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Gene Review

IFN1  -  interferon-alpha 1

Ovis aries

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Disease relevance of IFN1


High impact information on IFN1


Biological context of IFN1


Anatomical context of IFN1


Associations of IFN1 with chemical compounds

  • Fluorography of two dimensional polyacrylamide gel electrophoretic analyses of proteins secreted by the cells following 35S-methionine incorporation, revealed that synthesis and secretion of the same "pregnancy-related" proteins was stimulated by both interferon-alpha 2 and oTP-1 [10].


  1. Interferon-alpha elevates pulmonary blood pressure in sheep--the role of thromboxane cascade. Hanaoka, M., Kubo, K., Hayano, T., Koizumi, T., Kobayashi, T. Eur. J. Pharmacol. (1999) [Pubmed]
  2. Increased levels of antibodies against interferon-alpha in HIV-1 positive individuals may be explained by a common immunological epitope on the human interferon-alpha and HIV-1 gp41. Chen, Y.H., Stoiber, H., Dierich, M.P. Immunol. Lett. (1997) [Pubmed]
  3. Pulmonary artery hypertension during interferon-alpha therapy for chronic myelogenous leukemia. Fruehauf, S., Steiger, S., Topaly, J., Ho, A.D. Ann. Hematol. (2001) [Pubmed]
  4. Biological response modifier-mediated resistance to herpesvirus infections requires induction of alpha/beta interferon. Kunder, S.C., Kelly, K.M., Morahan, P.S. Antiviral Res. (1993) [Pubmed]
  5. Varying role of alpha/beta interferon in the antiviral efficacy of synthetic immunomodulators against Semliki Forest virus infection. Morahan, P.S., Pinto, A., Stewart, D., Murasko, D.M., Brinton, M.A. Antiviral Res. (1991) [Pubmed]
  6. Interferon-like sequence of ovine trophoblast protein secreted by embryonic trophectoderm. Imakawa, K., Anthony, R.V., Kazemi, M., Marotti, K.R., Polites, H.G., Roberts, R.M. Nature (1987) [Pubmed]
  7. Properties of human natural interferon-producing cells stimulated by tumor cell lines. Rönnblom, L., Ramstedt, U., Alm, G.V. Eur. J. Immunol. (1983) [Pubmed]
  8. Cloning and analysis of a gene encoding ovine interferon alpha-II. Whaley, A.E., Carroll, R.S., Imakawa, K. Gene (1991) [Pubmed]
  9. Counteracting effect of interferon-alpha and -beta on interferon- gamma-induced production of nitric oxide which is suppressive for antibody response. Deguchi, M., Inaba, K., Muramatsu, S. Immunol. Lett. (1995) [Pubmed]
  10. Interferon-alpha mimics effects of ovine trophoblast protein 1 on prostaglandin and protein secretion by ovine endometrial cells in vitro. Salamonsen, L.A., Stuchbery, S.J., O'Grady, C.M., Godkin, J.D., Findlay, J.K. J. Endocrinol. (1988) [Pubmed]
  11. Co-expression of the proto-oncogene fos (c-fos) and an embryonic interferon (ovine trophoblastin) by sheep conceptuses during implantation. Xavier, F., Guillomot, M., Charlier, M., Martal, J., Gaye, P. Biol. Cell (1991) [Pubmed]
  12. Effects of interferon-alpha/beta and interferon-gamma preparations on phagocytosis by mouse peritoneal macrophages. Rollag, H., Degré, M., Sonnenfeld, G. Scand. J. Immunol. (1984) [Pubmed]
  13. Effects of interferon alpha on the sheep erythrocyte "receptor" of human lymphocytes. Fuhlbrigge, R.C., Edwards, B.S., Borden, E.C. J. Interferon Res. (1984) [Pubmed]
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