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Gene Review

INSL3  -  insulin-like 3 (Leydig cell)

Canis lupus familiaris

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Disease relevance of INSL3


High impact information on INSL3


Anatomical context of INSL3


Associations of INSL3 with chemical compounds

  • Within the B-domain of canine RLF, the putative relaxin receptor binding motif contained a single substitution with the C-terminal arginine replaced by a serine residue, and the putative RLF receptor binding motif was truncated [1].

Analytical, diagnostic and therapeutic context of INSL3

  • RNA samples were reverse transcribed and analyzed by real-time PCR for the expression of canine relaxin receptor LRG7, relaxin, and RLF [2].


  1. Canine relaxin-like factor: unique molecular structure and differential expression within reproductive tissues of the dog. Klonisch, T., Kauffold, J., Steger, K., Bergmann, M., Leiser, R., Fischer, B., Hombach-Klonisch, S. Biol. Reprod. (2001) [Pubmed]
  2. Expression of relaxin receptor LRG7, canine relaxin, and relaxin-like factor in the pelvic diaphragm musculature of dogs with and without perineal hernia. Merchav, R., Feuermann, Y., Shamay, A., Ranen, E., Stein, U., Johnston, D.E., Shahar, R. Veterinary surgery : VS : the official journal of the American College of Veterinary Surgeons. (2005) [Pubmed]
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