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MeSH Review

Ligase Chain Reaction

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Disease relevance of Ligase Chain Reaction


High impact information on Ligase Chain Reaction


Chemical compound and disease context of Ligase Chain Reaction

  • We assessed the correlation between ligase chain reaction (LCR) on first void urine (FVU) and cultures of urethral and cervical swabs to detect chlamydia during three post-treatment follow up visits for 10 men and 19 women with genital chlamydial infections who had been treated with azithromycin or doxcycline [11].

Biological context of Ligase Chain Reaction


Associations of Ligase Chain Reaction with chemical compounds

  • The cellular adequacies of 1,633 female endocervical swab specimens were assessed and compared with the results of C. trachomatis detection obtained by ligase chain reaction (LCR; Abbott Laboratories) [17].
  • OBJECTIVE: To assess the cost-effectiveness of three interventions for C. trachomatis infections in women beginning Army training: 1) screening using urine ligase chain reaction (LCR) by age, 2) unrestricted testing using urine LCR, and 3) universal antibiotic treatment with azithromycin [18].
  • Therefore, we have developed a new specific and sensitive method--a ligase chain reaction (LCR) assay--for detection of frequently encountered 594 mutated codon in ganciclovir (GCV) resistant virus [19].

Gene context of Ligase Chain Reaction


Analytical, diagnostic and therapeutic context of Ligase Chain Reaction


  1. Detection of Chlamydia trachomatis in urine samples by nucleic acid tests: comparison with culture and enzyme immunoassay of genital swab specimens. Schepetiuk, S., Kok, T., Martin, L., Waddell, R., Higgins, G. J. Clin. Microbiol. (1997) [Pubmed]
  2. Multicenter evaluation of the Abbott LCx Mycobacterium tuberculosis ligase chain reaction assay. Lumb, R., Davies, K., Dawson, D., Gibb, R., Gottlieb, T., Kershaw, C., Kociuba, K., Nimmo, G., Sangster, N., Worthington, M., Bastian, I. J. Clin. Microbiol. (1999) [Pubmed]
  3. Clinical utility of a commercial ligase chain reaction kit for the diagnosis of smear-negative pulmonary tuberculosis. Kwiatkowska, S., Marczak, J., Zieba, M., Nowak, D. The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease. (1999) [Pubmed]
  4. Associations between Mycoplasma genitalium, Chlamydia trachomatis and pelvic inflammatory disease. Simms, I., Eastick, K., Mallinson, H., Thomas, K., Gokhale, R., Hay, P., Herring, A., Rogers, P.A. J. Clin. Pathol. (2003) [Pubmed]
  5. Evaluation of the Abbott LCx Mycobacterium tuberculosis assay in comparison with culture methods in selected Italian patients. Fadda, G., Ardito, F., Sanguinetti, M., Posteraro, B., Ortona, L., Chezzi, C., Polonelli, L., Dettori, G., Conti, S., Fanti, F., Galli, C. New Microbiol. (1998) [Pubmed]
  6. Community-based urine screening for Chlamydia trachomatis with a ligase chain reaction assay. Marrazzo, J.M., White, C.L., Krekeler, B., Celum, C.L., Lafferty, W.E., Stamm, W.E., Handsfield, H.H. Ann. Intern. Med. (1997) [Pubmed]
  7. Deletion detection in the dystrophin gene by multiplex gap ligase chain reaction and immunochromatographic strip technology. Jou, C., Rhoads, J., Bouma, S., Ching, S., Hoijer, J., Schroeder-Poliak, P., Zaun, P., Smith, S., Richards, S., Caskey, C.T. Hum. Mutat. (1995) [Pubmed]
  8. Nucleic acid amplification technologies. Abramson, R.D., Myers, T.W. Curr. Opin. Biotechnol. (1993) [Pubmed]
  9. Cloning of two novel growth hormone transcripts expressed in human placenta. Boguszewski, C.L., Svensson, P.A., Jansson, T., Clark, R., Carlsson, L.M., Carlsson, B. J. Clin. Endocrinol. Metab. (1998) [Pubmed]
  10. Significant reduction in inflammatory response in the macaque model of chlamydial pelvic inflammatory disease with azithromycin treatment. Patton, D.L., Sweeney, Y.T., Stamm, W.E. J. Infect. Dis. (2005) [Pubmed]
