Gene Review:
INSL3 - insulin-like 3 (Leydig cell)
Homo sapiens
Synonyms:
Insulin-like 3, Ley-I-L, Leydig insulin-like peptide, MGC119818, MGC119819, ...
Wikström,
Bay,
Hero,
Andersson,
Dunkel,
Ivell,
Hartung,
Klonisch,
Mustafa,
Bialek,
Radestock,
Holzhausen,
Dralle,
Hoang-Vu,
Hombach-Klonisch,
Bay,
Hartung,
Ivell,
Schumacher,
Jürgensen,
Jorgensen,
Holm,
Skakkebaek,
Andersson,
Ivell,
Bathgate,
Klonisch,
Müller-Huesmann,
Riedel,
Kehlen,
Bialek,
Radestock,
Holzhausen,
Steger,
Ludwig,
Weidner,
Hoang-Vu,
Hombach-Klonisch,
Hombach-Klonisch,
Schön,
Kehlen,
Blottner,
Klonisch,
Foresta,
Bettella,
Vinanzi,
Dabrilli,
Meriggiola,
Garolla,
Ferlin,
Klonisch,
Steger,
Kehlen,
Allen,
Froehlich,
Kauffold,
Bergmann,
Hombach-Klonisch,
Foster,
- Insulin-like 3/relaxin-like factor gene mutations are associated with cryptorchidism. Tomboc, M., Lee, P.A., Mitwally, M.F., Schneck, F.X., Bellinger, M., Witchel, S.F. J. Clin. Endocrinol. Metab. (2000)
- A novel circulating hormone of testis origin in humans. Foresta, C., Bettella, A., Vinanzi, C., Dabrilli, P., Meriggiola, M.C., Garolla, A., Ferlin, A. J. Clin. Endocrinol. Metab. (2004)
- INSL3 in the benign hyperplastic and neoplastic human prostate gland. Klonisch, T., Müller-Huesmann, H., Riedel, M., Kehlen, A., Bialek, J., Radestock, Y., Holzhausen, H.J., Steger, K., Ludwig, M., Weidner, W., Hoang-Vu, C., Hombach-Klonisch, S. Int. J. Oncol. (2005)
- Insulin-like factor 3 gene mutations in testicular dysgenesis syndrome: clinical and functional characterization. Ferlin, A., Bogatcheva, N.V., Gianesello, L., Pepe, A., Vinanzi, C., Agoulnik, A.I., Foresta, C. Mol. Hum. Reprod. (2006)
- INSL-3 is expressed in human hyperplastic and neoplastic thyrocytes. Hombach-Klonisch, S., Hoang-Vu, C., Kehlen, A., Hinze, R., Holzhausen, H.J., Weber, E., Fischer, B., Dralle, H., Klonisch, T. Int. J. Oncol. (2003)
- The mode of interaction of the relaxin-like factor (RLF) with the leucine-rich repeat G protein-activated receptor 8. Büllesbach, E.E., Schwabe, C. J. Biol. Chem. (2006)
- Solution Structure and Characterization of the LGR8 Receptor Binding Surface of Insulin-like Peptide 3. Rosengren, K.J., Zhang, S., Lin, F., Daly, N.L., Scott, D.J., Hughes, R.A., Bathgate, R.A., Craik, D.J., Wade, J.D. J. Biol. Chem. (2006)
- Serum Insulin-Like Factor 3 Levels during Puberty in Healthy Boys and Boys with Klinefelter Syndrome. Wikstr??m, A.M., Bay, K., Hero, M., Andersson, A.M., Dunkel, L. J. Clin. Endocrinol. Metab. (2006)
- Reproductive biology of the relaxin-like factor (RLF/INSL3). Ivell, R., Bathgate, R.A. Biol. Reprod. (2002)
- Disruption of reproductive development in male rat offspring following in utero exposure to phthalate esters. Foster, P.M. Int. J. Androl. (2006)
- T222P mutation of the insulin-like 3 hormone receptor LGR8 is associated with testicular maldescent and hinders receptor expression on the cell surface membrane. Bogatcheva, N.V., Ferlin, A., Feng, S., Truong, A., Gianesello, L., Foresta, C., Agoulnik, A.I. Am. J. Physiol. Endocrinol. Metab. (2007)
- The molecular basis of cryptorchidism. Ivell, R., Hartung, S. Mol. Hum. Reprod. (2003)
- INSL3/Leydig insulin-like peptide activates the LGR8 receptor important in testis descent. Kumagai, J., Hsu, S.Y., Matsumi, H., Roh, J.S., Fu, P., Wade, J.D., Bathgate, R.A., Hsueh, A.J. J. Biol. Chem. (2002)
- Structural requirements for the interaction of sheep insulin-like factor 3 with relaxin receptors in rat atria. Tan, Y.Y., Dawson, N.F., Kompa, A.R., Bond, C.P., Claasz, A., Wade, J.D., Tregear, G.W., Summers, R.J. Eur. J. Pharmacol. (2002)
- Relaxin research in the postgenomic era. Kawamura, K., Sudo, S., Kumagai, J., Pisarska, M., Hsu, S.Y., Bathgate, R., Wade, J., Hsueh, A.J. Ann. N. Y. Acad. Sci. (2005)
- Human medullary thyroid carcinoma: a source and potential target for relaxin-like hormones. Klonisch, T., Mustafa, T., Bialek, J., Radestock, Y., Holzhausen, H.J., Dralle, H., Hoang-Vu, C., Hombach-Klonisch, S. Ann. N. Y. Acad. Sci. (2005)
- Mutation analysis of INSL3 and GREAT/LGR8 genes in familial cryptorchidism. Feng, S., Cortessis, V.K., Hwang, A., Hardy, B., Koh, C.J., Bogatcheva, N.V., Agoulnik, A.I. Urology (2004)
- The human Leydig insulin-like (hLEY I-L) gene is expressed in the corpus luteum and trophoblast. Tashima, L.S., Hieber, A.D., Greenwood, F.C., Bryant-Greenwood, G.D. J. Clin. Endocrinol. Metab. (1995)
- Seasonal expression of INSL3 and Lgr8/Insl3 receptor transcripts indicates variable differentiation of Leydig cells in the roe deer testis. Hombach-Klonisch, S., Schön, J., Kehlen, A., Blottner, S., Klonisch, T. Biol. Reprod. (2004)
- Insulin-like factor 3 serum levels in 135 normal men and 85 men with testicular disorders: relationship to the luteinizing hormone-testosterone axis. Bay, K., Hartung, S., Ivell, R., Schumacher, M., Jürgensen, D., Jorgensen, N., Holm, M., Skakkebaek, N.E., Andersson, A.M. J. Clin. Endocrinol. Metab. (2005)
- INSL3 ligand-receptor system in the equine testis. Klonisch, T., Steger, K., Kehlen, A., Allen, W.R., Froehlich, C., Kauffold, J., Bergmann, M., Hombach-Klonisch, S. Biol. Reprod. (2003)