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Gene Review

ORM1  -  orosomucoid 1

Homo sapiens

Synonyms: AGP 1, AGP-A, AGP1, Alpha-1-acid glycoprotein 1, HEL-S-153w, ...
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Disease relevance of ORM1


Psychiatry related information on ORM1


High impact information on ORM1


Chemical compound and disease context of ORM1


Biological context of ORM1


Anatomical context of ORM1


Associations of ORM1 with chemical compounds

  • In this study a modified isoelectric focusing, in which glycerin was omitted from gels, was used to differentiate a new variant ORM1 5 from ORM2 3 [17].
  • ORM1 phenotyping by isoelectric focusing in agarose or polyacrylamide gel combined with either print immunofixation or enzyme-linked immunoblotting is described, and population and family data from Denmark and Southern Germany are given [24].
  • The functional heterogeneity of ORM1 could be responsible for the differences in plasma binding of quinidine [20].
  • Four of the seven systems (F13A, ORM1, AHSG, C6) have not been studied previously in sub-Saharan Africa, and one system (C7) has never been examined in any population of African ancestry [25].
  • The variant allele originating from ORMi*S was characterized by a G-to-A transition, resulting in an amino acid change from valine to methionine, which is also detected in ORM1 F2, a form that is common in Europeans [26].

Physical interactions of ORM1

  • Equine haptoglobin (Hp) and haptoglobin-haemoglobin complex (Hp-Hb) are metabolised in the hen parenchymal cells of the liver in which endocytosis was inhibited by agalacto-orosomucoid (AGOR) or native orosomucoid (OR) [27].

