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Gene Review

ORM2  -  orosomucoid 2

Homo sapiens

Synonyms: AGP 2, AGP-B, AGP-B', AGP2, Alpha-1-acid glycoprotein 2, ...
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High impact information on ORM2

  • The human genome contains three alpha 1-glycoprotein genes (AGP-A, AGP-B, and AGP-B') encoding for slightly different forms of the protein [1].
  • Starch synthesis was inhibited within 24 h of tuber detachment, even though the catalytic subunit of AGPase (AGPB) and overall AGPase activity remained high, the substrates ATP and Glc-1-P increased, and the glycerate-3-phosphate/inorganic orthophosphate (the allosteric activator and inhibitor, respectively) ratio increased [2].
  • CONCLUSIONS: The disposition of the active enantiomer, R -methadone, can be predicted in part by CYP3A activity and protein binding to alpha1-AGP (ORM2), whereas S-methadone disposition is not well explained by the factors examined in this study [3].
  • It is proposed to use a different alpha-numerical nomenclature for the phenotypes of the ORM1 and ORM2 systems [4].
  • The Con-A intermediately reactive and the Con-A reactive glycoforms, AGP-B and AGP-C, showed weak reaction in the cytoplasm of spermatocytes, spermatids and Sertoli cells and, at the last stages in the spermatogenic cycle, a very strong reaction in the late elongated spermatids and the apical extensions of Sertoli cells [5].

Biological context of ORM2


Anatomical context of ORM2

  • FMLP induced the most consistent response of neutrophils, which changed only slightly in the presence of AGP and AGP-B; however, low concentrations of AGP-A inhibited this response [11].

Associations of ORM2 with chemical compounds


Other interactions of ORM2

  • (2) The AGP2 gene of the child, inherited from the father, was duplicated, as revealed by long-range polymerase chain reaction [15].


  1. Expression of human alpha 1-acid glycoprotein genes in cultured cells and in transgenic mice. Dente, L., Rüther, U., Tripodi, M., Wagner, E.F., Cortese, R. Genes Dev. (1988) [Pubmed]
  2. Starch synthesis in potato tubers is regulated by post-translational redox modification of ADP-glucose pyrophosphorylase: a novel regulatory mechanism linking starch synthesis to the sucrose supply. Tiessen, A., Hendriks, J.H., Stitt, M., Branscheid, A., Gibon, Y., Farré, E.M., Geigenberger, P. Plant Cell (2002) [Pubmed]
  3. Pharmacokinetics and pharmacodynamics of methadone enantiomers after a single oral dose of racemate. Boulton, D.W., Arnaud, P., DeVane, C.L. Clin. Pharmacol. Ther. (2001) [Pubmed]
  4. Subtyping of orosomucoid 1 (ORM1) by isoelectric focusing in agarose and polyacrylamide gels. Thymann, M., Weidinger, S. Electrophoresis (1988) [Pubmed]
  5. Two lectin-like receptors for alpha 1-acid glycoprotein in mouse testis. Andersen, U.O., Kirkeby, S., Bøg-Hansen, T.C. J. Mol. Recognit. (1996) [Pubmed]
  6. Orosomucoid 1 and orosomucoid 2 types in the Taiwanese and Japanese: evidence for five new orosomucoid variants. Umetsu, K., Yuasa, I., Chen, E.R., Kudo, T., Suzuki, T. Electrophoresis (1988) [Pubmed]
  7. Genetic study of orosomucoid by isoelectric focusing and immunoprinting in patients with carcinoma. Mittermüller, J., Weidinger, S. Electrophoresis (1992) [Pubmed]
  8. Orosomucoid (ORM) typing by isoelectric focusing: evidence for several new variants including ORM1 and ORM2 silent alleles. Yuasa, I., Umetsu, K., Suenaga, K., Ikebuchi, J., Suzuki, T. Vox Sang. (1990) [Pubmed]
  9. Influence of the ORM1 phenotypes on serum unbound concentration and protein binding of quinidine. Li, J.H., Xu, J.Q., Cao, X.M., Ni, L., Li, Y., Zhuang, Y.Y., Gong, J.B. Clin. Chim. Acta (2002) [Pubmed]
  10. Orosomucoid (ORM1 and ORM2) types in the Spanish Basque Country, Galicia and northern Portugal. Montiel, M.D., Carracedo, A., Blazquez-Caeiro, J.L., Andrade-Vide, C. Hum. Hered. (1990) [Pubmed]
  11. Modification of the functional activity of neutrophils treated with acute phase response proteins. Timoshenko, A.V., Bovin, N.V., Shiyan, S.D., Vakhrushev, S.Y., André, S., Gabius, H.J. Biochemistry Mosc. (1998) [Pubmed]
  12. Orosomucoid (ORM) typing by isoelectric focusing: evidence for an additional duplicated ORM1 locus haplotype and close linkage of two ORM loci. Yuasa, I., Umetsu, K., Suenaga, K. Am. J. Hum. Genet. (1988) [Pubmed]
  13. Population-based analysis of methadone distribution and metabolism using an age-dependent physiologically based pharmacokinetic model. Yang, F., Tong, X., McCarver, D.G., Hines, R.N., Beard, D.A. Journal of pharmacokinetics and pharmacodynamics. (2006) [Pubmed]
  14. The rearrangement of the human alpha(1)-acid glycoprotein/orosomucoid gene: evidence for tandemly triplicated genes consisting of two AGP1 and one AGP2. Nakamura, H., Yuasa, I., Umetsu, K., Nakagawa, M., Nanba, E., Kimura, K. Biochem. Biophys. Res. Commun. (2000) [Pubmed]
  15. Characterization of genomic rearrangements of the alpha1-acid glycoprotein/orosomucoid gene in Ghanaians. Yuasa, I., Nakamura, H., Henke, L., Henke, J., Nakagawa, M., Irizawa, Y., Umetsu, K. J. Hum. Genet. (2001) [Pubmed]
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