  11. Correlation between culture testing of swabs and ligase chain reaction of first void urine from patients recently treated for Chlamydia trachomatis. Jang, D., Sellors, J., Howard, M., Mahony, J., Frost, E., Patrick, D., Bouchard, C., Dubois, J., Scholar, L., Chernesky, M. Sexually transmitted infections. (2003) [Pubmed]
  12. Urinary inhibitors of polymerase chain reaction and ligase chain reaction and testing of multiple specimens may contribute to lower assay sensitivities for diagnosing Chlamydia trachomatis infected women. Chernesky, M.A., Jang, D., Sellors, J., Luinstra, K., Chong, S., Castriciano, S., Mahony, J.B. Mol. Cell. Probes (1997) [Pubmed]
  13. Mutational activation of K-ras in nonneoplastic exocrine pancreatic lesions in relation to cigarette smoking status. Berger, D.H., Chang, H., Wood, M., Huang, L., Heath, C.W., Lehman, T., Ruggeri, B.A. Cancer (1999) [Pubmed]
  14. Screening of mutations in the ras family of oncogenes by polymerase chain reaction-based ligase chain reaction. Martínez, A., Lehman, T.A., Modali, R., Mulshine, J.L. Methods Mol. Med. (2003) [Pubmed]
  15. A novel clonality assay based on transcriptional polymorphism of X chromosome gene p55. Luhovy, M., Liu, Y., Belickova, M., Prchal, J.F., Prchal, J.T. Biol. Blood Marrow Transplant. (1995) [Pubmed]
  16. HFE genotype and parameters of iron metabolism in German first-time blood donors - evidence for an increased transferrin saturation in C282Y heterozygotes. Raddatz, D., Legler, T., Lynen, R., Addicks, N., Ramadori, G. Zeitschrift für Gastroenterologie. (2003) [Pubmed]
  17. Effect of endocervical specimen adequacy on ligase chain reaction detection of Chlamydia trachomatis. Loeffelholz, M.J., Jirsa, S.J., Teske, R.K., Woods, J.N. J. Clin. Microbiol. (2001) [Pubmed]
  18. Control of Chlamydia trachomatis infections in female army recruits: cost-effective screening and treatment in training cohorts to prevent pelvic inflammatory disease. Howell, M.R., Gaydos, J.C., McKee, K.T., Quinn, T.C., Gaydos, C.A. Sexually transmitted diseases. (1999) [Pubmed]
  19. Value of a ligase chain reaction assay for detection of ganciclovir resistance-related mutation 594 in UL97 gene of human cytomegalovirus. Bourgeois, C., Sixt, N., Bour, J.B., Pothier, P. J. Virol. Methods (1997) [Pubmed]
  20. Ligase chain reaction assay for human mutations: the Sickle Cell by LCR assay. Reyes, A.A., Carrera, P., Cardillo, E., Ugozzoli, L., Lowery, J.D., Lin, C.I., Go, M., Ferrari, M., Wallace, R.B. Clin. Chem. (1997) [Pubmed]
  21. Urine-based screening for Chlamydia trachomatis in men attending sexually transmitted disease clinics. Marrazzo, J.M., Whittington, W.L., Celum, C.L., Handsfield, H.H., Clark, A., Cles, L., Krekeler, B., Stamm, W.E. Sexually transmitted diseases. (2001) [Pubmed]
  22. Cloning, overexpression and nucleotide sequence of a thermostable DNA ligase-encoding gene. Barany, F., Gelfand, D.H. Gene (1991) [Pubmed]
  23. Evaluation of three nucleic acid amplification methods for direct detection of Mycobacterium tuberculosis complex in respiratory specimens. Wang, S.X., Tay, L. J. Clin. Microbiol. (1999) [Pubmed]
  24. Detection of K-ras oncogene mutations by polymerase chain reaction-based ligase chain reaction. Lehman, T.A., Scott, F., Seddon, M., Kelly, K., Dempsey, E.C., Wilson, V.L., Mulshine, J.L., Modali, R. Anal. Biochem. (1996) [Pubmed]
  25. Cost-effectiveness of partner pharmacotherapy in screening women for asymptomatic infection with Chlamydia Trachomatis. Postma, M.J., Welte, R., van den Hoek, J.A., van Doornum, G.J., Jager, H.C., Coutinho, R.A. Value in health : the journal of the International Society for Pharmacoeconomics and Outcomes Research. (2001) [Pubmed]
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