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INSL3  -  insulin-like 3 (Leydig cell)

Bos taurus

 
 
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High impact information on INSL3

  • Dynamic changes in the expression of relaxin-like factor (INSL3), cholesterol side-chain cleavage cytochrome p450, and 3beta-hydroxysteroid dehydrogenase in bovine ovarian follicles during growth and atresia [1].
  • Not all follicles expressed pro-RLF in the theca interna, so the results are presented as the proportion of follicles expressing pro-RLF [1].
  • 3beta-Hydroxysteroid dehydrogenase was colocalized with pro-RLF (n = 86 follicles), and cholesterol side-chain cleavage cytochrome P450 was localized in another section of many of the same follicles (n = 66) [1].
  • As in the Leydig cells of the testis, the pattern of RLF gene expression appears to reflect the differentiation state of the ovarian theca-luteal cell lineage, and should prove useful for mapping the fate of these cells under differing stimulation regimes [2].
  • Addition of fetal calf serum to cultures caused a rapid and irreversible down-regulation of the RLF gene [2].
 

Biological context of INSL3

 

Anatomical context of INSL3

 

Associations of INSL3 with chemical compounds

References

  1. Dynamic changes in the expression of relaxin-like factor (INSL3), cholesterol side-chain cleavage cytochrome p450, and 3beta-hydroxysteroid dehydrogenase in bovine ovarian follicles during growth and atresia. Irving-Rodgers, H.F., Bathgate, R.A., Ivell, R., Domagalski, R., Rodgers, R.J. Biol. Reprod. (2002) [Pubmed]
  2. Expression and regulation of relaxin-like factor gene transcripts in the bovine ovary: differentiation-dependent expression in theca cell cultures. Bathgate, R., Moniac, N., Bartlick, B., Schumacher, M., Fields, M., Ivell, R. Biol. Reprod. (1999) [Pubmed]
  3. Differentiation-specific action of orphan nuclear receptor NR5A1 (SF-1): transcriptional regulation in luteinizing bovine theca cells. Walther, N., Jansen, M., Akbary, W., Ivell, R. Reprod. Biol. Endocrinol. (2006) [Pubmed]
  4. Relaxin-like factor (RLF) mRNA expression in the fallow deer. Hombach-Klonisch, S., Kauffold, J., Rautenberg, T., Steger, K., Tetens, F., Fischer, B., Klonisch, T. Mol. Cell. Endocrinol. (2000) [Pubmed]
  5. Adverse effects of environmental antiandrogens and androgens on reproductive development in mammals. Gray, L.E., Wilson, V.S., Stoker, T., Lambright, C., Furr, J., Noriega, N., Howdeshell, K., Ankley, G.T., Guillette, L. Int. J. Androl. (2006) [Pubmed]
 
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