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CTA_0078  -  esterase

Chlamydia trachomatis A/HAR-13

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Disease relevance of CTA_0078

  • Among 435 boys who agreed to undergo urethral culture, the esterase was positive in 66 (15%), Chlamydia trachomatis was isolated from 39 (9%), and Neisseria gonorrhoeae was isolated from 14 (3%) [1].
  • Using the esterase test to screen asymptomatic males for urethritis, we identified 38 culture-verified infections that otherwise would have remained undetected [1].
  • Dipstick leukocyte esterase activity in first-catch urine specimens. A useful screening test for detecting sexually transmitted disease in the adolescent male [2].
  • Urinalysis is also of great value in symptomatic patients; the presence of pyuria (and possibly indirect quantitation of pyuria by the leukocyte esterase test) is a reliable indicator of treatable infection, and its absence indicates infection is not present [3].
  • RESULTS: Of 4757 arrestees screened, 82 (1.7%) had untreated syphilis, and, of 4174 male arrestees screened, 541 (13%) had a positive leukocyte esterase test [4].

High impact information on CTA_0078


Chemical compound and disease context of CTA_0078


Biological context of CTA_0078


Analytical, diagnostic and therapeutic context of CTA_0078


  1. Urinary leukocyte esterase screening test for asymptomatic chlamydial and gonococcal infections in males. Shafer, M.A., Schachter, J., Moscicki, A.B., Weiss, A., Shalwitz, J., Vaughan, E., Millstein, S.G. JAMA (1989) [Pubmed]
  2. Dipstick leukocyte esterase activity in first-catch urine specimens. A useful screening test for detecting sexually transmitted disease in the adolescent male. Sadof, M.D., Woods, E.R., Emans, S.J. JAMA (1987) [Pubmed]
  3. Urinalysis and urine culture in women with dysuria. Komaroff, A.L. Ann. Intern. Med. (1986) [Pubmed]
  4. Rapid screening and treatment for sexually transmitted diseases in arrestees: a feasible control measure. Beltrami, J.F., Cohen, D.A., Hamrick, J.T., Farley, T.A. American journal of public health. (1997) [Pubmed]
  5. Urinary tract infection in patients with acute non-gonococcal urethritis. Leung, A., Taylor, S., Smith, A., Spencer, R., Horner, P. International journal of STD & AIDS. (2002) [Pubmed]
  6. Urinary leukocyte esterase screening for asymptomatic sexually transmitted disease in adolescent males. Werner, M.J., Biro, F.M. The Journal of adolescent health : official publication of the Society for Adolescent Medicine. (1991) [Pubmed]
  7. The usefulness of screening for chlamydial trachomatis infection with cervical mucus leukocyte esterase. el-Shourbagy, M., Diab, K.M., Abdalla, M.Y., el-Salam, M.A., Mohasb, S.H. J. Obstet. Gynaecol. Res. (1998) [Pubmed]
  8. Methods for the detection of male genital tract inflammation. Wolff, H. Andrologia (1998) [Pubmed]
  9. Urethritis associated with Chlamydia trachomatis: comparison of leukocyte esterase dipstick test of first-voided urine and methylene blue-stained urethral smear as predictors of chlamydial infection. Hedin, G., Abrahamsson, G., Dahlberg, E. APMIS (2001) [Pubmed]
  10. Young women with symptoms of urinary tract infection. Prevalence and diagnosis of chlamydial infection and evaluation of rapid screening of bacteriuria. Osterberg, E., Aspevall, O., Grillner, L., Persson, E. Scandinavian journal of primary health care. (1996) [Pubmed]
  11. Impact of urine collection order on the ability of assays to identify Chlamydia trachomatis infections in men. Chernesky, M., Jang, D., Chong, S., Sellors, J., Mahony, J. Sexually transmitted diseases. (2003) [Pubmed]
  12. Community-based urine screening for Chlamydia trachomatis with a ligase chain reaction assay. Marrazzo, J.M., White, C.L., Krekeler, B., Celum, C.L., Lafferty, W.E., Stamm, W.E., Handsfield, H.H. Ann. Intern. Med. (1997) [Pubmed]
  13. Use of a urine enzyme immunoassay as a diagnostic tool for Chlamydia trachomatis urethritis in men. Schwebke, J.R., Clark, A.M., Pettinger, M.B., Nsubga, P., Stamm, W.E. J. Clin. Microbiol. (1991) [Pubmed]
  14. Predicting Neisseria gonorrhoeae and Chlamydia trachomatis infection using risk scores, physical examination, microscopy, and leukocyte esterase urine dipsticks among asymptomatic women attending a family planning clinic in Kenya. Tyndall, M.W., Kidula, N., Sande, J., Ombette, J., Temmerman, M. Sexually transmitted diseases. (1999) [Pubmed]
  15. Non-invasive sampling for detection of genital infection with Chlamydia trachomatis in males utilising urinary leukocyte esterase tests and immunoassays. Domeika, M.A., Bassiri, M., Mårdh, P.A. Infection (1994) [Pubmed]
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