Gene Review:
Trhde - thyrotropin-releasing hormone degrading...
Rattus norvegicus
Synonyms:
PAP-II, Pyroglutamyl-peptidase II, TRH-DE, TRH-degrading ectoenzyme, TRH-specific aminopeptidase, ...
- Identification of a second rat pancreatitis-associated protein. Messenger RNA cloning, gene structure, and expression during acute pancreatitis. Frigerio, J.M., Dusetti, N.J., Keim, V., Dagorn, J.C., Iovanna, J.L. Biochemistry (1993)
- Cloning of a cDNA encoding an ectoenzyme that degrades thyrotropin-releasing hormone. Schauder, B., Schomburg, L., Köhrle, J., Bauer, K. Proc. Natl. Acad. Sci. U.S.A. (1994)
- Homology modeling and site-directed mutagenesis of pyroglutamyl peptidase II. Insights into omega-versus aminopeptidase specificity in the M1 family. Chávez-Gutiérrez, L., Matta-Camacho, E., Osuna, J., Horjales, E., Joseph-Bravo, P., Maigret, B., Charli, J.L. J. Biol. Chem. (2006)
- A family of 16-kDa pancreatic secretory stress proteins form highly organized fibrillar structures upon tryptic activation. Graf, R., Schiesser, M., Scheele, G.A., Marquardt, K., Frick, T.W., Ammann, R.W., Bimmler, D. J. Biol. Chem. (2001)
- Regulation of the adenohypophyseal thyrotropin-releasing hormone-degrading ectoenzyme by estradiol. Schomburg, L., Bauer, K. Endocrinology (1997)
- Thyroid hormones rapidly and stringently regulate the messenger RNA levels of the thyrotropin-releasing hormone (TRH) receptor and the TRH-degrading ectoenzyme. Schomburg, L., Bauer, K. Endocrinology (1995)
- Analysis of the thyrotropin-releasing hormone-degrading ectoenzyme by site-directed mutagenesis of cysteine residues. Cys68 is involved in disulfide-linked dimerization. Papadopoulos, T., Heuer, H., Bauer, K. Eur. J. Biochem. (2000)
- Purification and characterization of the thyrotropin-releasing hormone (TRH)-degrading serum enzyme and its identification as a product of liver origin. Schmitmeier, S., Thole, H., Bader, A., Bauer, K. Eur. J. Biochem. (2002)
- Some events of thyrotropin-releasing hormone metabolism are regulated in lactating and cycling rats. Uribe, R.M., Joseph-Bravo, P., Pasten, J., Ponce, G., Méndez, M., Covarrubias, L., Charli, J.L. Neuroendocrinology (1991)
- Region-specific expression of thyrotrophin-releasing hormone-degrading ectoenzyme in the rat central nervous system and pituitary gland. Heuer, H., Ehrchen, J., Bauer, K., Schäfer, M.K. Eur. J. Neurosci. (1998)
- Regulation of thyrotropin releasing hormone degrading enzymes in rat brain and pituitary by L-3,5,3'-triiodothyronine. Suen, C.S., Wilk, S. J. Neurochem. (1989)
- Delineation of a particulate thyrotropin-releasing hormone-degrading enzyme in rat brain by the use of specific inhibitors of prolyl endopeptidase and pyroglutamyl peptide hydrolase. Friedman, T.C., Wilk, S. J. Neurochem. (1986)
- Pharmacologically distinct binding sites in rat brain for [3H]thyrotropin-releasing hormone (TRH) and [3H][3-methyl-histidine(2)]TRH. Kelly, J.A., Slator, G.R., O'Boyle, K.M. Biochem. Pharmacol. (2002)
- Pyroglutamyl peptidase II inhibition specifically increases recovery of TRH released from rat brain slices. Charli, J.L., Mendez, M., Vargas, M.A., Cisneros, M., Assai, M., Joseph-Bravo, P., Wilk, S. Neuropeptides (1989)
- Thyrotropin-releasing hormone downregulates pyroglutamyl peptidase II activity in adenohypophyseal cells. Vargas, M.A., Joseph-Bravo, P., Charli, J.L. Neuroendocrinology (1994)
- The elongated PAP II/Reg III mRNA is upregulated in rat pancreas during acute experimental pancreatitis. Honda, H., Nakamura, H., Otsuki, M. Pancreas (2002)
- Cloning, expression and chromosomal localization of the rat pancreatitis-associated protein III gene. Dusetti, N.J., Frigerio, J.M., Szpirer, C., Dagorn, J.C., Iovanna, J.L. Biochem. J. (1995)
- Mutational analysis of the thyrotropin-releasing hormone-degrading ectoenzyme. similarities and differences with other members of the M1 family of aminopeptidases and thermolysin. Papadopoulos, T., Kelly, J.A., Bauer, K. Biochemistry (2001)