Gene Review:
CDH3 - cadherin 3, type 1, P-cadherin (placental)
Homo sapiens
Synonyms:
CDHP, Cadherin-3, HJMD, P-cadherin, PCAD, ...
Paredes,
Perlman,
Anbinder,
Lurie,
Cohen,
Wallis,
Sanders,
Rosenblum,
Peralta Soler,
Leibu,
Czernobilsky,
Szargel,
Sprecher,
Morton,
Talbot,
Tselepis,
Schmitt,
Oliveira,
Knudsen,
Petronius,
Albergaria,
Hardy,
Jerónimo,
Shalev,
Han,
Lifschitz-Mercer,
Bergman,
Pretlow,
Shalata,
Milanezi,
Jankowski,
Richard,
Hoyland,
Matthews,
Salazar,
Edelson,
- Hypotrichosis with juvenile macular dystrophy is caused by a mutation in CDH3, encoding P-cadherin. Sprecher, E., Bergman, R., Richard, G., Lurie, R., Shalev, S., Petronius, D., Shalata, A., Anbinder, Y., Leibu, R., Perlman, I., Cohen, N., Szargel, R. Nat. Genet. (2001)
- P-cadherin overexpression is an indicator of clinical outcome in invasive breast carcinomas and is associated with CDH3 promoter hypomethylation. Paredes, J., Albergaria, A., Oliveira, J.T., Jerónimo, C., Milanezi, F., Schmitt, F.C. Clin. Cancer Res. (2005)
- Overexpressed P-cadherin/CDH3 promotes motility of pancreatic cancer cells by interacting with p120ctn and activating rho-family GTPases. Taniuchi, K., Nakagawa, H., Hosokawa, M., Nakamura, T., Eguchi, H., Ohigashi, H., Ishikawa, O., Katagiri, T., Nakamura, Y. Cancer Res. (2005)
- P-Cadherin is a basal cell-specific epithelial marker that is not expressed in prostate cancer. Jarrard, D.F., Paul, R., van Bokhoven, A., Nguyen, S.H., Bova, G.S., Wheelock, M.J., Johnson, K.R., Schalken, J., Bussemakers, M., Isaacs, W.B. Clin. Cancer Res. (1997)
- Identification of a novel tumor-associated antigen, cadherin 3/P-cadherin, as a possible target for immunotherapy of pancreatic, gastric, and colorectal cancers. Imai, K., Hirata, S., Irie, A., Senju, S., Ikuta, Y., Yokomine, K., Harao, M., Inoue, M., Tsunoda, T., Nakatsuru, S., Nakagawa, H., Nakamura, Y., Baba, H., Nishimura, Y. Clin. Cancer Res. (2008)
- Chronic delusional hallucinatory psychosis in early-onset Parkinson's disease: drug-induced complication or sign of an idiopathic psychiatric illness? Cannas, A., Spissu, A., Floris, G.L., Saddi, M.V., Cossu, G., Melis, M., Tacconi, P., Milia, A., Mascia, M.M., Giagheddu, M. Neurol. Sci. (2001)
- Expression of N-cadherin by human squamous carcinoma cells induces a scattered fibroblastic phenotype with disrupted cell-cell adhesion. Islam, S., Carey, T.E., Wolf, G.T., Wheelock, M.J., Johnson, K.R. J. Cell Biol. (1996)
- Regulation of keratinocyte intercellular junction organization and epidermal morphogenesis by E-cadherin. Wheelock, M.J., Jensen, P.J. J. Cell Biol. (1992)
- Epithelial (E-) and placental (P-) cadherin cell adhesion molecule expression in breast carcinoma. Rasbridge, S.A., Gillett, C.E., Sampson, S.A., Walsh, F.S., Millis, R.R. J. Pathol. (1993)
- Anomalous expression of P-cadherin in breast carcinoma. Correlation with E-cadherin expression and pathological features. Palacios, J., Benito, N., Pizarro, A., Suárez, A., Espada, J., Cano, A., Gamallo, C. Am. J. Pathol. (1995)
- Comparison of integrin, cadherin, and catenin expression in squamous cell carcinomas of the oral cavity. Bagutti, C., Speight, P.M., Watt, F.M. J. Pathol. (1998)
- Expression of E-cadherin, P-cadherin and involucrin by normal and neoplastic keratinocytes in culture. Nicholson, L.J., Pei, X.F., Watt, F.M. Carcinogenesis (1991)
- A missense mutation in CDH3, encoding P-cadherin, causes hypotrichosis with juvenile macular dystrophy. Indelman, M., Bergman, R., Lurie, R., Richard, G., Miller, B., Petronius, D., Ciubutaro, D., Leibu, R., Sprecher, E. J. Invest. Dermatol. (2002)
