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Gene Review

CST3  -  cystatin C

Gallus gallus

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Disease relevance of CST3


High impact information on CST3


Biological context of CST3


Anatomical context of CST3

  • A high degree of homology in the sequence was found between the colostrum inhibitor and human gamma-trace, human salivary acidic protein and chicken egg-white cystatin [11].
  • Cysteine-proteinases (CP) of the papain family can be affinity-adsorbed by egg white cystatin C coupled to Sepharose 4B, thus allowing their selective isolation from either tissue or cultured cell extracts as well as biolological fluids and culture media [12].

Associations of CST3 with chemical compounds


Other interactions of CST3


Analytical, diagnostic and therapeutic context of CST3


  1. Purification and characterization of a chicken egg white cystatin variant expressed in an Escherichia coli pIN-III-ompA system. Auerswald, E.A., Genenger, G., Mentele, R., Lenzen, S., Assfalg-Machleidt, I., Mitschang, L., Oschkinat, H., Fritz, H. Eur. J. Biochem. (1991) [Pubmed]
  2. A cysteine protease inhibitor stored in the large granules of horseshoe crab hemocytes: purification, characterization, cDNA cloning and tissue localization. Agarwala, K.L., Kawabata, S., Hirata, M., Miyagi, M., Tsunasawa, S., Iwanaga, S. J. Biochem. (1996) [Pubmed]
  3. The 2.0 A X-ray crystal structure of chicken egg white cystatin and its possible mode of interaction with cysteine proteinases. Bode, W., Engh, R., Musil, D., Thiele, U., Huber, R., Karshikov, A., Brzin, J., Kos, J., Turk, V. EMBO J. (1988) [Pubmed]
  4. Chicken egg white cystatin. Molecular cloning, nucleotide sequence, and tissue distribution. Colella, R., Sakaguchi, Y., Nagase, H., Bird, J.W. J. Biol. Chem. (1989) [Pubmed]
  5. Complete amino acid sequence of ananain and a comparison with stem bromelain and other plant cysteine proteases. Lee, K.L., Albee, K.L., Bernasconi, R.J., Edmunds, T. Biochem. J. (1997) [Pubmed]
  6. Cysteine proteinase inhibitors and ras gene products share the same biological activities including transforming activity toward NIH3T3 mouse fibroblasts and the differentiation-inducing activity toward PC12 rat pheochromocytoma cells. Hiwasa, T., Sawada, T., Sakiyama, S. Carcinogenesis (1990) [Pubmed]
  7. Fermenter production of an artificial fab fragment, rationally designed for the antigen cystatin, and its optimized crystallization through constant domain shuffling. Schiweck, W., Skerra, A. Proteins (1995) [Pubmed]
  8. Isolation and characterization of the chicken cystatin-encoding gene: mapping transcription start point and polyadenylation sites. Colella, R., Bird, J.W. Gene (1993) [Pubmed]
  9. Recombinant chicken egg white cystatin variants of the QLVSG region. Auerswald, E.A., Genenger, G., Assfalg-Machleidt, I., Machleidt, W., Engh, R.A., Fritz, H. Eur. J. Biochem. (1992) [Pubmed]
  10. Changes in chicken egg white cystatin concentration and isoforms during embryogenesis. Golab, K., Gburek, J., Gawel, A., Warwas, M. Br. Poult. Sci. (2001) [Pubmed]
  11. Complete amino acid sequence of bovine colostrum low-Mr cysteine proteinase inhibitor. Hirado, M., Tsunasawa, S., Sakiyama, F., Niinobe, M., Fujii, S. FEBS Lett. (1985) [Pubmed]
  12. A cystatin-based affinity procedure for the isolation and analysis of papain-like cysteine proteinases from tissue extracts. Tombaccini, D., Mocali, A., Weber, E., Paoletti, F. Anal. Biochem. (2001) [Pubmed]
  13. Mechanism of inhibition of papain by chicken egg white cystatin. Inhibition constants of N-terminally truncated forms and cyanogen bromide fragments of the inhibitor. Machleidt, W., Thiele, U., Laber, B., Assfalg-Machleidt, I., Esterl, A., Wiegand, G., Kos, J., Turk, V., Bode, W. FEBS Lett. (1989) [Pubmed]
  14. Recombinant Q53E- and Q53N--chicken egg white cystatin variants inhibit papain, actinidin and cathepsin B. Genenger, G., Lenzen, S., Mentele, R., Assfalg-Machleidt, I., Auerswald, E.A. Biomed. Biochim. Acta (1991) [Pubmed]
  15. The cysteine proteinase inhibitor chicken cystatin is a phosphoprotein. Laber, B., Krieglstein, K., Henschen, A., Kos, J., Turk, V., Huber, R., Bode, W. FEBS Lett. (1989) [Pubmed]
  16. Crystallization of chicken egg white cystatin, a low molecular weight protein inhibitor of cysteine proteinases, and preliminary X-ray diffraction data. Bode, W., Brzin, J., Turk, V. J. Mol. Biol. (1985) [Pubmed]
  17. Cystatin capture enzyme-linked immunosorbent assay for immunodiagnosis of human paragonimiasis and fascioliasis. Ikeda, T. Am. J. Trop. Med. Hyg. (1998) [Pubmed]
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