boronic acid and salicylhydroxamic acid molecules [9].
  • The decrease in stable-isotope-labeled avenanthramides was suppressed by catalase, salicylhydroxamic acid, and sodium ascorbate, suggesting the involvement of peroxidase in the metabolism [10].

Biological context of NSC 193440


Anatomical context of NSC 193440


Associations of NSC 193440 with other chemical compounds


Gene context of NSC 193440


Analytical, diagnostic and therapeutic context of NSC 193440


  1. Cytoplasmic and nuclear mutations to chloramphenicol resistance in Aspergillus nidulans. Gunatilleke, I.A., Scazzocchio, C., Arst, H.N. Mol. Gen. Genet. (1975) [Pubmed]
  2. Pleomorphism and the problem of recrudescent parasitaemia following treatment with salicylhydroxamic acid (SHAM) in African trypanosomiasis. Evans, D.A., Brightman, C.A. Trans. R. Soc. Trop. Med. Hyg. (1980) [Pubmed]
  3. Quantitative effects of salycylhydroxamic acid and glycerol on Trypanosoma brucei glycolysis in vitro and in vivo. Brohn, F.H., Clarkson, A.B. Acta Trop. (1978) [Pubmed]
  4. Role of myeloperoxidase in the killing of Staphylococcus aureus by human neutrophils: studies with the myeloperoxidase inhibitor salicylhydroxamic acid. Humphreys, J.M., Davies, B., Hart, C.A., Edwards, S.W. J. Gen. Microbiol. (1989) [Pubmed]
  5. Salicylhydroxamic acid (SHAM) inhibits O(2) photoreduction which protects nitrogenase activity in the cyanobacterium Synechococcus sp. RF-1. Weng, J.H., Shieh, Y.J. Photosyn. Res. (2004) [Pubmed]
  6. Site-directed mutagenesis reveals the essentiality of the conserved residues in the putative diiron active site of the trypanosome alternative oxidase. Ajayi, W.U., Chaudhuri, M., Hill, G.C. J. Biol. Chem. (2002) [Pubmed]
  7. Characterization of a split respiratory pathway in the wheat "take-all" fungus, Gaeumannomyces graminis var. tritici. Joseph-Horne, T., Wood, P.M., Wood, C.K., Moore, A.L., Headrick, J., Hollomon, D. J. Biol. Chem. (1998) [Pubmed]
  8. Distinct chromatographic forms of human hemi-myeloperoxidase obtained by reductive cleavage of the dimeric enzyme. Evidence for subunit heterogeneity. Taylor, K.L., Guzman, G.S., Pohl, J., Kinkade, J.M. J. Biol. Chem. (1990) [Pubmed]
  9. Successful in vivo tumor targeting of prostate-specific membrane antigen with a highly efficient J591/PEI/DNA molecular conjugate. Moffatt, S., Papasakelariou, C., Wiehle, S., Cristiano, R. Gene Ther. (2006) [Pubmed]
  10. Metabolism of avenanthramide phytoalexins in oats. Okazaki, Y., Isobe, T., Iwata, Y., Matsukawa, T., Matsuda, F., Miyagawa, H., Ishihara, A., Nishioka, T., Iwamura, H. Plant J. (2004) [Pubmed]
  11. Hydrogen peroxide production in uncoupled mitochondria of the parasitic nematode worm Nippostrongylus brasiliensis. Paget, T.A., Fry, M., Lloyd, D. Biochem. J. (1987) [Pubmed]
  12. Alternative oxidase inhibitors potentiate the activity of atovaquone against Plasmodium falciparum. Murphy, A.D., Lang-Unnasch, N. Antimicrob. Agents Chemother. (1999) [Pubmed]
  13. Binding of salicylhydroxamic acid and several aromatic donor molecules to Arthromyces ramosus peroxidase, investigated by X-ray crystallography, optical difference spectroscopy, NMR relaxation, molecular dynamics, and kinetics. Tsukamoto, K., Itakura, H., Sato, K., Fukuyama, K., Miura, S., Takahashi, S., Ikezawa, H., Hosoya, T. Biochemistry (1999) [Pubmed]
  14. Binding of fluid-phase complement components C3 and C3b to human lymphocytes. Sim, E., Sim, R.B. Biochem. J. (1981) [Pubmed]
