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MeSH Review


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Disease relevance of Pyuria


High impact information on Pyuria

  • The prevalence of pyuria among placebo patients increased from 11% to 42% while the catheter was in place; by contrast, the rate of pyuria was 11% or less in patients receiving ciprofloxacin (RR 4.0 [2.1-7.3]) [6].
  • As the bacterial count increased, the association between these organisms and symptoms increased, and a step-wise increase occurred in the frequency and magnitude of pyuria, but the specific gravity and urine creatinine levels remained unchanged [7].
  • Urinalysis is also of great value in symptomatic patients; the presence of pyuria (and possibly indirect quantitation of pyuria by the leukocyte esterase test) is a reliable indicator of treatable infection, and its absence indicates infection is not present [8].
  • Two-hundred nine patients with symptoms of acute urinary tract infection and pyuria were randomized to 400 mg of administered norfloxacin twice daily for three days, or 800 mg of sulfamethoxazole and 160 mg of trimethoprim administered twice daily for ten days [9].
  • Body temperature, CRP, ESR, pyuria, and renal concentrating capacity were analyzed in 692 children with first-time urinary tract infections [10].

Chemical compound and disease context of Pyuria

  • The Clinitek leukocyte esterase, nitrite, and blood methods were less sensitive than microscopic methods for detection of pyuria, bacteriuria, and hematuria, respectively [11].
  • Quantitative assessment of pyuria revealed a significant drop in the rate of excretion of white cells to near normal levels not only in patients who were cured but also in others, a finding which suggests that the infectious process had been affected by amikacin in all cases [12].
  • Adding urine culture for patients with pyuria had a marginal cost of $34 to $107 per SDA, which fell to $40/SDA when the prevalence of resistance to trimethoprim-sulfamethoxazole exceeded 40% [13].
  • Bacteriuria and pyuria were diagnosed, and cefazolin was initiated [14].
  • Pyuria in patients treated with indinavir is associated with renal dysfunction [15].

Biological context of Pyuria

  • There was no correlation between TH distribution and the degree of tubulointerstitial damage (p greater than 0.5), urinary TH excretion (p greater than 0.05), urinary beta 2-microglobulin excretion (p greater than 0.05), glomerular filtration rate, urinary concentrating ability, or the incidence of pyuria [16].

Anatomical context of Pyuria


Gene context of Pyuria

  • In the group with urinary infection an increased CEA level in urine, after antiphlogistic therapy, was found in 5 cases, inflammatory cells in 12 cases, pyuria in 8 cases and suspect cells were found in 6 cases in the group with urinary infection [19].
  • We should also note microscopic pyuria in such patients and subsequently perform C. trachomatis polymerase chain reaction test using urine initially as a noninvasive examination before cystourethroscopy [20].
  • Pyuria, dysuria, and frequency may be absent in patients with UTI's or present in patients without UTI's. Therefore, a UTI must be bacteriologically diagnosed as greater than 100,000 organisms/ml, usually of a single organism, in a properly obtained urine specimen [21].
  • OBJECTIVE: The aim of this study was to evaluate prospectively the impact of bacteriuria with or without pyuria and/or detrusor pressure on renal tubular function in patients with secondary vesicoureteral reflux [22].
  • A 69-year-old man with glucose-6-phosphate dehydrogenase deficiency was treated with nitrofurantoin for pyuria [23].