- The gene for the cell adhesion molecule M-cadherin maps to mouse chromosome 8 and human chromosome 16q24.1-qter and is near the E-cadherin (uvomorulin) locus in both species. Kaupmann, K., Becker-Follmann, J., Scherer, G., Jockusch, H., Starzinski-Powitz, A. Genomics (1992)
- Cadherin switching in ovarian cancer progression. Patel, I.S., Madan, P., Getsios, S., Bertrand, M.A., MacCalman, C.D. Int. J. Cancer (2003)
- Inappropriate P-cadherin expression in the mouse mammary epithelium is compatible with normal mammary gland function. Radice, G.L., Sauer, C.L., Kostetskii, I., Peralta Soler, A., Knudsen, K.A. Differentiation (2003)
- P-cadherin expression reduced in squamous cell carcinoma of the oral cavity: an indicatior of poor prognosis. Muñoz-Guerra, M.F., Marazuela, E.G., Fernández-Contreras, M.E., Gamallo, C. Cancer (2005)
- Cadherin expression in glandular tumors of the cervix. Han, A.C., Edelson, M.I., Peralta Soler, A., Knudsen, K.A., Lifschitz-Mercer, B., Czernobilsky, B., Rosenblum, N.G., Salazar, H. Cancer (2000)
- The fate of E- and P-cadherin during the early stages of apoptosis. Schmeiser, K., Grand, R.J. Cell Death Differ. (1999)
- The catalytic activity of the Src family kinases is required to disrupt cadherin-dependent cell-cell contacts. Owens, D.W., McLean, G.W., Wyke, A.W., Paraskeva, C., Parkinson, E.K., Frame, M.C., Brunton, V.G. Mol. Biol. Cell (2000)
- Role of nephrin in cell junction formation in human nephrogenesis. Ruotsalainen, V., Patrakka, J., Tissari, P., Reponen, P., Hess, M., Kestilä, M., Holmberg, C., Salonen, R., Heikinheimo, M., Wartiovaara, J., Tryggvason, K., Jalanko, H. Am. J. Pathol. (2000)
- E-cadherin is the major mediator of human melanocyte adhesion to keratinocytes in vitro. Tang, A., Eller, M.S., Hara, M., Yaar, M., Hirohashi, S., Gilchrest, B.A. J. Cell. Sci. (1994)
- Effect of hepatocyte growth factor on the expression of E- and P-cadherin in gastric carcinoma cell lines. Tannapfel, A., Yasui, W., Yokozaki, H., Wittekind, C., Tahara, E. Virchows Arch. (1994)
- P-cadherin is up-regulated by the antiestrogen ICI 182,780 and promotes invasion of human breast cancer cells. Paredes, J., Stove, C., Stove, V., Milanezi, F., Van Marck, V., Derycke, L., Mareel, M., Bracke, M., Schmitt, F. Cancer Res. (2004)
- Expression of inappropriate cadherins by epithelial tumor cells promotes endocytosis and degradation of E-cadherin via competition for p120(ctn). Maeda, M., Johnson, E., Mandal, S.H., Lawson, K.R., Keim, S.A., Svoboda, R.A., Caplan, S., Wahl, J.K., Wheelock, M.J., Johnson, K.R. Oncogene (2006)
- Aberrant P-cadherin expression is an early event in hyperplastic and dysplastic transformation in the colon. Hardy, R.G., Tselepis, C., Hoyland, J., Wallis, Y., Pretlow, T.P., Talbot, I., Sanders, D.S., Matthews, G., Morton, D., Jankowski, J.A. Gut (2002)
- Expression of P-cadherin identifies prostate-specific-antigen-negative cells in epithelial tissues of male sexual accessory organs and in prostatic carcinomas. Implications for prostate cancer biology. Soler, A.P., Harner, G.D., Knudsen, K.A., McBrearty, F.X., Grujic, E., Salazar, H., Han, A.C., Keshgegian, A.A. Am. J. Pathol. (1997)
- E-, P-, and N-cadherin are co-expressed in the nasopharyngeal carcinoma cell line TW-039. Lou, P.J., Chen, W.P., Lin, C.T., DePhilip, R.M., Wu, J.C. J. Cell. Biochem. (1999)