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Gene Review

IGFR1  -  insulin-like growth factor type 1 receptor

Ovis aries

 
 
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High impact information on IGFR1

 

Biological context of IGFR1

 

Anatomical context of IGFR1

  • Amniotic IGF-I supplementation of growth-restricted fetal sheep alters IGF-I and IGF receptor type 1 mRNA and protein levels in placental and fetal tissues [7].
  • The co-ordinate maximum expression of mRNA for both IGF-I and IGF-II, the type 1 IGF receptor and IGFBP-3 during the period when the gametes and embryo are in transit suggests a role for IGF-I and possibly IGF-II peptides in providing an oviductal environment propitious to conception and early embryonic growth and metabolism [6].
  • Type 1 IGF receptor expression was increased (P < 0. 01) in the luminal epithelium of the HM group and IGFBP-2 mRNA expression was highest in the placentome capsule of ewes in the HH group [8].
 

Associations of IGFR1 with chemical compounds

  • Furthermore they indicate that the actions of the metabolic hormones insulin and GH on ovarian progesterone synthesis are probably mediated directly through their own receptors rather than through either ovarian IGF-I synthesis or the type 1 IGF receptor [9].
  • Ovarian follicular expression of mRNA encoding the type I IGF receptor and IGF-binding protein-2 in sheep following five days of nutritional supplementation with glucose, glucosamine or lupins [10].
 

Analytical, diagnostic and therapeutic context of IGFR1

  • The distribution pattern of messenger RNAs (mRNAs) for insulin-like growth factor I (IGF-I), IGF-II, and the type 1 IGF receptor and the detection of IGF-binding sites in sections of ovine ovary were demonstrated using in situ hybridization and autoradiography [1].

References

  1. Localization of messenger ribonucleic acids for insulin-like growth factor I (IGF-I), IGF-II, and the type 1 IGF receptor in the ovine ovary throughout the estrous cycle. Perks, C.M., Denning-Kendall, P.A., Gilmour, R.S., Wathes, D.C. Endocrinology (1995) [Pubmed]
  2. Localization of insulin-like growth factor-I (IGF-I) and -II messenger ribonucleic acid and type 1 IGF receptors in the ovine uterus during the estrous cycle and early pregnancy. Stevenson, K.R., Gilmour, R.S., Wathes, D.C. Endocrinology (1994) [Pubmed]
  3. The lipolytic activity of low concentrations of insulin-like growth factors in ovine adipose tissue. Lewis, K.J., Molan, P.C., Bass, J.J., Gluckman, P.D. Endocrinology (1988) [Pubmed]
  4. Effect of pulsatile growth hormone administration to the growth-restricted fetal sheep on somatotrophic axis gene expression in fetal and placental tissues. Bloomfield, F.H., van Zijl, P.L., Bauer, M.K., Phua, H.H., Harding, J.E. Am. J. Physiol. Endocrinol. Metab. (2006) [Pubmed]
  5. Regulation of type 1 insulin-like growth factor (IGF) receptors and IGF-I mRNA by age and nutrition in ovine skeletal muscles. Oldham, J.M., Martyn, J.A., Kirk, S.P., Napier, J.R., Bass, J.J. J. Endocrinol. (1996) [Pubmed]
  6. Insulin-like growth factors and their binding proteins in the ovine oviduct during the oestrous cycle. Stevenson, K.R., Wathes, D.C. J. Reprod. Fertil. (1996) [Pubmed]
  7. Amniotic IGF-I supplementation of growth-restricted fetal sheep alters IGF-I and IGF receptor type 1 mRNA and protein levels in placental and fetal tissues. Shaikh, S., Bloomfield, F.H., Bauer, M.K., Phua, H.H., Gilmour, R.S., Harding, J.E. J. Endocrinol. (2005) [Pubmed]
  8. Effect of a high maternal dietary intake during mid-gestation on components of the utero-placental insulin-like growth factor (IGF) system in adolescent sheep with retarded placental development. Gadd, T.S., Aitken, R.P., Wallace, J.M., Wathes, D.C. J. Reprod. Fertil. (2000) [Pubmed]
  9. Regulation of insulin-like growth factor-I and progesterone synthesis by insulin and growth hormone in the ovine ovary. Wathes, D.C., Perks, C.M., Davis, A.J., Denning-Kendall, P.A. Biol. Reprod. (1995) [Pubmed]
  10. Ovarian follicular expression of mRNA encoding the type I IGF receptor and IGF-binding protein-2 in sheep following five days of nutritional supplementation with glucose, glucosamine or lupins. Muñoz-Gutiérrez, M., Blache, D., Martin, G.B., Scaramuzzi, R.J. Reproduction (2004) [Pubmed]
 
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