Analytical, diagnostic and therapeutic context of Pyuria


  1. Apparent prevalence of curable hypertension in the Hypertension Detection and Follow-up Program. Lewin, A., Blaufox, M.D., Castle, H., Entwisle, G., Langford, H. Arch. Intern. Med. (1985) [Pubmed]
  2. Single-dose amoxicillin therapy of acute uncomplicated urinary tract infections in women. Tolkoff-Rubin, N.E., Wilson, M.E., Zuromskis, P., Jacoby, I., Martin, A.R., Rubin, R.H. Antimicrob. Agents Chemother. (1984) [Pubmed]
  3. Clinical features of tiaprofenic acid (surgam) associated cystitis and a study of risk factors for its development. Buchbinder, R., Forbes, A., Kobben, F., Boyd, I., Snow, R.M., McNeil, J.J. Journal of clinical epidemiology. (2000) [Pubmed]
  4. The differentiation of classic Kawasaki disease, atypical Kawasaki disease, and acute adenoviral infection: use of clinical features and a rapid direct fluorescent antigen test. Barone, S.R., Pontrelli, L.R., Krilov, L.R. Archives of pediatrics & adolescent medicine. (2000) [Pubmed]
  5. Bowel perforation and interstitial cystitis in childhood systemic lupus erythematosus. Eberhard, A., Shore, A., Silverman, E., Laxer, R. J. Rheumatol. (1991) [Pubmed]
  6. Prophylactic ciprofloxacin for catheter-associated urinary-tract infection. van der Wall, E., Verkooyen, R.P., Mintjes-de Groot, J., Oostinga, J., van Dijk, A., Hustinx, W.N., Verbrugh, H.A. Lancet (1992) [Pubmed]
  7. A reassessment of the importance of "low-count" bacteriuria in young women with acute urinary symptoms. Kunin, C.M., White, L.V., Hua, T.H. Ann. Intern. Med. (1993) [Pubmed]
  8. Urinalysis and urine culture in women with dysuria. Komaroff, A.L. Ann. Intern. Med. (1986) [Pubmed]
  9. A multicenter comparative trial of three-day norfloxacin vs ten-day sulfamethoxazole and trimethoprim for the treatment of uncomplicated urinary tract infections. Stein, G.E., Mummaw, N., Goldstein, E.J., Boyko, E.J., Reller, L.B., Kurtz, T.O., Miller, K., Cox, C.E. Arch. Intern. Med. (1987) [Pubmed]
  10. Dependence among host response parameters used to diagnose urinary tract infection. de Man, P., Jodal, U., Svanborg, C. J. Infect. Dis. (1991) [Pubmed]
  11. The Ames Clinitek 200/Multistix 9 urinalysis method compared with manual and microscopic methods. Grinstead, G.F., Scott, R.E., Stevens, B.S., Ward, V.L., Wilson, D.M. Clin. Chem. (1987) [Pubmed]
  12. Pharmacokinetics of amikacin for treatment of urinary tract infections in patients with reduced renal function. Höffler, D., Koeppe, P., Demers, H.G. J. Infect. Dis. (1976) [Pubmed]
  13. All dysuria is local. A cost-effectiveness model for designing site-specific management algorithms. Rothberg, M.B., Wong, J.B. Journal of general internal medicine : official journal of the Society for Research and Education in Primary Care Internal Medicine. (2004) [Pubmed]
  14. Sacroiliitis associated with pyelonephritis in pregnancy. Egerman, R.S., Mabie, W.C., Eifrid, M., Whitnack, E., Sibai, B.M. Obstetrics and gynecology. (1995) [Pubmed]
  15. Pyuria in patients treated with indinavir is associated with renal dysfunction. Sarcletti, M., Petter, A., Romani, N., Lhotta, K., König, P., Maier, H., Zangerle, R. Clin. Nephrol. (2000) [Pubmed]
  16. Relationship of abnormal Tamm-Horsfall glycoprotein localization to renal morphology and function. Chambers, R., Groufsky, A., Hunt, J.S., Lynn, K.L., McGiven, A.R. Clin. Nephrol. (1986) [Pubmed]
  17. Indinavir-associated interstitial nephritis and urothelial inflammation: clinical and cytologic findings. Kopp, J.B., Falloon, J., Filie, A., Abati, A., King, C., Hortin, G.L., Mican, J.M., Vaughan, E., Miller, K.D. Clin. Infect. Dis. (2002) [Pubmed]
  18. Renal transitional cell carcinoma and choristoma in a degu (Octodon degus). Lester, P.A., Rush, H.G., Sigler, R.E. Contemporary topics in laboratory animal science / American Association for Laboratory Animal Science. (2005) [Pubmed]
  19. Diagnostic value of urine cytology and urine carcinoembryonic antigen (CEA) level in the distinction between bladder cancer and urinary tract infection. Gajda, M., Tyloch, F., Jóźwicki, W., Tyloch, J., Sujkowska, R., Skok, Z. International journal of occupational medicine and environmental health. (1995) [Pubmed]
  20. Bullous lesion in the prostatic urethra: morphological change caused by putative chlamydial infection. Kamura, K., Nishimura, T., Okamoto, T., Noguchi, M., Hamaguchi, K. J. Urol. (2003) [Pubmed]
  21. The dipslide in diagnosis of urinary tract infections. Adelman, R.D. The Journal of family practice. (1976) [Pubmed]
  22. Impact of urinary tract infection and detrusor pressure on renal tubular function in patients with vesicoureteral reflux. Everaert, K., Van Laecke, E., Dekuyper, P., Hoebeke, P., Delanghe, J., Oosterlinck, W., Vande Walle, J. Eur. Urol. (2001) [Pubmed]
  23. Hyperlactatemia and hemolysis in G6PD deficiency after nitrofurantoin ingestion. Lavelle, K.J., Atkinson, K.F., Kleit, S.A. Am. J. Med. Sci. (1976) [Pubmed]
  24. Persistent flank pain, low-grade fever, and malaise in a woman treated with indinavir. Sarcletti, M., Zangerle, R. AIDS patient care and STDs. (1999) [Pubmed]
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