Disease relevance of IFN1

• These findings suggest that a single infusion of interferon-alpha stimulates a thromboxane cascade and causes transient pulmonary hypertension [1].
• Increased levels of antibodies against interferon-alpha in HIV-1 positive individuals may be explained by a common immunological epitope on the human interferon-alpha and HIV-1 gp41 [2].
• Pulmonary artery hypertension during interferon-alpha therapy for chronic myelogenous leukemia [3].
• These results indicate that induction of interferon alpha/beta appears to be a major mechanism for both natural resistance and pICLC-induced antiviral protection against MCMV and HSV-2 herpesvirus infections [4].
• The question of whether interferon alpha/beta is the common mechanism of antiviral action of synthetic immunomodulators was investigated in B6C3F1 mice infected with Semliki Forest virus [5].

High impact information on IFN1

• We report here the primary amino-acid sequence of oTP-1 as inferred from a cloned complementary DNA and demonstrate that the protein is most probably an interferon-alpha [6].
• Human peripheral blood mononuclear leukocytes cocultured with WISH human amnion cells or K562 tumor cells rapidly produce interferon-alpha (IFN) [7].
• A gene encoding ovine interferon alpha (IFN alpha) was identified from an ovine liver genomic library [8].
• However, interferon-alpha itself or increased thromboxane A2 might not affect the pulmonary vascular permeability in sheep [1].
• In addition, OKY-046 [sodium-3[4-(1-imidazolylmethyl)phenyl]-2-propenoic acid] (10 mg kg(-1)), a selective thromboxane synthase inhibitor, significantly prevented the interferon-alpha-induced pulmonary hypertension and thromboxane B2 production [1].

Biological context of IFN1

• At 1 h after intravenous interferon-alpha administration (18 x 10(6) I.U.), pulmonary arterial pressure and pulmonary vascular resistance were significantly increased compared to the baseline values [1].
• Counteracting effect of interferon-alpha and -beta on interferon- gamma-induced production of nitric oxide which is suppressive for antibody response [9].
• Interferon-alpha elevates pulmonary blood pressure in sheep--the role of thromboxane cascade [1].
• Thus, interferon-alpha 2 (which has sequence homology with oTP-1) acts on the ovine endometrium, eliciting similar biological responses to those of oTP-1 [10].
• Expression of the c-fos proto-oncogene by ovine conceptuses was analyzed by Northern and slot blots and indirect immunohistofluorescence in relation to the expression of the embryonic interferon-alpha (oTP) during implantation. c-fos was expressed initially in the trophoblast, and then in the allantois, when this tissue began to develop (day 17) [11].

Anatomical context of IFN1

• Interferon-alpha mimics effects of ovine trophoblast protein 1 on prostaglandin and protein secretion by ovine endometrial cells in vitro [10].
• Effects of interferon-alpha/beta and interferon-gamma preparations on phagocytosis by mouse peritoneal macrophages [12].
• Effects of interferon alpha on the sheep erythrocyte "receptor" of human lymphocytes [13].

Associations of IFN1 with chemical compounds

• Fluorography of two dimensional polyacrylamide gel electrophoretic analyses of proteins secreted by the cells following 35S-methionine incorporation, revealed that synthesis and secretion of the same "pregnancy-related" proteins was stimulated by both interferon-alpha 2 and oTP-1 [10].

References