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Gene Review

ACTG1  -  actin, gamma 1

Canis lupus familiaris

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Disease relevance of LOC442937


High impact information on LOC442937

  • Although the proportion of beta-actin was unchanged, the proportion of alpha-actin in the gallbladder was less in the animals fed the high-cholesterol diet (32.6% +/- 1.5% in the control animals and 24.6% +/- 0.4% in the diet animals) [4].
  • Relative to both MDCK and MSV-MDCK cells, the MSV-MDCK-INV cells exhibit increased expression of beta-actin and redistribution of beta-actin to the tips of pseudopodia [1].
  • Our results indicate that acid secretagogue-specific receptor activation in parietal cells triggers coordinate gene expression of the two enzymes involved in H+ ion generation and that beta-actin may be an important regulator of acid secretion [5].
  • Furthermore, pronounced increases, with different kinetics, in expression of beta-actin mRNA were observed [5].
  • With increasing time after cell isolation, carbonic anhydrase II and H+,K+-ATPase, but not beta-actin, mRNA levels were attenuated, suggesting that parietal cell-specific genes may be dependent upon maintenance of parietal cell contacts within intact mucosal tissue [5].

Biological context of LOC442937


Anatomical context of LOC442937


Associations of LOC442937 with chemical compounds


Other interactions of LOC442937


Analytical, diagnostic and therapeutic context of LOC442937

  • In contrast, mean nitric oxide synthase/beta-actin in the medulla of the obstructed kidney was 1.29 +/- 0.33 densitometry units, greater than the 0.34 +/- 0.03 densitometry units in the unobstructed kidney (p <0.05) [14].
  • Furthermore, both staining and immunoblotting showed markedly increased beta-actin protein in myocardium within 24 h of either regional left ventricular damage or chronic volume overload [8].
  • Beta-actin mRNA expression and structural change of its 3' untranslated region (UTR) which are considered a non-specific marker for vascular remodeling, were examined by Northern analysis and polymerase chain reaction analysis in a canine basilar artery after experimental SAH [3].


  1. Increased beta-actin expression in an invasive moloney sarcoma virus-transformed MDCK cell variant concentrates to the tips of multiple pseudopodia. Le, P.U., Nguyen, T.N., Drolet-Savoie, P., Leclerc, N., Nabi, I.R. Cancer Res. (1998) [Pubmed]
  2. Autocrine activation of the hepatocyte growth factor receptor/met tyrosine kinase induces tumor cell motility by regulating pseudopodial protrusion. Vadnais, J., Nault, G., Daher, Z., Amraei, M., Dodier, Y., Nabi, I.R., Noël, J. J. Biol. Chem. (2002) [Pubmed]
  3. Changes of beta-actin mRNA expression in canine vasospastic basilar artery after experimental subarachnoid hemorrhage. Ohkuma, H., Tsurutani, H., Suzuki, S. Neurosci. Lett. (2001) [Pubmed]
  4. Actin and myosin isoforms in gallbladder smooth muscle following cholesterol feeding in prairie dogs. Li, Y.F., Bowers, R.L., Haley-Russell, D., Moody, F.G., Weisbrodt, N.W. Gastroenterology (1990) [Pubmed]
  5. Acid secretagogue-induced stimulation of gastric parietal cell gene expression. Campbell, V.W., Yamada, T. J. Biol. Chem. (1989) [Pubmed]
  6. Purification and characterization of beta-actin-rich tumor cell pseudopodia: role of glycolysis. Nguyen, T.N., Wang, H.J., Zalzal, S., Nanci, A., Nabi, I.R. Exp. Cell Res. (2000) [Pubmed]
  7. Increased expression of endoarterial vascular cell adhesion molecule-1 mRNA in an experimental model of lung transplant rejection: diagnosis by pulmonary arterial biopsy. Rothman, A., Mann, D., Behling, C.A., McGraw, M., Seslar, S., Shiu, P., Zhang, L., Kriett, J.M. Transplantation (2003) [Pubmed]
  8. Localization of changes in beta-actin expression in remodeled canine myocardium. Tian, B., Carlyle, W.C., Weigold, W.G., McDonald, K.M., Judd, D.L., Toher, C.A., Homans, D.C., Cohn, J.N. J. Mol. Cell. Cardiol. (1999) [Pubmed]
  9. Nuclear receptor and nuclear receptor target gene messenger ribonucleic acid levels at different sites of the gastrointestinal tract and in liver of healthy dogs. Gropp, F.N., Greger, D.L., Morel, C., Sauter, S., Blum, J.W. J. Anim. Sci. (2006) [Pubmed]
  10. Functional and molecular expression of volume-regulated chloride channels in canine vascular smooth muscle cells. Yamazaki, J., Duan, D., Janiak, R., Kuenzli, K., Horowitz, B., Hume, J.R. J. Physiol. (Lond.) (1998) [Pubmed]
  11. Effect of omeprazole on gene expression in canine gastric parietal cells. Campbell, V.W., Yamada, T. Am. J. Physiol. (1991) [Pubmed]
  12. Rho/ROCK-dependent pseudopodial protrusion and cellular blebbing are regulated by p38 MAPK in tumour cells exhibiting autocrine c-Met activation. Jia, Z., Vadnais, J., Lu, M.L., Noël, J., Nabi, I.R. Biol. Cell (2006) [Pubmed]
  13. RT-PCR amplification of various canine cytokines and so-called house-keeping genes in a species-specific macrophage cell line (DH82) and canine peripheral blood leukocytes. Gröne, A., Fonfara, S., Markus, S., Baumgärtner, W. Zentralblatt Veterinarmedizin Reihe B (1999) [Pubmed]
  14. Regional expression of inducible nitric oxide synthase in the kidney in dogs with unilateral ureteral obstruction. Fitzgerald, J., Chou, S.Y., Wahid, A., Porush, J.G. J. Urol. (2001) [Pubmed]
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