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CLCN1  -  chloride channel, voltage-sensitive 1

Canis lupus familiaris

 
 
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Disease relevance of CLCN1

 

High impact information on CLCN1

 

Biological context of CLCN1

 

Anatomical context of CLCN1

 

Associations of CLCN1 with chemical compounds

 

Other interactions of CLCN1

 

Analytical, diagnostic and therapeutic context of CLCN1

  • In particular, a potassium and a chloride channel appeared in the recordings more frequently than other channels, and this allowed a more detailed study of their properties in the inside-out configuration of the patch-clamp technique [15].
  • RESULTS: Enzyme digestion of PCR products of the normal CIC-1 allele resulted in 3 fragments of 175, 135, and 30 bp, whereas PCR products of the mutant allele resulted in fragments of only 175 and 165 bp [2].

References

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  2. Detection of a genetic mutation for myotonia congenita among Miniature Schnauzers and identification of a common carrier ancestor. Bhalerao, D.P., Rajpurohit, Y., Vite, C.H., Giger, U. Am. J. Vet. Res. (2002) [Pubmed]
  3. CFTR Cl- channel and CFTR-associated ATP channel: distinct pores regulated by common gates. Sugita, M., Yue, Y., Foskett, J.K. EMBO J. (1998) [Pubmed]
  4. Inhibition of iodide transport in thyroid cells by dysidenin, a marine toxin, and some of its analogs. Van Sande, J., Deneubourg, F., Beauwens, R., Braekman, J.C., Daloze, D., Dumont, J.E. Mol. Pharmacol. (1990) [Pubmed]
  5. Specialised pacemaking cells in the rabbit urethra. Sergeant, G.P., Hollywood, M.A., McCloskey, K.D., Thornbury, K.D., McHale, N.G. J. Physiol. (Lond.) (2000) [Pubmed]
  6. Functional and molecular expression of volume-regulated chloride channels in canine vascular smooth muscle cells. Yamazaki, J., Duan, D., Janiak, R., Kuenzli, K., Horowitz, B., Hume, J.R. J. Physiol. (Lond.) (1998) [Pubmed]
  7. A missense mutation in canine C1C-1 causes recessive myotonia congenita in the dog. Rhodes, T.H., Vite, C.H., Giger, U., Patterson, D.F., Fahlke, C., George, A.L. FEBS Lett. (1999) [Pubmed]
  8. I(to) and action potential notch are smaller in left vs. right canine ventricular epicardium. Di Diego, J.M., Sun, Z.Q., Antzelevitch, C. Am. J. Physiol. (1996) [Pubmed]
  9. Cytoprotection of kidney epithelial cells by compounds that target amino acid gated chloride channels. Venkatachalam, M.A., Weinberg, J.M., Patel, Y., Saikumar, P., Dong, Z. Kidney Int. (1996) [Pubmed]
  10. An inwardly rectifying chloride channel in ragweed-sensitized canine tracheal epithelial cells. Duszyk, M., French, A.S., Man, S.F., Becker, A.B. Eur. Biophys. J. (1991) [Pubmed]
  11. Actions of putative chloride channel blocking agents on canine lower esophageal sphincter (LES). Jury, J., Patel, M., Bowes, T., Daniel, E.E. Can. J. Physiol. Pharmacol. (2001) [Pubmed]
  12. Cardiac swelling-induced chloride current depolarizes canine atrial myocytes. Du, X.Y., Sorota, S. Am. J. Physiol. (1997) [Pubmed]
  13. Activation of chloride conductance induced by potassium in tracheal epithelium. Stutts, M.J., Gatzy, J.T., Boucher, R.C. Pflugers Arch. (1988) [Pubmed]
  14. Proton gradient formation in early endosomes from proximal tubules. Marshansky, V., Vinay, P. Biochim. Biophys. Acta (1996) [Pubmed]
  15. Activation of K+ and Cl- channels in MDCK cells during volume regulation in hypotonic media. Banderali, U., Roy, G. J. Membr. Biol. (1992) [Pubmed]
 
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