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Gene Review

CYB_0575  -  phycobilisome protein

Synechococcus sp. JA-2-3Ba(2-13)

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Disease relevance of CYB_0575

  • A terminal energy acceptor of the phycobilisome: the 75,000-dalton polypeptide of Synechococcus 6301 phycobilisomes--a new biliprotein [1].
  • In cyanobacteria, light energy is mainly harvested by the phycobiliproteins that form the phycobilisome rods, and funneled to the photosynthetic reaction centers through the core components [2].
  • Differences in the absorption properties and cellular costs between chlorophyll a(2)/b(2) and phycobilisome antennas in extant Prochlorococcus and Synechococcus appear to play a role in differentiating their ecological niches in the ocean environment [3].
  • The linker and anchor subunits from the morphologically different phycobilisome of Synechocystis sp. strain PCC6714 were also shown to be concanavalin A reactive [4].
  • Phycobilisome degradation is an ordered proteolytic process, visible by a color change of the cyanobacterial cell from blue-green to yellow-green (chlorosis) [5].

High impact information on CYB_0575


Biological context of CYB_0575


Associations of CYB_0575 with chemical compounds

  • Four phycobilisome-associated proteins were found to be specifically reactive with the lectin concanavalin A after subunits of isolated Anacystis nidulans R 2 phycobilisomes were separated on polyacrylamide gels and transferred onto nitrocellulose [12].
  • Chemical analysis of the total isolated phycobilisome material indicated the presence of glucose (approx. 1.5% by wt) and N-acetylgalactosamine (0.15% by wt), consistent with our proposal that the concanavalin A-reactive polypeptides contain covalently linked, glucose-containing polysaccharides [12].
  • Phycobilisome polypeptides separated by polyacrylamide gel electrophoresis in the presence of sodium dodecyl sulfate were subjected to various glycoprotein-specific staining procedures [13].
  • Structurally, the linker polypeptide should disrupt the C3 symmetry in the central cavity of the associated phycobiliprotein and this asymmetric interaction should serve to guide the transfer of excitation energy along PBS rods toward the core elements [14].

Analytical, diagnostic and therapeutic context of CYB_0575

  • Spectroscopic studies that phycocyanin is in the hexamer form, (alpha beta)6, in intact phycobilisomes, and that the circular dichroism and absorbance of this aggregate are little affected by incorporation into the phycobilisome structure [15].
  • Southern blot analysis showed that the genetic organization of the phycobilisome rod operon is very similar in the two strains [16].


  1. A terminal energy acceptor of the phycobilisome: the 75,000-dalton polypeptide of Synechococcus 6301 phycobilisomes--a new biliprotein. Lundell, D.J., Yamanaka, G., Glazer, A.N. J. Cell Biol. (1981) [Pubmed]
  2. The "anchor polypeptide" of cyanobacterial phycobilisomes. Molecular characterization of the Synechococcus sp. PCC 6301 apce gene. Capuano, V., Braux, A.S., Tandeau de Marsac, N., Houmard, J. J. Biol. Chem. (1991) [Pubmed]
  3. Cyanobacterial photosynthesis in the oceans: the origins and significance of divergent light-harvesting strategies. Ting, C.S., Rocap, G., King, J., Chisholm, S.W. Trends Microbiol. (2002) [Pubmed]
  4. Characterization of phycobilisome glycoproteins in the cyanobacterium Anacystis nidulans R2. Riethman, H.C., Mawhinney, T.P., Sherman, L.A. J. Bacteriol. (1988) [Pubmed]
  5. Expression of two nblA-homologous genes is required for phycobilisome degradation in nitrogen-starved Synechocystis sp. PCC6803. Baier, K., Nicklisch, S., Grundner, C., Reinecke, J., Lockau, W. FEMS Microbiol. Lett. (2001) [Pubmed]
  6. Diffusion of phycobilisomes on the thylakoid membranes of the cyanobacterium Synechococcus 7942. Effects of phycobilisome size, temperature, and membrane lipid composition. Sarcina, M., Tobin, M.J., Mullineaux, C.W. J. Biol. Chem. (2001) [Pubmed]
  7. Rod structure of a phycoerythrin II-containing phycobilisome. I. Organization and sequence of the gene cluster encoding the major phycobiliprotein rod components in the genome of marine Synechococcus sp. WH8020. Wilbanks, S.M., Glazer, A.N. J. Biol. Chem. (1993) [Pubmed]
  8. NblC, a novel component required for pigment degradation during starvation in Synechococcus PCC 7942. Sendersky, E., Lahmi, R., Shaltiel, J., Perelman, A., Schwarz, R. Mol. Microbiol. (2005) [Pubmed]
  9. Genetic analysis of phycobilisome mutants in the cyanobacterium Synechococcus species PCC 6301. Kalla, R., Lind, L.K., Gustafsson, P. Mol. Microbiol. (1989) [Pubmed]
  10. Phycobiliprotein methylation. Effect of the gamma-N-methylasparagine residue on energy transfer in phycocyanin and the phycobilisome. Swanson, R.V., Glazer, A.N. J. Mol. Biol. (1990) [Pubmed]
  11. State transitions in a phycobilisome-less mutant of the cyanobacterium Synechococcus sp. PCC 7002. Bruce, D., Brimble, S., Bryant, D.A. Biochim. Biophys. Acta (1989) [Pubmed]
  12. Phycobilisome-associated glycoproteins in the cyanobacterium Anacystis nidulans R 2. Riethman, H.C., Mawhinney, T.P., Sherman, L.A. FEBS Lett. (1987) [Pubmed]
  13. Absence of glycosylation on cyanobacterial phycobilisome linker polypeptides and rhodophytan phycoerythrins. Fairchild, C.D., Jones, I.K., Glazer, A.N. J. Bacteriol. (1991) [Pubmed]
  14. Spectroscopic study of the light-harvesting protein C-phycocyanin associated with colorless linker peptides. Pizarro, S.A., Sauer, K. Photochem. Photobiol. (2001) [Pubmed]
  15. Cyanobacterial phycobilisomes. Characterization of the phycobilisomes of Synechococcus sp. 6301. Yamanaka, G., Glazer, A.N., Williams, R.C. J. Biol. Chem. (1978) [Pubmed]
  16. Cloning of the phycobilisome rod linker genes from the cyanobacterium Synechococcus sp. PCC 6301 and their inactivation in Synechococcus sp. PCC 7942. Bhalerao, R.P., Lind, L.K., Persson, C.E., Gustafsson, P. Mol. Gen. Genet. (1993) [Pubmed]
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