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Gene Review

CDH3  -  cadherin 3, type 1, P-cadherin (placental)

Gallus gallus

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High impact information on K-CAM

  • Chick B-cadherin and murine E-cadherin also form mixed aggregates, indistinguishable from homophilic aggregates [1].
  • B-cadherin- and LCAM-expressing cell lines, however, appear to be completely miscible, forming large mixed aggregates [1].
  • To examine the possibility that they might bind to one another in a heterophilic manner, we generated, by cDNA transfection, L-cell lines that express LCAM or B-cadherin [1].
  • These results suggest that B-cadherin has important functions in neurogenesis, in at least some epithelia, and in embryogenesis [2].
  • In particular, immunohistochemical staining and in situ hybridization localize B-cadherin protein and mRNA to the epithelial lining of the choroid plexus and to cells in specific layers of the optic tectum in chick brain [2].

Biological context of K-CAM

  • As has been observed for other cadherins, B-cadherin, when expressed in mouse L929 fibroblasts, confers upon them a calcium-dependent cell aggregation activity [3].
  • CONCLUSIONS; These results suggest that while both N- and B-cadherin are expressed during lens cell differentiation, both their patterns of expression as well as their cytoskeletal association differ between epithelial and fiber cells [4].
  • PURPOSE: To analyze the dynamics of N- and B-cadherin cell adhesion molecule expression and cytoskeletal interaction during embryonic chick lens development [4].

Anatomical context of K-CAM


Other interactions of K-CAM


Analytical, diagnostic and therapeutic context of K-CAM


  1. The cadherin-binding specificities of B-cadherin and LCAM. Murphy-Erdosh, C., Yoshida, C.K., Paradies, N., Reichardt, L.F. J. Cell Biol. (1995) [Pubmed]
  2. Molecular cloning and characterization of B-cadherin, a novel chick cadherin. Napolitano, E.W., Venstrom, K., Wheeler, E.F., Reichardt, L.F. J. Cell Biol. (1991) [Pubmed]
  3. The expression of B-cadherin during embryonic chick development. Murphy-Erdosh, C., Napolitano, E.W., Reichardt, L.F. Dev. Biol. (1994) [Pubmed]
  4. Differential expression of N- and B-cadherin during lens development. Leong, L., Menko, A.S., Grunwald, G.B. Invest. Ophthalmol. Vis. Sci. (2000) [Pubmed]
  5. R- and B-cadherin expression defines subpopulations of glial cells involved in axonal guidance in the optic nerve head of the chicken. Gerhardt, H., Rascher, G., Schuck, J., Weigold, U., Redies, C., Wolburg, H. Glia (2000) [Pubmed]
  6. Genes for two calcium-dependent cell adhesion molecules have similar structures and are arranged in tandem in the chicken genome. Sorkin, B.C., Gallin, W.J., Edelman, G.M., Cunningham, B.A. Proc. Natl. Acad. Sci. U.S.A. (1991) [Pubmed]
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