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OPRK1  -  opioid receptor, kappa 1

Sus scrofa

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Disease relevance of OPRK1


Psychiatry related information on OPRK1


High impact information on OPRK1


Biological context of OPRK1


Anatomical context of OPRK1


Associations of OPRK1 with chemical compounds


Other interactions of OPRK1

  • On the other hand, [Cys8,Cys13]Dyn A1-13-NH2 and [D-Cys8,D-Cys13]Dyn A1-13-NH2 (5) display high kappa potencies and selectivities at the peripheral (GPI) but not at the central (GPB) kappa opioid receptor [19].

Analytical, diagnostic and therapeutic context of OPRK1


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  5. kappa-Opioid receptors also increase potassium conductance. Grudt, T.J., Williams, J.T. Proc. Natl. Acad. Sci. U.S.A. (1993) [Pubmed]
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  16. Role of blood-brain barrier P-glycoprotein in limiting brain accumulation and sedative side-effects of asimadoline, a peripherally acting analgaesic drug. Jonker, J.W., Wagenaar, E., van Deemter, L., Gottschlich, R., Bender, H.M., Dasenbrock, J., Schinkel, A.H. Br. J. Pharmacol. (1999) [Pubmed]
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  18. Pharmacological properties of R-84760, a novel kappa-opioid receptor agonist. Fujibayashi, K., Sakamoto, K., Watanabe, M., Iizuka, Y. Eur. J. Pharmacol. (1994) [Pubmed]
  19. Design and synthesis of highly potent and selective cyclic dynorphin A analogues. Kawasaki, A.M., Knapp, R.J., Kramer, T.H., Wire, W.S., Vasquez, O.S., Yamamura, H.I., Burks, T.F., Hruby, V.J. J. Med. Chem. (1990) [Pubmed]
  20. Inhibitory effects of opioids on voltage-dependent Ca(2+) channels and catecholamine secretion in cultured porcine adrenal chromaffin cells. Kitamura, G., Ohta, T., Kai, T., Kon, Y., Ito, S. Brain Res. (2002) [Pubmed]
  21. Inhibition by nociceptin on excitatory non-adrenergic non-cholinergic response in guinea pig airways. Fang, L.B., Wu, Y., Zhang, L.F., Fang, W.Q. Acta Pharmacol. Sin. (2001) [Pubmed]
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