The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)



Gene Review

Cdh3  -  cadherin 3

Mus musculus

Synonyms: AI385538, Cadherin-3, Cadp, Cdhp, P-cadherin, ...
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of Cdh3


High impact information on Cdh3

  • E- or P-cadherin was transfected into L cells, which normally have little cadherin activity, and cellular aggregation of the resulting transfectants was observed to be a function of the cadherin molecule expressed [6].
  • The interaction between nephrin and Neph1 is specific and not shared by either protein with P-cadherin, another integral slit diaphragm protein [7].
  • BC44 mammary epithelial cells in culture, display phenotypic characteristics of basal epithelium, i.e., express basal cytokeratins 5 and 14 and P-cadherin, but no smooth muscle markers [8].
  • In contrast to E- and N-cadherin- deficient mice, mice homozygous for the P-cadherin mutation are viable [4].
  • Furthermore, the loss of P-cadherin from the myoepithelium has uncovered a novel function for this tissue in maintaining the undifferentiated state of the underlying secretory epithelium [4].

Biological context of Cdh3


Anatomical context of Cdh3


Associations of Cdh3 with chemical compounds


Regulatory relationships of Cdh3


Other interactions of Cdh3


Analytical, diagnostic and therapeutic context of Cdh3


  1. Postnatal lethality of P-cadherin/desmoglein 3 double knockout mice: demonstration of a cooperative effect of these cell adhesion molecules in tissue homeostasis of stratified squamous epithelia. Lenox, J.M., Koch, P.J., Mahoney, M.G., Lieberman, M., Stanley, J.R., Radice, G.L. J. Invest. Dermatol. (2000) [Pubmed]
  2. The generation and in vivo differentiation of murine embryonal stem cells genetically null for either N-cadherin or N- and P-cadherin. Moore, R., Radice, G.L., Dominis, M., Kemler, R. Int. J. Dev. Biol. (1999) [Pubmed]
  3. A role for the E-cadherin cell-cell adhesion molecule during tumor progression of mouse epidermal carcinogenesis. Navarro, P., Gómez, M., Pizarro, A., Gamallo, C., Quintanilla, M., Cano, A. J. Cell Biol. (1991) [Pubmed]
  4. Precocious mammary gland development in P-cadherin-deficient mice. Radice, G.L., Ferreira-Cornwell, M.C., Robinson, S.D., Rayburn, H., Chodosh, L.A., Takeichi, M., Hynes, R.O. J. Cell Biol. (1997) [Pubmed]
  5. Expression pattern of the cell adhesion molecules. E-cadherin, P-cadherin and alpha 6 beta 4 intergrin is altered in pre-malignant skin tumors of p53-deficient mice. Cano, A., Gamallo, C., Kemp, C.J., Benito, N., Palacios, J., Quintanilla, M., Balmain, A. Int. J. Cancer (1996) [Pubmed]
  6. Expressed recombinant cadherins mediate cell sorting in model systems. Nose, A., Nagafuchi, A., Takeichi, M. Cell (1988) [Pubmed]
  7. Neph1 and nephrin interaction in the slit diaphragm is an important determinant of glomerular permeability. Liu, G., Kaw, B., Kurfis, J., Rahmanuddin, S., Kanwar, Y.S., Chugh, S.S. J. Clin. Invest. (2003) [Pubmed]
  8. EGF controls the in vivo developmental potential of a mammary epithelial cell line possessing progenitor properties. Deugnier, M.A., Faraldo, M.M., Janji, B., Rousselle, P., Thiery, J.P., Glukhova, M.A. J. Cell Biol. (2002) [Pubmed]
  9. Isolation of placental cadherin cDNA: identification of a novel gene family of cell-cell adhesion molecules. Nose, A., Nagafuchi, A., Takeichi, M. EMBO J. (1987) [Pubmed]
  10. Expression and role of E- and P-cadherin adhesion molecules in embryonic histogenesis. I. Lung epithelial morphogenesis. Hirai, Y., Nose, A., Kobayashi, S., Takeichi, M. Development (1989) [Pubmed]
  11. Subcellular localization of beta-catenin and cadherin expression in the cap-stage enamel organ of the mouse molar. Obara, N., Lesot, H. Histochem. Cell Biol. (2004) [Pubmed]
  12. E- and P-cadherin expression during murine hair follicle morphogenesis and cycling. Müller-Röver, S., Tokura, Y., Welker, P., Furukawa, F., Wakita, H., Takigawa, M., Paus, R. Exp. Dermatol. (1999) [Pubmed]
  13. Genomic organization and chromosomal mapping of the mouse P-cadherin gene. Hatta, M., Miyatani, S., Copeland, N.G., Gilbert, D.J., Jenkins, N.A., Takeichi, M. Nucleic Acids Res. (1991) [Pubmed]
  14. A novel cadherin cell adhesion molecule: its expression patterns associated with implantation and organogenesis of mouse embryos. Nose, A., Takeichi, M. J. Cell Biol. (1986) [Pubmed]
  15. Expression and role of E- and P-cadherin adhesion molecules in embryonic histogenesis. II. Skin morphogenesis. Hirai, Y., Nose, A., Kobayashi, S., Takeichi, M. Development (1989) [Pubmed]
  16. Cell-extracellular matrix interactions and EGF are important regulators of the basal mammary epithelial cell phenotype. Deugnier, M.A., Faraldo, M.M., Rousselle, P., Thiery, J.P., Glukhova, M.A. J. Cell. Sci. (1999) [Pubmed]
  17. P-Cadherin is decreased in diabetic glomeruli and in glucose-stimulated podocytes in vivo and in vitro studies. Xu, Z.G., Ryu, D.R., Yoo, T.H., Jung, D.S., Kim, J.J., Kim, H.J., Choi, H.Y., Kim, J.S., Adler, S.G., Natarajan, R., Han, D.S., Kang, S.W. Nephrol. Dial. Transplant. (2005) [Pubmed]
  18. Systematic analysis of E-, N- and P-cadherin expression in mouse eye development. Xu, L., Overbeek, P.A., Reneker, L.W. Exp. Eye Res. (2002) [Pubmed]
  19. Expression of E- and P-cadherin during tooth morphogenesis and cytodifferentiation of ameloblasts. Obara, N., Suzuki, Y., Nagai, Y., Takeda, M. Anat. Embryol. (1998) [Pubmed]
  20. Differential expression and function of cadherin-6 during renal epithelium development. Cho, E.A., Patterson, L.T., Brookhiser, W.T., Mah, S., Kintner, C., Dressler, G.R. Development (1998) [Pubmed]
  21. Thyroid hormone down-regulates neural cell adhesion molecule expression and affects attachment of gonocytes in Sertoli cell-gonocyte cocultures. Laslett, A.L., Li, L.H., Jester, W.F., Orth, J.M. Endocrinology (2000) [Pubmed]
  22. Cell-to-cell adherens junction formation and actin filament organization: similarities and differences between non-polarized fibroblasts and polarized epithelial cells. Yonemura, S., Itoh, M., Nagafuchi, A., Tsukita, S. J. Cell. Sci. (1995) [Pubmed]
  23. Identification and developmental regulation of cadherin messenger ribonucleic acids in the rat testis. Cyr, D.G., Blaschuk, O.W., Robaire, B. Endocrinology (1992) [Pubmed]
  24. Ectopic expression of PA2.26 antigen in epidermal keratinocytes leads to destabilization of adherens junctions and malignant progression. Scholl, F.G., Gamallo, C., Quintanilla, M. Lab. Invest. (2000) [Pubmed]
WikiGenes - Universities