The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
Gene Review

OPRK1  -  opioid receptor, kappa 1

Sus scrofa

This record was replaced with 100152118.
 
 
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.
 

Disease relevance of OPRK1

 

Psychiatry related information on OPRK1

 

High impact information on OPRK1

 

Biological context of OPRK1

 

Anatomical context of OPRK1

 

Associations of OPRK1 with chemical compounds

 

Other interactions of OPRK1

  • On the other hand, [Cys8,Cys13]Dyn A1-13-NH2 and [D-Cys8,D-Cys13]Dyn A1-13-NH2 (5) display high kappa potencies and selectivities at the peripheral (GPI) but not at the central (GPB) kappa opioid receptor [19].
 

Analytical, diagnostic and therapeutic context of OPRK1

References

  1. Role of kappa-opioid receptor activation in pharmacological preconditioning of swine. Coles, J.A., Sigg, D.C., Iaizzo, P.A. Am. J. Physiol. Heart Circ. Physiol. (2003) [Pubmed]
  2. Characterization of kappa1-opioid receptor binding in human insular cortex. Izenwasser, S., Staley, J.K., Cohn, S., Mash, D.C. Life Sci. (1999) [Pubmed]
  3. The molecular basis of opioid receptor function. Simonds, W.F. Endocr. Rev. (1988) [Pubmed]
  4. The kappa-opioid receptor is primarily postsynaptic: combined immunohistochemical localization of the receptor and endogenous opioids. Arvidsson, U., Riedl, M., Chakrabarti, S., Vulchanova, L., Lee, J.H., Nakano, A.H., Lin, X., Loh, H.H., Law, P.Y., Wessendorf, M.W. Proc. Natl. Acad. Sci. U.S.A. (1995) [Pubmed]
  5. kappa-Opioid receptors also increase potassium conductance. Grudt, T.J., Williams, J.T. Proc. Natl. Acad. Sci. U.S.A. (1993) [Pubmed]
  6. Agonist-induced phosphorylation of the kappa-opioid receptor. Appleyard, S.M., Patterson, T.A., Jin, W., Chavkin, C. J. Neurochem. (1997) [Pubmed]
  7. A monoclonal antibody recognizing kappa- but not mu- and delta-opioid receptors. Maderspach, K., Németh, K., Simon, J., Benyhe, S., Szücs, M., Wollemann, M. J. Neurochem. (1991) [Pubmed]
  8. Synthesis and opioid activity of 7-oxygenated 2,3,4,4a,5,6,7,7a-octahydro-1H-benzofuro[3,2-e]isoquinolin-9-ols. Cheng, C.Y., Hsin, L.W., Tsai, M.C., Schmidt, W.K., Smith, C., Tam, S.W. J. Med. Chem. (1994) [Pubmed]
  9. A subtype of kappa-opioid receptor mediates inhibition of high-affinity GTPase inherent in Gi1 in guinea pig cerebellar membranes. Ueda, H., Misawa, H., Fukushima, N., Katada, T., Ui, M., Satoh, M. J. Neurochem. (1996) [Pubmed]
  10. Selective labeling of kappa 2 opioid receptors in rat brain by [125I]IOXY: interaction of opioid peptides and other drugs with multiple kappa 2a binding sites. Ni, Q., Xu, H., Partilla, J.S., de Costa, B.R., Rice, K.C., Rothman, R.B. Peptides (1993) [Pubmed]
  11. Kappa opioid receptor-like immunoreactivity is present in substance P-containing subcortical afferents in guinea pig dentate gyrus. Drake, C.T., Chavkin, C., Milner, T.A. Hippocampus. (1997) [Pubmed]
  12. Inhibitory effect of spiradoline, a kappa opioid receptor agonist, on Ca2+ induced contraction and the intracellular Ca2+ concentration in porcine coronary artery. Harasawa, Y., Kimura, M., Hayashi, S. Cardiovasc. Res. (1991) [Pubmed]
  13. Kappa opioid receptor tolerance in the guinea pig hippocampus. Jin, W., Terman, G.W., Chavkin, C. J. Pharmacol. Exp. Ther. (1997) [Pubmed]
  14. Subsensitivity to opioids is receptor-specific in isolated guinea pig ileum and mouse vas deferens after obstructive cholestasis. Dehpour, A.R., Rastegar, H., Jorjani, M., Roushanzamir, F., Joharchi, K., Ahmadiani, A. J. Pharmacol. Exp. Ther. (2000) [Pubmed]
  15. Modulation of myofilament Ca2+ densitivity by delta- and kappa-opioid agonists in intact guinea pig hearts. Nakae, Y., Fujita, S., Namiki, A. Anesth. Analg. (2003) [Pubmed]
  16. Role of blood-brain barrier P-glycoprotein in limiting brain accumulation and sedative side-effects of asimadoline, a peripherally acting analgaesic drug. Jonker, J.W., Wagenaar, E., van Deemter, L., Gottschlich, R., Bender, H.M., Dasenbrock, J., Schinkel, A.H. Br. J. Pharmacol. (1999) [Pubmed]
  17. Structure-activity relationships for SNC80 and related compounds at cloned human delta and mu opioid receptors. Knapp, R.J., Santoro, G., De Leon, I.A., Lee, K.B., Edsall, S.A., Waite, S., Malatynska, E., Varga, E., Calderon, S.N., Rice, K.C., Rothman, R.B., Porreca, F., Roeske, W.R., Yamamura, H.I. J. Pharmacol. Exp. Ther. (1996) [Pubmed]
  18. Pharmacological properties of R-84760, a novel kappa-opioid receptor agonist. Fujibayashi, K., Sakamoto, K., Watanabe, M., Iizuka, Y. Eur. J. Pharmacol. (1994) [Pubmed]
  19. Design and synthesis of highly potent and selective cyclic dynorphin A analogues. Kawasaki, A.M., Knapp, R.J., Kramer, T.H., Wire, W.S., Vasquez, O.S., Yamamura, H.I., Burks, T.F., Hruby, V.J. J. Med. Chem. (1990) [Pubmed]
  20. Inhibitory effects of opioids on voltage-dependent Ca(2+) channels and catecholamine secretion in cultured porcine adrenal chromaffin cells. Kitamura, G., Ohta, T., Kai, T., Kon, Y., Ito, S. Brain Res. (2002) [Pubmed]
  21. Inhibition by nociceptin on excitatory non-adrenergic non-cholinergic response in guinea pig airways. Fang, L.B., Wu, Y., Zhang, L.F., Fang, W.Q. Acta Pharmacol. Sin. (2001) [Pubmed]
 
WikiGenes - Universities