  15. The mitochondrial genome can be altered or lost without lethal effect in the petite-negative yeast Debaryomyces (Schwanniomyces) occidentalis. Fernet, C.S., Clark-Walker, G.D., Claisse, M.L. Curr. Genet. (2002) [Pubmed]
  16. Inhibition of myeloperoxidase by salicylhydroxamic acid. Davies, B., Edwards, S.W. Biochem. J. (1989) [Pubmed]
  17. Electron transport in the cni-1 mutant of Neurospora crassa. Edwards, D.L., Klein, J.L., Warden, J.T. Eur. J. Biochem. (1978) [Pubmed]
  18. Purification and characterization of salicylhydroxamic acid reductase from rat liver. Katsura, H., Kitamura, S., Tatsumi, K. Arch. Biochem. Biophys. (1993) [Pubmed]
  19. Salicylhydroxamic acid functionalized affinity membranes for specific immobilization of proteins and oligonucleotides. Springer, A.L., Gall, A.S., Hughes, K.A., Kaiser, R.J., Li, G., Lund, K.P. Journal of biomolecular techniques : JBT. (2003) [Pubmed]
  20. Oxygen consumption in Plasmodium berghei-infected murine red cells: a direct spectrophotometric assay in intact erythrocytes. Deslauriers, R., Moffatt, D.J., Smith, I.C. Biochim. Biophys. Acta (1986) [Pubmed]
  21. Salicylhydroxamic acid potentiates germination of 'Waldmann's Green' lettuce seed. Brooks, C.A., Yu, K.S., Mitchell, C.A. Plant Physiol. (1985) [Pubmed]
  22. p-Alkyloxybenzhydroxamic acids, effective inhibitors of the trypanosome glycerol-3-phosphate oxidase. Grady, R.W., Bienen, E.J., Clarkson, A.B. Mol. Biochem. Parasitol. (1986) [Pubmed]
  23. The alternate respiratory pathway of Candida albicans. Shepherd, M.G., Chin, C.M., Sullivan, P.A. Arch. Microbiol. (1978) [Pubmed]
  24. Alternative oxidase present in procyclic Trypanosoma brucei may act to lower the mitochondrial production of superoxide. Fang, J., Beattie, D.S. Arch. Biochem. Biophys. (2003) [Pubmed]
  25. Characterization of two non-homoeologous nuclear genes encoding mitochondrial alternative oxidase in common wheat. Takumi, S., Tomioka, M., Eto, K., Naydenov, N., Nakamura, C. Genes Genet. Syst. (2002) [Pubmed]
  26. A novel family of hydroxamate-based acylating inhibitors of cyclooxygenase. Dooley, C.M., Devocelle, M., McLoughlin, B., Nolan, K.B., Fitzgerald, D.J., Sharkey, C.T. Mol. Pharmacol. (2003) [Pubmed]
  27. Regulation of alternative oxidase activity in six wild monocotyledonous species. An in vivo study at the whole root level. Millenaar, F.F., Gonzàlez-Meler, M.A., Fiorani, F., Welschen, R., Ribas-Carbo, M., Siedow, J.N., Wagner, A.M., Lambers, H. Plant Physiol. (2001) [Pubmed]
  28. Relationship among lipoperoxides, jasmonates and indole-3-acetic acid formation in potato tuber after wounding. Reverberi, M., Fanelli, C., Zjalic, S., Briganti, S., Picardo, M., Ricelli, A., Fabbri, A.A. Free Radic. Res. (2005) [Pubmed]
  29. Participation of liver aldehyde oxidase in reductive metabolism of hydroxamic acids to amides. Sugihara, K., Tatsumi, K. Arch. Biochem. Biophys. (1986) [Pubmed]
  30. Determination of salicylhydroxamic acid, a trypanocidal agent, by reversed phase high-performance liquid chromatography. Barnicoat, A.J., van 't Hoff, W.G., Morrison, P.J., Bradbrook, I.D. J. Chromatogr. (1981) [Pubmed]
  31. The acidic constants of 2-hydroxybenzohydroxamic acid in NaClO4 solutions at 25 degrees C. Ciavatta, L., De Tommaso, G., Iuliano, M. Annali di chimica. (2004) [Pubmed]
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