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ALCAM  -  activated leukocyte cell adhesion molecule

Gallus gallus

Synonyms: BEN, DM-GRASP, JC7, SC1
 
 
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Disease relevance of ALCAM

  • Northern (RNA) analysis using a probe from the DM-GRASP gene identified a 5.3-kb transcript in mRNA from bursa, thymus, and brain as well as from v-rel-induced B-cell lymphomas but not from bursal B cells [1].
  • This structure has been described previously for the human MUC18 melanoma antigen (31% amino acid identity) and chicken and rat versions of a neural adhesion molecule referred to as SC1/DM-GRASP/BEN or KG-CAM, respectively (26% amino acid identity) [2].
  • This glycoprotein, identified by the JC7 monoclonal antibody, is present on the surface of axons and cell bodies of developing spinal motor neurons, dorsal root ganglion sensory neurons, sympathetic and parasympathetic neurons, and a small subset of brain neurons [3].
 

High impact information on ALCAM

 

Biological context of ALCAM

 

Anatomical context of ALCAM

 

Analytical, diagnostic and therapeutic context of ALCAM

References

  1. v-rel Induces ectopic expression of an adhesion molecule, DM-GRASP, during B-lymphoma development. Zhang, G., Slaughter, C., Humphries, E.H. Mol. Cell. Biol. (1995) [Pubmed]
  2. Molecular cloning of the B-CAM cell surface glycoprotein of epithelial cancers: a novel member of the immunoglobulin superfamily. Campbell, I.G., Foulkes, W.D., Senger, G., Trowsdale, J., Garin-Chesa, P., Rettig, W.J. Cancer Res. (1994) [Pubmed]
  3. Characterization of a cell surface adhesion molecule expressed by a subset of developing chick neurons. el-Deeb, S., Thompson, S.C., Covault, J. Dev. Biol. (1992) [Pubmed]
  4. DM-GRASP, a novel immunoglobulin superfamily axonal surface protein that supports neurite extension. Burns, F.R., von Kannen, S., Guy, L., Raper, J.A., Kamholz, J., Chang, S. Neuron (1991) [Pubmed]
  5. Heterophilic interactions of DM-GRASP: GRASP-NgCAM interactions involved in neurite extension. DeBernardo, A.P., Chang, S. J. Cell Biol. (1996) [Pubmed]
  6. Neurolin, a cell surface glycoprotein on growing retinal axons in the goldfish visual system, is reexpressed during retinal axonal regeneration. Paschke, K.A., Lottspeich, F., Stuermer, C.A. J. Cell Biol. (1992) [Pubmed]
  7. BEN/SC1/DM-GRASP, a homophilic adhesion molecule, is required for in vitro myeloid colony formation by avian hemopoietic progenitors. Corbel, C., Pourquié, O., Cormier, F., Vaigot, P., Le Douarin, N.M. Proc. Natl. Acad. Sci. U.S.A. (1996) [Pubmed]
  8. BEN/SC1/DM-GRASP expression during neuromuscular development: a cell adhesion molecule regulated by innervation. Fournier-Thibault, C., Pourquié, O., Rouaud, T., Le Douarin, N.M. J. Neurosci. (1999) [Pubmed]
  9. DM-GRASP is necessary for nonradial cell migration during chick diencephalic development. Heffron, D.S., Golden, J.A. J. Neurosci. (2000) [Pubmed]
  10. Role of cell adhesion molecule DM-GRASP in growth and orientation of retinal ganglion cell axons. Avci, H.X., Zelina, P., Thelen, K., Pollerberg, G.E. Dev. Biol. (2004) [Pubmed]
  11. Regulation of SC1/DM-GRASP during the migration of motor neurons in the chick embryo brain stem. Simon, H., Guthrie, S., Lumsden, A. J. Neurobiol. (1994) [Pubmed]
 
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