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LPL  -  lipoprotein lipase

Canis lupus familiaris

 
 
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Disease relevance of LPL

  • NPX dogs had fasting hypertriglyceridemia (82 + 6.0 mg/dl vs. 49 +/- 2.7 mg/dl in normal dogs, P less than 0.01), abnormal IVFTT, and reduced post-heparin plasma LPL activity (151 +/- 10 vs. 275 +/- 15 mumol fatty acids/ml/min in normal dogs, P less than 0.01) [1].
  • After 60 min of myocardial ischemia a significantly lower LPL activity was found in full wall biopsies of ischemic than of non-ischemic left ventricular myocardium [2].
  • Changes in pulmonary lipoprotein lipase activity in dogs following experimental bone fracture. A new concept on the pathogenesis of post-traumatic impairment of lung surfactant synthesis and accumulation of fat in lung vessels [3]?
  • Thus it appears that FFA release secondary to the action of pulmonary lipoprotein lipase on blood triglyceride is the important pathogenic step in the induction of respiratory failure in this model [4].
  • A novel compound, NO-1886, which possesses a powerful lipoprotein lipase activity-increasing action, induces hypertrophy of adrenals in rats and hyperplasia of cortical cells in dogs [5].
 

High impact information on LPL

  • Specific LPL binding was eliminated by incubating the BAEC at 4 degrees C with heparin containing buffer prior to the addition of LPL [6].
  • Recent data from our laboratory (Sivaram et al. 1992. J. Biol. Chem. 267: 16517-16522) have shown that a heparin-sensitive, non-proteoglycan 116-kDa LPL-binding protein is present on cultured bovine aortic endothelial cells (BAEC) [6].
  • Furthermore, when LPL interaction with the 116-kDa binding protein was studied using ligand blots, 125I-labeled LPL binding was blocked only by unlabeled LPL.(ABSTRACT TRUNCATED AT 250 WORDS)[6]
  • The data are consistent with the notion that excess PTH reduces post-heparin LPL activity in plasma, which in turn results in impaired lipid removal from the circulation and consequently hyperlipidemia [1].
  • The storage and synthetic pools of heparin-releasable lipoprotein lipase and hepatic triacylglycerol lipase in the growing puppy [7].
 

Chemical compound and disease context of LPL

  • On the other hand, the simultaneous infusion of 0.5 gram of fat and 8 U.S.P. units of heparin per kilogram of body weight per hour released more lipoprotein lipase than the fat emulsion alone [8].
 

Biological context of LPL

 

Anatomical context of LPL

  • Existence of two forms of LPL: heparin releasable and unreleasable was demonstrated in skeletal muscles, and the changes in the activity of both forms were followed during 3 h treadmill running, using biopsy samples taken from m. biceps femoris [10].
  • The ischemia-induced reduction in LPL activity was most pronounced in the endocardial half of the myocardium [2].
  • In conclusion: it was found that physical exercise induces a marked intensity-dependent increase of LPL activity in working muscles, which is probably caused by an elevated transport of the enzyme molecules from the muscle cells to the intravascular space [10].
  • Changes in lipoprotein lipase activity /LPLA/ in the quadriceps femoris muscle were followed in ten dogs during 3-hour treadmill exercise and 2-hour post-exercise recovery period [11].
  • Cell-free translation of avian adipose tissue lipoprotein lipase messenger RNA [12].
 

Associations of LPL with chemical compounds

 

Other interactions of LPL

 

Analytical, diagnostic and therapeutic context of LPL

References

  1. Excess parathyroid hormone adversely affects lipid metabolism in chronic renal failure. Akmal, M., Kasim, S.E., Soliman, A.R., Massry, S.G. Kidney Int. (1990) [Pubmed]
  2. Myocardial lipoproteins lipase activity during acute myocardial ischemia in dogs. Vik-Mo, H., Moen, P., Mjøs, O.D. Horm. Metab. Res. (1982) [Pubmed]
  3. Changes in pulmonary lipoprotein lipase activity in dogs following experimental bone fracture. A new concept on the pathogenesis of post-traumatic impairment of lung surfactant synthesis and accumulation of fat in lung vessels? Lehr, L., Niedermüller, H., Hofecker, G. Surgery (1977) [Pubmed]
  4. Respiratory failure in acute pancreatitis: the role of free fatty acids. Kimura, T., Toung, J.K., Margolis, S., Bell, W.R., Cameron, J.L. Surgery (1980) [Pubmed]
  5. Lipoprotein lipase promoting agent, NO-1886, modulates adrenal functions: species difference in effects of NO-1886 on steroidogenesis. Shimono, K., Tsutsumi, K., Yaguchi, H., Omura, M., Sasano, H., Nishikawa, T. Steroids (1999) [Pubmed]
  6. Specificity of lipoprotein lipase binding to endothelial cells. Stins, M.F., Sivaram, P., Sasaki, A., Goldberg, I.J. J. Lipid Res. (1993) [Pubmed]
  7. The storage and synthetic pools of heparin-releasable lipoprotein lipase and hepatic triacylglycerol lipase in the growing puppy. Das, J.B., Joshi, I.D., Philippart, A.I. Biochem. J. (1982) [Pubmed]
  8. Effect of single infusion of fat emulsion on plasma lipid. Koga, Y., Ikeda, K., Inokuchi, K. Surgery, gynecology & obstetrics. (1975) [Pubmed]
  9. Postnatal development of lipid-clearing enzymes in the suckling animal. Das, J.B., Joshi, I.D., Philippart, A.I. J. Pediatr. Surg. (1982) [Pubmed]
  10. Exercise-induced changes in lipoprotein lipase activity (LPLA) in skeletal muscles of the dog. Budohoski, L. Pflugers Arch. (1985) [Pubmed]
  11. Lipoprotein lipase activity in the skeletal muscle during physical exercise in dogs. Kozłowski, S., Budohoski, L., Pohoska, E., Nazar, K. Pflugers Arch. (1979) [Pubmed]
  12. Cell-free translation of avian adipose tissue lipoprotein lipase messenger RNA. Strieleman, P.J., Bensadoun, A. Biochim. Biophys. Acta (1987) [Pubmed]
  13. Transformation of Ob17 cells promotes proliferation and differentiation of Ob17 preadipocytes via distinct extracellular intermediates. Czerucka, D., Grimaldi, P., Ailhaud, G. Biochem. Biophys. Res. Commun. (1986) [Pubmed]
  14. "Lipolipin": a glycoprotein inhibitor of postheparin plasma lipoprotein lipase. Wagh, P.V. Adv. Exp. Med. Biol. (1975) [Pubmed]
  15. Molecular evidence supporting the portal theory: a causative link between visceral adiposity and hepatic insulin resistance. Kabir, M., Catalano, K.J., Ananthnarayan, S., Kim, S.P., Van Citters, G.W., Dea, M.K., Bergman, R.N. Am. J. Physiol. Endocrinol. Metab. (2005) [Pubmed]
  16. Use of oral and intravenous fat tolerance tests to assess plasma chylomicron clearance in dogs. Watson, T.D., Mackenzie, J.A., Stewart, J.P., Barrie, J. Res. Vet. Sci. (1995) [Pubmed]
 
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