Disease relevance of INSL3

• Leydig cells specifically expressed RLF in the normal postpubertal and cryptochid testis as well as in testicular Leydig cell adenoma [1].
• Expression of relaxin receptor LRG7, canine relaxin, and relaxin-like factor in the pelvic diaphragm musculature of dogs with and without perineal hernia [2].

High impact information on INSL3

• In the mature canine placenta, the trophoblast surrounding the maternal blood vessels and the hemophagous cytotrophoblast of the paraplacental zone expressed RLF [1].
• Canine relaxin-like factor: unique molecular structure and differential expression within reproductive tissues of the dog [1].
• Uteroplacental tissue at early stages of gestation revealed RLF expression in the proliferative fetal villous cytotrophoblast and in maternal uterine cells [1].
• The epididymis was an additional source of RLF in the dog [1].
• In the nonpregnant uterus, luminal and glandular epithelium coexpressed RLF and relaxin [1].

Anatomical context of INSL3

• Within the ovary, RLF, but not relaxin, was detected in follicular theca interna and granulosa cells and the corpus luteum [1].

Associations of INSL3 with chemical compounds

• Within the B-domain of canine RLF, the putative relaxin receptor binding motif contained a single substitution with the C-terminal arginine replaced by a serine residue, and the putative RLF receptor binding motif was truncated [1].

Analytical, diagnostic and therapeutic context of INSL3

• RNA samples were reverse transcribed and analyzed by real-time PCR for the expression of canine relaxin receptor LRG7, relaxin, and RLF [2].

References