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Gene Review

RLN1  -  relaxin 1

Canis lupus familiaris

Synonyms: RLN, RLN2
 
 
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Disease relevance of RLN2

  • Relaxin of prostatic origin might be linked to perineal hernia formation in dogs [1].
  • In two of the surviving animals, the ansa cervicalis was used to reinnervate the TA muscle, thereby preventing the possibility of reinnervation from the proximal RLN stump while limiting TA atrophy and fibrosis [2].
 

High impact information on RLN2

  • The concentrations of progesterone (P), relaxin (Rlx), estradiol (E2) and PRL were measured by specific RIAs in serum samples collected twice daily at 8:00 am and 3:00 pm at weekly intervals after mating and until whelping in five Labrador Retriever bitches [3].
  • Rlx bioactivity was detected in canine placentas and ovaries, providing supportive evidence that these organs may be a dual source of the hormone in canine pregnancy [3].
  • Within the ovary, RLF, but not relaxin, was detected in follicular theca interna and granulosa cells and the corpus luteum [4].
  • In the nonpregnant uterus, luminal and glandular epithelium coexpressed RLF and relaxin [4].
  • Within the B-domain of canine RLF, the putative relaxin receptor binding motif contained a single substitution with the C-terminal arginine replaced by a serine residue, and the putative RLF receptor binding motif was truncated [4].
 

Biological context of RLN2

 

Anatomical context of RLN2

 

Associations of RLN2 with chemical compounds

 

Regulatory relationships of RLN2

 

Other interactions of RLN2

 

Analytical, diagnostic and therapeutic context of RLN2

References

  1. Relaxin of prostatic origin might be linked to perineal hernia formation in dogs. Niebauer, G.W., Shibly, S., Seltenhammer, M., Pirker, A., Brandt, S. Ann. N. Y. Acad. Sci. (2005) [Pubmed]
  2. Bilateral thyroarytenoid denervation: a new treatment for laryngeal hyperadduction disorders studied in the canine. Sercarz, J.A., Berke, G.S., Ming, Y., Rothschiller, J., Graves, M.C. Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery. (1992) [Pubmed]
  3. Diurnal variation of serum progesterone, but not relaxin, prolactin, or estradiol-17 beta in the pregnant bitch. Steinetz, B.G., Goldsmith, L.T., Hasan, S.H., Lust, G. Endocrinology (1990) [Pubmed]
  4. Canine relaxin-like factor: unique molecular structure and differential expression within reproductive tissues of the dog. Klonisch, T., Kauffold, J., Steger, K., Bergmann, M., Leiser, R., Fischer, B., Hombach-Klonisch, S. Biol. Reprod. (2001) [Pubmed]
  5. Canine preprorelaxin: nucleic acid sequence and localization within the canine placenta. Klonisch, T., Hombach-Klonisch, S., Froehlich, C., Kauffold, J., Steger, K., Steinetz, B.G., Fischer, B. Biol. Reprod. (1999) [Pubmed]
  6. Plasma relaxin levels in pregnant and lactating dogs. Steinetz, B.G., Goldsmith, L.T., Lust, G. Biol. Reprod. (1987) [Pubmed]
  7. Serum relaxin and progesterone concentrations in pregnant, pseudopregnant, and ovariectomized, progestin-treated pregnant bitches: detection of relaxin as a marker of pregnancy. Steinetz, B.G., Goldsmith, L.T., Harvey, H.J., Lust, G. Am. J. Vet. Res. (1989) [Pubmed]
  8. Concentrations of progesterone, prolactin and relaxin in the luteal phase and pregnancy in normal and short-cycling German Shepherd dogs. Günzel-Apel, A.R., Zabel, S., Bunck, C.F., Dieleman, S.J., Einspanier, A., Hoppen, H.O. Theriogenology (2006) [Pubmed]
  9. Purification and sequence determination of canine relaxin. Stewart, D.R., Henzel, W.J., Vandlen, R. J. Protein Chem. (1992) [Pubmed]
  10. Embryo development, hormonal requirements and maternal responses during canine pregnancy. Concannon, P., Tsutsui, T., Shille, V. J. Reprod. Fertil. Suppl. (2001) [Pubmed]
  11. Expression of relaxin receptor LRG7, canine relaxin, and relaxin-like factor in the pelvic diaphragm musculature of dogs with and without perineal hernia. Merchav, R., Feuermann, Y., Shamay, A., Ranen, E., Stein, U., Johnston, D.E., Shahar, R. Veterinary surgery : VS : the official journal of the American College of Veterinary Surgeons. (2005) [Pubmed]
  12. Use of relaxin in orthodontics. Stewart, D.R., Sherick, P., Kramer, S., Breining, P. Ann. N. Y. Acad. Sci. (2005) [Pubmed]
 
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