Other interactions of ORM1


Analytical, diagnostic and therapeutic context of ORM1


  1. Orosomucoid and haptoglobin types in patients with sarcoidosis. Fan, C., Nylander, P.O., Sikström, C., Thunell, M. Exp. Clin. Immunogenet. (1995) [Pubmed]
  2. Orosomucoid types in allergic contact dermatitis. Fan, C. Hum. Hered. (1995) [Pubmed]
  3. Expression of human alpha 1-acid glycoprotein genes in cultured cells and in transgenic mice. Dente, L., Rüther, U., Tripodi, M., Wagner, E.F., Cortese, R. Genes Dev. (1988) [Pubmed]
  4. Linkage analysis of depression spectrum disease. Wilson, A.F., Tanna, V.L., Winokur, G., Elston, R.C., Hill, E.M. Biol. Psychiatry (1989) [Pubmed]
  5. Lymphocyte stimulation in vitro by orosomucoid glycoprotein. Singh, V.K., Fudenberg, H.H. Immunol. Lett. (1986) [Pubmed]
  6. Serum concentrations of orosomucoid: improved decision-making for tapering prednisolone therapy in patients with active inflammatory bowel disease? Kjeldsen, J., Lauritsen, K., De Muckadell, O.B. Scand. J. Gastroenterol. (1997) [Pubmed]
  7. Soluble transferrin receptor (sTfR): biological variations and reference limits. Raya, G., Henny, J., Steinmetz, J., Herbeth, B., Siest, G. Clin. Chem. Lab. Med. (2001) [Pubmed]
  8. Plasma levels of complement factors 3 and 4, orosomucoid and opsonic functions in anorexia nervosa. Palmblad, J., Fohlin, L., Norberg, R. Acta paediatrica Scandinavica. (1979) [Pubmed]
  9. A placebo-controlled, double-blind, randomized trial of cyclosporine therapy in active chronic Crohn's disease. Brynskov, J., Freund, L., Rasmussen, S.N., Lauritsen, K., de Muckadell, O.S., Williams, N., MacDonald, A.S., Tanton, R., Molina, F., Campanini, M.C. N. Engl. J. Med. (1989) [Pubmed]
  10. Inhibition of platelet aggregation by native and desialised alpha-1 acid glycoprotein. Costello, M., Fiedel, B.A., Gewurz, H. Nature (1979) [Pubmed]
  11. Inflammation-induced expression of sialyl Lewis X-containing glycan structures on alpha 1-acid glycoprotein (orosomucoid) in human sera. De Graaf, T.W., Van der Stelt, M.E., Anbergen, M.G., van Dijk, W. J. Exp. Med. (1993) [Pubmed]
  12. Synergistic interaction between ORM1 and C3 types in disease associations. Fan, C., Nylander, P.O., Stendahl, U., Thunell, M., Beckman, L. Exp. Clin. Immunogenet. (1995) [Pubmed]
  13. Serum sialic acid and sialoglycoproteins in asymptomatic carotid artery atherosclerosis. ARIC Investigators. Atherosclerosis Risk in Communities. Lindberg, G., Råstam, L., Nilsson-Ehle, P., Lundblad, A., Ranstam, J., Folsom, A.R., Burke, G.L. Atherosclerosis (1999) [Pubmed]
  14. Renal excretion of proteins and enzymes in workers exposed to cadmium. Bernard, A., Buchet, J.P., Roels, H., Masson, P., Lauwerys, R. Eur. J. Clin. Invest. (1979) [Pubmed]
  15. Effects of high dose medroxyprogesterone acetate treatment on antithrombin III and other plasma proteins in males with renal cell or prostatic carcinoma. Nilsson, T.K., Tomic, R., Ljungberg, B. Scandinavian journal of urology and nephrology. (1989) [Pubmed]
  16. Double blind, placebo controlled trial of metronidazole in Crohn's disease. Sutherland, L., Singleton, J., Sessions, J., Hanauer, S., Krawitt, E., Rankin, G., Summers, R., Mekhjian, H., Greenberger, N., Kelly, M. Gut (1991) [Pubmed]
  17. Orosomucoid (ORM) typing by isoelectric focusing: evidence for an additional duplicated ORM1 locus haplotype and close linkage of two ORM loci. Yuasa, I., Umetsu, K., Suenaga, K. Am. J. Hum. Genet. (1988) [Pubmed]
  18. Genetic study of orosomucoid by isoelectric focusing and immunoprinting in patients with carcinoma. Mittermüller, J., Weidinger, S. Electrophoresis (1992) [Pubmed]
  19. Genetic polymorphism of orosomucoid (ORM1 and ORM2) in Lombardy (Italy). Cerri, N., De Ferrari, F. Int. J. Legal Med. (1992) [Pubmed]
  20. Influence of the ORM1 phenotypes on serum unbound concentration and protein binding of quinidine. Li, J.H., Xu, J.Q., Cao, X.M., Ni, L., Li, Y., Zhuang, Y.Y., Gong, J.B. Clin. Chim. Acta (2002) [Pubmed]
  21. Structure and expression of the genes coding for human alpha 1-acid glycoprotein. Dente, L., Pizza, M.G., Metspalu, A., Cortese, R. EMBO J. (1987) [Pubmed]
  22. The influence of alpha1-acid glycoprotein (orosomucoid) and its glycoforms on the function of human thyrocytes and CHO cells transfected with the human TSH receptor. Zimmermann-Belsing, T., Rasmussen, A.K., Feldt-Rasmussen, U., Bøg-Hansen, T.C. Mol. Cell. Endocrinol. (2002) [Pubmed]
  23. Two lectin-like receptors for alpha 1-acid glycoprotein in mouse testis. Andersen, U.O., Kirkeby, S., Bøg-Hansen, T.C. J. Mol. Recognit. (1996) [Pubmed]
  24. Subtyping of orosomucoid 1 (ORM1) by isoelectric focusing in agarose and polyacrylamide gels. Thymann, M., Weidinger, S. Electrophoresis (1988) [Pubmed]
  25. Genetic studies on the Senegal population. II. Polymorphisms of the plasma proteins F13A, F13B, ORM1, AHSG, C6, C7, and APOC2. Corbo, R.M., Scacchi, R., Cossu, G., Brega, A., Scozzari, R. Hum. Biol. (1994) [Pubmed]
  26. Characterization of genomic rearrangements of the alpha1-acid glycoprotein/orosomucoid gene in Ghanaians. Yuasa, I., Nakamura, H., Henke, L., Henke, J., Nakagawa, M., Irizawa, Y., Umetsu, K. J. Hum. Genet. (2001) [Pubmed]
  27. Effect of inhibition of carbohydrate-mediated endocytosis on catabolism of equine haptoglobin and its complex with haemoglobin in hen. Woźniak, M. Acta Biochim. Pol. (1986) [Pubmed]
  28. Genetic polymorphisms of orosomucoid and alpha-2-HS-glycoprotein in a Philippine population. Umetsu, K., Yuasa, I., Nishimura, H., Sasaki, H., Suzuki, T. Hum. Hered. (1988) [Pubmed]
  29. Regional assignment of the loci for adenylate kinase to 9q32 and for alpha 1-acid glycoprotein to 9q31-q32. A locus for Goltz syndrome in region 9q32-qter? Zuffardi, O., Caiulo, A., Maraschio, P., Tupler, R., Bianchi, E., Amisano, P., Beluffi, G., Moratti, R., Liguri, G. Hum. Genet. (1989) [Pubmed]
  30. Study of the expression of the genetic variants of human alpha1-acid glycoprotein in healthy subjects using isoelectric focusing and immunoblotting. Duché, J.C., Hervé, F., Tillement, J.P. J. Chromatogr. B Biomed. Sci. Appl. (1998) [Pubmed]
  31. Secretion of immunoglobulins and plasma proteins from the colonic mucosa: an in vivo study in man. Prigent-Delecourt, L., Coffin, B., Colombel, J.F., Dehennin, J.P., Vaerman, J.P., Rambaud, J.C. Clin. Exp. Immunol. (1995) [Pubmed]
  32. Markers of inflammation and prediction of diabetes mellitus in adults (Atherosclerosis Risk in Communities study): a cohort study. Schmidt, M.I., Duncan, B.B., Sharrett, A.R., Lindberg, G., Savage, P.J., Offenbacher, S., Azambuja, M.I., Tracy, R.P., Heiss, G. Lancet (1999) [Pubmed]
  33. Preanalytical handling of stored urine samples, and measurement of beta 2-microglobulin, orosomucoid, albumin, transferrin and immunoglobulin G in urine by enzyme-linked immunosorbent assays (ELISA). Vittinghus, E. Scand. J. Clin. Lab. Invest. (1990) [Pubmed]
  34. A comparative study of the protein pattern in serum and synovial fluid. Willumsen, L., Friis, J. Scand. J. Rheumatol. (1975) [Pubmed]
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