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Ntm  -  neurotrimin

Rattus norvegicus

Synonyms: GP65, Hnt, Neurotrimin, Nt, RNU16845
 
 
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Disease relevance of Hnt

  • In contrast to conventional growth-promoting activity of Ig superfamily members, LAMP strongly inhibits the outgrowth of Ntm-expressing dorsal root ganglion (DRG) neurons in a heterophilic manner [1].
  • Neurotrimin expression during cerebellar development suggests roles in axon fasciculation and synaptogenesis [2].
 

High impact information on Hnt

  • Neurotrimin is also expressed at high levels in the olfactory bulb, neural retina, dorsal root ganglia, spinal cord, and in a graded distribution in the basal ganglia and hippocampus [3].
  • Cloning of neurotrimin defines a new subfamily of differentially expressed neural cell adhesion molecules [3].
  • Neurotrimin is expressed at high levels in several developing projection systems: in neurons of the thalamus, subplate, and lower cortical laminae in the forebrain and in the pontine nucleus, cerebellar granule cells, and Purkinje cells in the hindbrain [3].
  • Since this protein shows high sequence similarity to IgLON family members including LAMP, OBCAM, neurotrimin, CEPU-1, AvGP50, and GP55, we termed this protein Kilon (a kindred of IgLON) [4].
  • We previously reported that LAMP and Ntm promote adhesion and neurite outgrowth via a homophilic mechanism, suggesting that these proteins promote the formation of specific neuronal circuits by homophilic interactions [1].
 

Anatomical context of Hnt

  • By P21, neurotrimin reactivity decreased on the surfaces of neuronal somata, dendrites and axons but remained at excitatory synaptic contact sites in both the molecular and granular layers [2].
  • Immuno-EM revealed expression of neurotrimin on the surface of unmyelinated axons but not on astrocytes or oligodendroglia [2].
 

Other interactions of Hnt

 

Analytical, diagnostic and therapeutic context of Hnt

  • Characterization of the expression of neurotrimin and OBCAM in the developing CNS by in situ hybridization reveals that these proteins are differentially expressed during development [3].

References

  1. Complementary expression and heterophilic interactions between IgLON family members neurotrimin and LAMP. Gil, O.D., Zhang, L., Chen, S., Ren, Y.Q., Pimenta, A., Zanazzi, G., Hillman, D., Levitt, P., Salzer, J.L. J. Neurobiol. (2002) [Pubmed]
  2. Neurotrimin expression during cerebellar development suggests roles in axon fasciculation and synaptogenesis. Chen, S., Gil, O., Ren, Y.Q., Zanazzi, G., Salzer, J.L., Hillman, D.E. J. Neurocytol. (2001) [Pubmed]
  3. Cloning of neurotrimin defines a new subfamily of differentially expressed neural cell adhesion molecules. Struyk, A.F., Canoll, P.D., Wolfgang, M.J., Rosen, C.L., D'Eustachio, P., Salzer, J.L. J. Neurosci. (1995) [Pubmed]
  4. Characterization of a novel rat brain glycosylphosphatidylinositol-anchored protein (Kilon), a member of the IgLON cell adhesion molecule family. Funatsu, N., Miyata, S., Kumanogoh, H., Shigeta, M., Hamada, K., Endo, Y., Sokawa, Y., Maekawa, S. J. Biol. Chem. (1999) [Pubmed]
 
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