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Gene Review

CDH3  -  cadherin 3, type 1, P-cadherin (placental)

Homo sapiens

Synonyms: CDHP, Cadherin-3, HJMD, P-cadherin, PCAD, ...
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Disease relevance of CDH3


Psychiatry related information on CDH3

  • Chronic delusional psychosis with hallucinations (CDHP) is commonly assumed to complicate the later stages of Parkinson's disease, as a side effect of antiparkinsonian medication [6].

High impact information on CDH3


Chemical compound and disease context of CDH3


Biological context of CDH3


Anatomical context of CDH3


Associations of CDH3 with chemical compounds

  • P-cadherin was detected in most, but not all, luminal epithelial cells, and was appropriately localized to cell-cell borders [16].
  • It has been demonstrated here that during cisplatin-induced apoptosis of human embryo retinoblasts both E- and P-cadherin were degraded by caspases, giving initially major polypeptide products of apparent molecular weights 48 K and 104 K respectively [19].
  • Like E- and P-cadherin, Ca(2+) treatment of normal and tumor-derived human keratinocytes resulted in c-Yes (and c-Src and Fyn), as well as their putative substrate p120(CTN), being recruited to cell-cell contacts [20].
  • We studied the developmental expression of nephrin, ZO-1 and P-cadherin in normal fetal kidneys and in NPHS1 kidneys [21].
  • Adhesion of cultured melanocytes to keratinocyte monolayers is abolished by pre-treatment of the melanocytes with trypsin/EDTA, which degrades E- and P-cadherins, is greatly reduced by anti-E-cadherin antibodies and is slightly reduced by antibodies to P-cadherin, alpha 2, alpha 3 and beta 1 integrins [22].

Physical interactions of CDH3


Regulatory relationships of CDH3


Other interactions of CDH3

  • Overexpression of P-cadherin was strongly associated with cytoplasmic accumulation of one of the catenins, p120ctn, and cadherin switching in PDAC cells [3].
  • Here, we show that when A431 cells are forced to express R-cadherin, they dramatically downregulate the expression of endogenous E- and P-cadherin [25].
  • Our data establish recessive mutations in CDH3 as the molecular cause of hypotrichosis with juvenile macular dystrophy and expand our understanding of the pathophysiology of this intriguing disorder [13].
  • (ii) To ascertain whether expression of P-cadherin is independent of or correlated with expression of its associated proteins--E-cadherin, beta-catenin, and gamma-catenin [26].
  • P-cadherin present in adenomas was functional with regard to catenin binding, and its expression was independent of APC mutational status [26].

