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Gene Review

osa  -  CG7467 gene product from transcript CG7467-RE

Drosophila melanogaster

Synonyms: C819, CG7467, Dmel\CG7467, E(E2F)3C, OSA, ...
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High impact information on osa

  • We report here that the product of the trithorax group gene osa is required to repress such genes in the absence of the Wingless signal [1].
  • We have identified a novel gene, eyelid (eld), which is required for embryonic segmentation, development of the notum and wing margin, and photoreceptor differentiation [2].
  • Acetylation of the C terminus by p300 is not necessary for binding or promoter activation [3].
  • Instead, p300 acetylates p53-bound nucleosomes in the p21 promoter with spreading to the TATA box [3].
  • The Drosophila osa gene, like yeast SWI1, encodes an AT-rich interaction (ARID) domain protein [4].

Biological context of osa

  • Loss of maternal osa function causes severe segmentation defects, indicating that the function of osa is not limited to homeotic gene regulation [5].
  • Atro appears to be particularly closely related in function to the trxG gene osa, which encodes a component of the brahma chromatin remodeling complex [6].
  • CBP/p300 is a transcriptional co-activator that is recruited to enhancers by various DNA-binding proteins, including proteins whose activity is controlled by extracellular signals [7].
  • Reporter gene expression could be rescued from E1A inhibition by overexpression of CBP or p300 [8].
  • CBP and p300 act as coactivators of p65-driven gene activation and may play an important role in the cytokine-induced expression of various immune and inflammatory genes [8].

Associations of osa with chemical compounds

  • Although both STAT1alpha and STAT1beta bind to known STAT sites within in vitro assembled chromatin templates, only STAT1alpha, and not STAT1beta, in cooperation with p300 and acetyl-CoA, stimulated in vitro transcription from chromatin [9].
  • We conclude that chromatin remodeling by p300 in vivo makes TRAP/Mediator effective in stimulating transcription [9].
  • Although 17beta-estradiol (E2)-dependent HAT activity of steroid receptor coactivators 2 (SRC2) and p300 mediated by ERbeta could be detected, it was weaker than that mediated by ERalpha [10].
  • Secondly, hydroxylation of an asparagine residue in the C-terminal transactivation domain of HIFalpha directly prevents its interaction with the co-activator p300 [11].

Other interactions of osa

  • Regulation of Antennapedia by BRM and OSA proteins requires sequences 5' to the P2 promoter [5].
  • Finally, one revertant has a suppressing lesion in the osa locus far away from Antp [12].
  • eyelid antagonizes wingless signaling during Drosophila development and has homology to the Bright family of DNA-binding proteins [2].


  1. Osa-containing Brahma chromatin remodeling complexes are required for the repression of wingless target genes. Collins, R.T., Treisman, J.E. Genes Dev. (2000) [Pubmed]
  2. eyelid antagonizes wingless signaling during Drosophila development and has homology to the Bright family of DNA-binding proteins. Treisman, J.E., Luk, A., Rubin, G.M., Heberlein, U. Genes Dev. (1997) [Pubmed]
  3. Transcriptional regulation by p53 through intrinsic DNA/chromatin binding and site-directed cofactor recruitment. Espinosa, J.M., Emerson, B.M. Mol. Cell (2001) [Pubmed]
  4. Osa associates with the Brahma chromatin remodeling complex and promotes the activation of some target genes. Collins, R.T., Furukawa, T., Tanese, N., Treisman, J.E. EMBO J. (1999) [Pubmed]
  5. The trithorax group gene osa encodes an ARID-domain protein that genetically interacts with the brahma chromatin-remodeling factor to regulate transcription. Vázquez, M., Moore, L., Kennison, J.A. Development (1999) [Pubmed]
  6. A screen for genes that interact with the Drosophila pair-rule segmentation gene fushi tarazu. Kankel, M.W., Duncan, D.M., Duncan, I. Genetics (2004) [Pubmed]
  7. A function of CBP as a transcriptional co-activator during Dpp signalling. Waltzer, L., Bienz, M. EMBO J. (1999) [Pubmed]
  8. CREB-binding protein/p300 are transcriptional coactivators of p65. Gerritsen, M.E., Williams, A.J., Neish, A.S., Moore, S., Shi, Y., Collins, T. Proc. Natl. Acad. Sci. U.S.A. (1997) [Pubmed]
  9. Distinct transcriptional activation functions of STAT1alpha and STAT1beta on DNA and chromatin templates. Zakharova, N., Lymar, E.S., Yang, E., Malik, S., Zhang, J.J., Roeder, R.G., Darnell, J.E. J. Biol. Chem. (2003) [Pubmed]
  10. Isoflavones stimulate estrogen receptor-mediated core histone acetylation. Hong, T., Nakagawa, T., Pan, W., Kim, M.Y., Kraus, W.L., Ikehara, T., Yasui, K., Aihara, H., Takebe, M., Muramatsu, M., Ito, T. Biochem. Biophys. Res. Commun. (2004) [Pubmed]
  11. The role of iron and 2-oxoglutarate oxygenases in signalling. Hewitson, K.S., McNeill, L.A., Elkins, J.M., Schofield, C.J. Biochem. Soc. Trans. (2003) [Pubmed]
  12. The Drosophila homeotic mutation Nasobemia (AntpNs) and its revertants: an analysis of mutational reversion. Talbert, P.B., Garber, R.L. Genetics (1994) [Pubmed]
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