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Gene Review

Cst3  -  cystatin C

Rattus norvegicus

Synonyms: Cystatin-3, Cystatin-C
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Disease relevance of Cst3


Psychiatry related information on Cst3


High impact information on Cst3

  • We previously demonstrated increased expression of cystatin C, a protease inhibitor linked to both neurodegeneration and neurogenesis, during epileptogenesis in the rat hippocampus [7].
  • In patients with TLE, high cystatin C expression associated with greater numbers of polysialylated neural cell adhesion molecule-positive newborn cells in the molecular layer, although the overall number was decreased, indicating that the newborn cells migrate to abnormal locations in the epileptic dentate gyrus [7].
  • A selective Cat S inhibitor and the endogenous inhibitor cystatin C significantly attenuated SMC invasion across elastin gel [8].
  • Double-labeled fluorescence immunohistochemistry revealed that nigrostriatal neurons, astrocytes, and microglia contributed to the elevated level of cystatin C [2].
  • The results indicate that the 6-OHDA lesioning induced a relatively slow but sustained up-regulation of cystatin C expression and suggest that the inhibitor may exert a neuroprotective action on DA neurons [2].

Chemical compound and disease context of Cst3


Biological context of Cst3


Anatomical context of Cst3


Associations of Cst3 with chemical compounds


Other interactions of Cst3


Analytical, diagnostic and therapeutic context of Cst3


  1. Competition between albumin and low-molecular-weight proteins for renal tubular uptake in experimental nephropathies. Thielemans, N., Lauwerys, R., Bernard, A. Nephron (1994) [Pubmed]
  2. Cystatin C prevents degeneration of rat nigral dopaminergic neurons: in vitro and in vivo studies. Xu, L., Sheng, J., Tang, Z., Wu, X., Yu, Y., Guo, H., Shen, Y., Zhou, C., Paraoan, L., Zhou, J. Neurobiol. Dis. (2005) [Pubmed]
  3. Upregulation of cystatin C expression in the rat hippocampus during epileptogenesis in the amygdala stimulation model of temporal lobe epilepsy. Lukasiuk, K., Pirttilä, T.J., Pitkänen, A. Epilepsia (2002) [Pubmed]
  4. Cystatin C, a cysteine protease inhibitor, is persistently up-regulated in neurons and glia in a rat model for mesial temporal lobe epilepsy. Aronica, E., van Vliet, E.A., Hendriksen, E., Troost, D., Lopes da Silva, F.H., Gorter, J.A. Eur. J. Neurosci. (2001) [Pubmed]
  5. Cystatin C, a protease inhibitor, in degenerating rat hippocampal neurons following transient forebrain ischemia. Palm, D.E., Knuckey, N.W., Primiano, M.J., Spangenberger, A.G., Johanson, C.E. Brain Res. (1995) [Pubmed]
  6. Neuronal cell death induced by cystatin C in vivo and in cultured human CNS neurons is inhibited with cathepsin B. Nagai, A., Ryu, J.K., Terashima, M., Tanigawa, Y., Wakabayashi, K., McLarnon, J.G., Kobayashi, S., Masuda, J., Kim, S.U. Brain Res. (2005) [Pubmed]
  7. Cystatin C expression is associated with granule cell dispersion in epilepsy. Pirttilä, T.J., Manninen, A., Jutila, L., Nissinen, J., Kälviäinen, R., Vapalahti, M., Immonen, A., Paljärvi, L., Karkola, K., Alafuzoff, I., Mervaala, E., Pitkänen, A. Ann. Neurol. (2005) [Pubmed]
  8. Localization of cysteine protease, cathepsin S, to the surface of vascular smooth muscle cells by association with integrin alphanubeta3. Cheng, X.W., Kuzuya, M., Nakamura, K., Di, Q., Liu, Z., Sasaki, T., Kanda, S., Jin, H., Shi, G.P., Murohara, T., Yokota, M., Iguchi, A. Am. J. Pathol. (2006) [Pubmed]
  9. Cystatin C in a rat model of end-stage renal failure. Bökenkamp, A., Ciarimboli, G., Dieterich, C. Renal failure. (2001) [Pubmed]
  10. The cDNA structure and expression analysis of the genes for the cysteine proteinase inhibitor cystatin C and for beta 2-microglobulin in rat brain. Cole, T., Dickson, P.W., Esnard, F., Averill, S., Risbridger, G.P., Gauthier, F., Schreiber, G. Eur. J. Biochem. (1989) [Pubmed]
  11. Production of the cysteine proteinase inhibitor cystatin C by rat Sertoli cells. Esnard, A., Esnard, F., Guillou, F., Gauthier, F. FEBS Lett. (1992) [Pubmed]
  12. Expression of cystatin C prevents oxidative stress-induced death in PC12 cells. Nishiyama, K., Konishi, A., Nishio, C., Araki-Yoshida, K., Hatanaka, H., Kojima, M., Ohmiya, Y., Yamada, M., Koshimizu, H. Brain Res. Bull. (2005) [Pubmed]
  13. Demonstration of multiple novel glycoforms of the stem cell survival factor CCg. Dahl, A., Eriksson, P.S., Davidsson, P., Persson, A.I., Ekman, R., Westman-Brinkmalm, A. J. Neurosci. Res. (2004) [Pubmed]
  14. Processing of pro-CGRP in a rat medullary thyroid carcinoma cell line transfected with protease inhibitors. Johansen, T.E., Schifter, S., Vogel, C.K., Tolstoy, S., Schwartz, T.W. Mol. Cell. Endocrinol. (1991) [Pubmed]
  15. Characterization of progenitor-cell-specific genes identified by subtractive suppression hybridization. Cai, J., Xue, H., Zhan, M., Rao, M.S. Dev. Neurosci. (2004) [Pubmed]
  16. Genomic profiling of the neuronal target genes of the plasticity-related transcription factor -- Zif268. James, A.B., Conway, A.M., Morris, B.J. J. Neurochem. (2005) [Pubmed]
  17. Sertoli cell and germ cell cystatin C: stage-dependent expression of two distinct messenger ribonucleic acid transcripts in rat testes. Tsuruta, J.K., O'Brien, D.A., Griswold, M.D. Biol. Reprod. (1993) [Pubmed]
  18. Expression of the cysteine proteinase inhibitor cystatin C gene in rat heart: use of digoxigenin-labeled probes generated by polymerase chain reaction directly for in situ and northern blot hybridizations. Barka, T., van der Noen, H. J. Histochem. Cytochem. (1993) [Pubmed]
  19. Up-regulation of cystatin C by microglia in the rat facial nucleus following axotomy. Miyake, T., Gahara, Y., Nakayama, M., Yamada, H., Uwabe, K., Kitamura, T. Brain Res. Mol. Brain Res. (1996) [Pubmed]
  20. Changes in distribution of cystatin C, apolipoprotein E and ferritin in rat hypothalamus after hypophysectomy. Katakai, K., Shinoda, M., Kabeya, K., Watanabe, M., Ohe, Y., Mori, M., Ishikawa, K. J. Neuroendocrinol. (1997) [Pubmed]
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