Analytical, diagnostic and therapeutic context of CDH3


  1. Hypotrichosis with juvenile macular dystrophy is caused by a mutation in CDH3, encoding P-cadherin. Sprecher, E., Bergman, R., Richard, G., Lurie, R., Shalev, S., Petronius, D., Shalata, A., Anbinder, Y., Leibu, R., Perlman, I., Cohen, N., Szargel, R. Nat. Genet. (2001) [Pubmed]
  2. P-cadherin overexpression is an indicator of clinical outcome in invasive breast carcinomas and is associated with CDH3 promoter hypomethylation. Paredes, J., Albergaria, A., Oliveira, J.T., Jerónimo, C., Milanezi, F., Schmitt, F.C. Clin. Cancer Res. (2005) [Pubmed]
  3. Overexpressed P-cadherin/CDH3 promotes motility of pancreatic cancer cells by interacting with p120ctn and activating rho-family GTPases. Taniuchi, K., Nakagawa, H., Hosokawa, M., Nakamura, T., Eguchi, H., Ohigashi, H., Ishikawa, O., Katagiri, T., Nakamura, Y. Cancer Res. (2005) [Pubmed]
  4. P-Cadherin is a basal cell-specific epithelial marker that is not expressed in prostate cancer. Jarrard, D.F., Paul, R., van Bokhoven, A., Nguyen, S.H., Bova, G.S., Wheelock, M.J., Johnson, K.R., Schalken, J., Bussemakers, M., Isaacs, W.B. Clin. Cancer Res. (1997) [Pubmed]
  5. Identification of a novel tumor-associated antigen, cadherin 3/P-cadherin, as a possible target for immunotherapy of pancreatic, gastric, and colorectal cancers. Imai, K., Hirata, S., Irie, A., Senju, S., Ikuta, Y., Yokomine, K., Harao, M., Inoue, M., Tsunoda, T., Nakatsuru, S., Nakagawa, H., Nakamura, Y., Baba, H., Nishimura, Y. Clin. Cancer Res. (2008) [Pubmed]
  6. Chronic delusional hallucinatory psychosis in early-onset Parkinson's disease: drug-induced complication or sign of an idiopathic psychiatric illness? Cannas, A., Spissu, A., Floris, G.L., Saddi, M.V., Cossu, G., Melis, M., Tacconi, P., Milia, A., Mascia, M.M., Giagheddu, M. Neurol. Sci. (2001) [Pubmed]
  7. Expression of N-cadherin by human squamous carcinoma cells induces a scattered fibroblastic phenotype with disrupted cell-cell adhesion. Islam, S., Carey, T.E., Wolf, G.T., Wheelock, M.J., Johnson, K.R. J. Cell Biol. (1996) [Pubmed]
  8. Regulation of keratinocyte intercellular junction organization and epidermal morphogenesis by E-cadherin. Wheelock, M.J., Jensen, P.J. J. Cell Biol. (1992) [Pubmed]
  9. Epithelial (E-) and placental (P-) cadherin cell adhesion molecule expression in breast carcinoma. Rasbridge, S.A., Gillett, C.E., Sampson, S.A., Walsh, F.S., Millis, R.R. J. Pathol. (1993) [Pubmed]
  10. Anomalous expression of P-cadherin in breast carcinoma. Correlation with E-cadherin expression and pathological features. Palacios, J., Benito, N., Pizarro, A., Suárez, A., Espada, J., Cano, A., Gamallo, C. Am. J. Pathol. (1995) [Pubmed]
  11. Comparison of integrin, cadherin, and catenin expression in squamous cell carcinomas of the oral cavity. Bagutti, C., Speight, P.M., Watt, F.M. J. Pathol. (1998) [Pubmed]
  12. Expression of E-cadherin, P-cadherin and involucrin by normal and neoplastic keratinocytes in culture. Nicholson, L.J., Pei, X.F., Watt, F.M. Carcinogenesis (1991) [Pubmed]
  13. A missense mutation in CDH3, encoding P-cadherin, causes hypotrichosis with juvenile macular dystrophy. Indelman, M., Bergman, R., Lurie, R., Richard, G., Miller, B., Petronius, D., Ciubutaro, D., Leibu, R., Sprecher, E. J. Invest. Dermatol. (2002) [Pubmed]
  14. The gene for the cell adhesion molecule M-cadherin maps to mouse chromosome 8 and human chromosome 16q24.1-qter and is near the E-cadherin (uvomorulin) locus in both species. Kaupmann, K., Becker-Follmann, J., Scherer, G., Jockusch, H., Starzinski-Powitz, A. Genomics (1992) [Pubmed]
  15. Cadherin switching in ovarian cancer progression. Patel, I.S., Madan, P., Getsios, S., Bertrand, M.A., MacCalman, C.D. Int. J. Cancer (2003) [Pubmed]
  16. Inappropriate P-cadherin expression in the mouse mammary epithelium is compatible with normal mammary gland function. Radice, G.L., Sauer, C.L., Kostetskii, I., Peralta Soler, A., Knudsen, K.A. Differentiation (2003) [Pubmed]
  17. P-cadherin expression reduced in squamous cell carcinoma of the oral cavity: an indicatior of poor prognosis. Muñoz-Guerra, M.F., Marazuela, E.G., Fernández-Contreras, M.E., Gamallo, C. Cancer (2005) [Pubmed]
  18. Cadherin expression in glandular tumors of the cervix. Han, A.C., Edelson, M.I., Peralta Soler, A., Knudsen, K.A., Lifschitz-Mercer, B., Czernobilsky, B., Rosenblum, N.G., Salazar, H. Cancer (2000) [Pubmed]
  19. The fate of E- and P-cadherin during the early stages of apoptosis. Schmeiser, K., Grand, R.J. Cell Death Differ. (1999) [Pubmed]
  20. The catalytic activity of the Src family kinases is required to disrupt cadherin-dependent cell-cell contacts. Owens, D.W., McLean, G.W., Wyke, A.W., Paraskeva, C., Parkinson, E.K., Frame, M.C., Brunton, V.G. Mol. Biol. Cell (2000) [Pubmed]
  21. Role of nephrin in cell junction formation in human nephrogenesis. Ruotsalainen, V., Patrakka, J., Tissari, P., Reponen, P., Hess, M., Kestilä, M., Holmberg, C., Salonen, R., Heikinheimo, M., Wartiovaara, J., Tryggvason, K., Jalanko, H. Am. J. Pathol. (2000) [Pubmed]
  22. E-cadherin is the major mediator of human melanocyte adhesion to keratinocytes in vitro. Tang, A., Eller, M.S., Hara, M., Yaar, M., Hirohashi, S., Gilchrest, B.A. J. Cell. Sci. (1994) [Pubmed]
  23. Effect of hepatocyte growth factor on the expression of E- and P-cadherin in gastric carcinoma cell lines. Tannapfel, A., Yasui, W., Yokozaki, H., Wittekind, C., Tahara, E. Virchows Arch. (1994) [Pubmed]
  24. P-cadherin is up-regulated by the antiestrogen ICI 182,780 and promotes invasion of human breast cancer cells. Paredes, J., Stove, C., Stove, V., Milanezi, F., Van Marck, V., Derycke, L., Mareel, M., Bracke, M., Schmitt, F. Cancer Res. (2004) [Pubmed]
  25. Expression of inappropriate cadherins by epithelial tumor cells promotes endocytosis and degradation of E-cadherin via competition for p120(ctn). Maeda, M., Johnson, E., Mandal, S.H., Lawson, K.R., Keim, S.A., Svoboda, R.A., Caplan, S., Wahl, J.K., Wheelock, M.J., Johnson, K.R. Oncogene (2006) [Pubmed]
  26. Aberrant P-cadherin expression is an early event in hyperplastic and dysplastic transformation in the colon. Hardy, R.G., Tselepis, C., Hoyland, J., Wallis, Y., Pretlow, T.P., Talbot, I., Sanders, D.S., Matthews, G., Morton, D., Jankowski, J.A. Gut (2002) [Pubmed]
  27. Expression of P-cadherin identifies prostate-specific-antigen-negative cells in epithelial tissues of male sexual accessory organs and in prostatic carcinomas. Implications for prostate cancer biology. Soler, A.P., Harner, G.D., Knudsen, K.A., McBrearty, F.X., Grujic, E., Salazar, H., Han, A.C., Keshgegian, A.A. Am. J. Pathol. (1997) [Pubmed]
  28. E-, P-, and N-cadherin are co-expressed in the nasopharyngeal carcinoma cell line TW-039. Lou, P.J., Chen, W.P., Lin, C.T., DePhilip, R.M., Wu, J.C. J. Cell. Biochem. (1999) [Pubmed]
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