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CYP2E1  -  cytochrome P450, family 2, subfamily E,...

Sus scrofa

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High impact information on CYP2E1


Biological context of CYP2E1


Anatomical context of CYP2E1

  • The results offer an explanation for the inhibition of CYP2E1 protein expression by androstenone in isolated pig hepatocytes and may be relevant to the low expression of hepatic CYP2E1 in those pigs which accumulate high levels of androstenone in vivo [7].
  • RESULTS: CYP2E1 was identified in the LLC-PK1 cells [8].
  • Excessive accumulation of skatole together with androstenone, a metabolite of testosterone, in adipose tissue in some pigs is a major cause of 'boar taint' and is associated with defective expression of CYP2E1 [9].
  • Diethyldithiocarbamate (DDC), a CYP2E1 inhibitor in humans, was a potent mechanism-based inhibitor of 6OH-CLZ formation in microsomes from all species examined [10].
  • A competitive inhibition of CYP2E1 by propofol was observed with low inhibition constants in the therapeutic range in both porcine (19 microM) and human (48 microM) liver microsomes [4].

Associations of CYP2E1 with chemical compounds


  1. Folate deficiency disturbs hepatic methionine metabolism and promotes liver injury in the ethanol-fed micropig. Halsted, C.H., Villanueva, J.A., Devlin, A.M., Niemelä, O., Parkkila, S., Garrow, T.A., Wallock, L.M., Shigenaga, M.K., Melnyk, S., James, S.J. Proc. Natl. Acad. Sci. U.S.A. (2002) [Pubmed]
  2. Induction of cytochrome P450 enzymes and generation of protein-aldehyde adducts are associated with sex-dependent sensitivity to alcohol-induced liver disease in micropigs. Niemelä, O., Parkkila, S., Pasanen, M., Viitala, K., Villanueva, J.A., Halsted, C.H. Hepatology (1999) [Pubmed]
  3. Chronic ethanol feeding and folate deficiency activate hepatic endoplasmic reticulum stress pathway in micropigs. Esfandiari, F., Villanueva, J.A., Wong, D.H., French, S.W., Halsted, C.H. Am. J. Physiol. Gastrointest. Liver Physiol. (2005) [Pubmed]
  4. Inhibition of cytochrome P450 2E1 by propofol in human and porcine liver microsomes. Lejus, C., Fautrel, A., Mallédant, Y., Guillouzo, A. Biochem. Pharmacol. (2002) [Pubmed]
  5. Cloning and mapping of the porcine cytochrome-p450 2E1 gene and its association with skatole levels in the domestic pig. Skinner, T.M., Doran, E., McGivan, J.D., Haley, C.S., Archibald, A.L. Anim. Genet. (2005) [Pubmed]
  6. Functional polymorphism in porcine CYP2E1 gene: Its association with skatole levels. Lin, Z., Lou, Y., Squires, E.J. J. Steroid Biochem. Mol. Biol. (2006) [Pubmed]
  7. The pig CYP2E1 promoter is activated by COUP-TF1 and HNF-1 and is inhibited by androstenone. Tambyrajah, W.S., Doran, E., Wood, J.D., McGivan, J.D. Arch. Biochem. Biophys. (2004) [Pubmed]
  8. Effect of cytochrome P450 2E1 inhibitors on cisplatin-induced cytotoxicity to renal proximal tubular epithelial cells. Liu, H., Baliga, M., Baliga, R. Anticancer Res. (2002) [Pubmed]
  9. Cytochrome P450IIE1 (CYP2E1) is induced by skatole and this induction is blocked by androstenone in isolated pig hepatocytes. Doran, E., Whittington, F.W., Wood, J.D., McGivan, J.D. Chem. Biol. Interact. (2002) [Pubmed]
  10. Biotransformation of chlorzoxazone by hepatic microsomes from humans and ten other mammalian species. Court, M.H., Von Moltke, L.L., Shader, R.I., Greenblatt, D.J. Biopharmaceutics & drug disposition. (1997) [Pubmed]
  11. Minipig cytochrome P450 2E1: comparison with human enzyme. Baranová, J., Anzenbacherová, E., Anzenbacher, P., Soucek, P. Drug Metab. Dispos. (2005) [Pubmed]
  12. Role of cytochrome P4502E1 activation in proximal tubular cell injury induced by hydrogen peroxide. Al-Ghamdi, S.S., Chatterjee, P.K., Raftery, M.J., Thiemermann, C., Yaqoob, M.M. Renal failure. (2004) [Pubmed]
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