Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Editor

Personal info

View

About

Terms

Javascript disabled

Please enable Javascript support in your browser to use this application.

Instructions on how to enable JavaScript on different browsers can be found here: http://www.google.com/support/bin/answer.py?answer=23852.

[edit this page]

Gene Review:

NINJ1 - ninjurin 1

Homo sapiens

Synonyms: NIN1, NINJURIN, Nerve injury-induced protein 1, Ninjurin-1

Araki, T. et al., Mandich, P. et al., Kim, J.W. et al., Moon, A.R. et al., Katsura, H. et al., et al.

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of NINJ1

Ninjurin is a novel protein that is up-regulated after nerve injury both in dorsal root ganglion (DRG) neurons and in Schwann cells [1].
Exclusion of the ninjurin gene as a candidate for hereditary sensory neuropathies type I and type II [2].
These results suggest that ninjurin may play an important role in the development of HCC combined with cirrhosis and viral infection [3].

High impact information on NINJ1

We previously reported that ninjurin demonstrates properties of a homophilic adhesion molecule and promotes neurite outgrowth from primary cultured DRG neurons [1].
Furthermore, we show that the peptide which inhibits aggregation of Jurkat cells expressing ninjurin is also capable of blocking the ability of ninjurin to promote neurite extension from DRG neurons [1].
Using FISH analysis, the ninjurin gene was localized to human chromosome 9q22 [1].
The critical domain for ninjurin-mediated homophilic adhesion was localized to an 11-residue region (between Pro26 and Asn37) by mutagenesis and by employing synthetic oligopeptides as competitive inhibitors of ninjurin-mediated adhesion [1].
Ninjurin is a protein that is up-regulated in Schwann cells and neurons after peripheral nerve injury [2].

Biological context of NINJ1

Its role in promoting nerve regeneration and its expression in sensory neurons of dorsal root ganglia, as well as the chromosomal localization of the ninjurin gene, makes this gene a candidate for hereditary sensory neuropathies (HSN) [2].
Nerve injury induced a striking increase in SFK phosphorylation in the ipsilateral dorsal horn, and SFKs were activated in hyperactive microglia but not in neurons or astrocytes [4].
The nucleotide sequence of the putative promoter region shows 83% homology with the corresponding DNA sequence of human ninjurin gene that had been previously reported, and reveals a high degree of conservation between the two species [5].
Up-Regulation of ninjurin expression in human hepatocellular carcinoma associated with cirrhosis and chronic viral hepatitis [3].

Anatomical context of NINJ1

Nerve injury-induced depletion of tachykinin immunoreactivity in the somatosensory cortex of adult squirrel monkeys [6].

References

Mechanism of homophilic binding mediated by ninjurin, a novel widely expressed adhesion molecule. Araki, T., Zimonjic, D.B., Popescu, N.C., Milbrandt, J. J. Biol. Chem. (1997) [Pubmed]
Exclusion of the ninjurin gene as a candidate for hereditary sensory neuropathies type I and type II. Mandich, P., Bellone, E., Di Maria, E., Pigullo, S., Pizzuti, A., Schenone, A., Soriani, S., Varese, A., Windebank, A.J., Ajmar, F. Am. J. Med. Genet. (1999) [Pubmed]
Up-Regulation of ninjurin expression in human hepatocellular carcinoma associated with cirrhosis and chronic viral hepatitis. Kim, J.W., Moon, A.R., Kim, J.H., Yoon, S.Y., Oh, G.T., Choe, Y.K., Choe, I.S. Mol. Cells (2001) [Pubmed]
Activation of Src-family kinases in spinal microglia contributes to mechanical hypersensitivity after nerve injury. Katsura, H., Obata, K., Mizushima, T., Sakurai, J., Kobayashi, K., Yamanaka, H., Dai, Y., Fukuoka, T., Sakagami, M., Noguchi, K. J. Neurosci. (2006) [Pubmed]
Genomic DNA sequence and transcription factor binding sites of mouse ninjurin. Moon, A.R., Oh, G.T., Kim, J.W., Choi, Y.J., Choe, I.S. DNA Seq. (2001) [Pubmed]
Nerve injury-induced depletion of tachykinin immunoreactivity in the somatosensory cortex of adult squirrel monkeys. Cusick, C.G. Brain Res. (1991) [Pubmed]

Contributions to this collaborative article are from individual authors of WikiGenes or mined by the WikiGenes Data Mining Engine from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.About WikiGenes Open Access Licence Privacy Policy Terms of Use apsburg

NINJ1	Bos taurus
NINJ1	Canis lupus familiaris
ninj1	Danio rerio
NINJ1	Gallus gallus
NINJ1	Macaca mulatta
Ninj1	Mus musculus
NINJ1	Pan troglodytes
Ninj1	Rattus norvegicus
ninj1	Xenopus (Silurana) tropicalis

The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.