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Gene Review

tk1a-A  -  tyrosine kinase

Xenopus laevis

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High impact information on tk1a-A

  • This constitutes a simplified system with which to study the signal transduction pathway from the DNA template to the tyrosine kinase responsible for inhibiting p34cdc2 activity [1].
  • Furthermore, we have shown that low levels of M13 single-stranded DNA and high levels of double-stranded plasmid DNA can elevate the tyrosine kinase activity responsible for phosphorylating p34cdc2, thereby inactivating maturation-promoting factor and inhibiting entry into mitosis [1].
  • This is the first demonstration that a tyrosine kinase oncogene product, p65tpr-met, can induce meiotic maturation in Xenopus oocytes and activate MPF through a mos-dependent pathway, possibly the insulin or insulinlike growth factor 1 pathway [2].
  • tpr-met, a tyrosine kinase oncogene, is the activated form of the met proto-oncogene that encodes the receptor for hepatocyte growth factor/scatter factor [2].
  • The Xenopus annexin II heavy chain lacks the highly conserved tyrosine at position 23 which is the site of src oncogene tyrosine kinase phosphorylation in the murine protein [3].

Biological context of tk1a-A


Anatomical context of tk1a-A

  • To determine whether increases in tyrosine kinase activity are part of this pathway, we microinjected tyrosine kinase inhibitors into unfertilized eggs [7].
  • Four different ligand-receptor binding pairs of the GDNF (glial cell line-derived neurotrophic factor) family exist in mammals, and they all signal via the transmembrane RET receptor tyrosine kinase [8].

Associations of tk1a-A with chemical compounds


Other interactions of tk1a-A

  • Our results suggest that the activation of PKC and tyrosine kinase but not actin reorganization plays a role in the SSC potentiating action of fibronectin [13].

Analytical, diagnostic and therapeutic context of tk1a-A


  1. In vitro cell cycle arrest induced by using artificial DNA templates. Kornbluth, S., Smythe, C., Newport, J.W. Mol. Cell. Biol. (1992) [Pubmed]
  2. tpr-met oncogene product induces maturation-producing factor activation in Xenopus oocytes. Daar, I.O., White, G.A., Schuh, S.M., Ferris, D.K., Vande Woude, G.F. Mol. Cell. Biol. (1991) [Pubmed]
  3. Xenopus annexin II (calpactin I) heavy chain has a distinct amino terminus. Izant, J.G., Bryson, L.J. J. Biol. Chem. (1991) [Pubmed]
  4. Signal transduction pathways leading to Ca2+ release in a vertebrate model system: lessons from Xenopus eggs. Sato, K., Fukami, Y., Stith, B.J. Semin. Cell Dev. Biol. (2006) [Pubmed]
  5. Erks: their fifteen minutes has arrived. Crews, C.M., Alessandrini, A., Erikson, R.L. Cell Growth Differ. (1992) [Pubmed]
  6. Studying fertilization in cell-free extracts: focusing on membrane/lipid raft functions and proteomics. Sato, K., Yoshino, K., Tokmakov, A.A., Iwasaki, T., Yonezawa, K., Fukami, Y. Methods Mol. Biol. (2006) [Pubmed]
  7. Tyrosine kinase inhibitors block sperm-induced egg activation in Xenopus laevis. Glahn, D., Mark, S.D., Behr, R.K., Nuccitelli, R. Dev. Biol. (1999) [Pubmed]
  8. Evolution of the GDNF family ligands and receptors. Airaksinen, M.S., Holm, L., Hätinen, T. Brain Behav. Evol. (2006) [Pubmed]
  9. Ca2+ oscillations induced by fibroblast growth factor 2 in Xenopus oocytes expressing fibroblast growth factor receptors. Malo, M., Browaeys-Poly, E., Fournier, F., Cailliau, K., Vilain, J.P. Mol. Membr. Biol. (1997) [Pubmed]
  10. Characterization of the intracellular signalling pathways that underlie growth-factor-stimulated glucose transport in Xenopus oocytes: evidence for ras- and rho-dependent pathways of phosphatidylinositol 3-kinase activation. Thomson, F.J., Jess, T.J., Moyes, C., Plevin, R., Gould, G.W. Biochem. J. (1997) [Pubmed]
  11. Direct action of genistein on CFTR. Weinreich, F., Wood, P.G., Riordan, J.R., Nagel, G. Pflugers Arch. (1997) [Pubmed]
  12. Caffeine overrides the S-phase cell cycle block in sea urchin embryos. Patel, R., Wright, E.M., Whitaker, M. Zygote (1997) [Pubmed]
  13. Regulation of acetylcholine release by extracellular matrix proteins at developing motoneurons in Xenopus cell cultures. Fu, W.M., Shih, Y.C., Chen, S.Y., Tsai, P.H. J. Neurosci. Res. (2001) [Pubmed]
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