Gene Review:
Chek2 - checkpoint kinase 2
Mus musculus
Synonyms:
CHK2, CHK2 checkpoint homolog, Cds1, Checkpoint kinase 2, Chk2, ...
- Chk2 is dispensable for p53-mediated G1 arrest but is required for a latent p53-mediated apoptotic response. Jack, M.T., Woo, R.A., Hirao, A., Cheung, A., Mak, T.W., Lee, P.W. Proc. Natl. Acad. Sci. U.S.A. (2002)
- Chk2 is a tumor suppressor that regulates apoptosis in both an ataxia telangiectasia mutated (ATM)-dependent and an ATM-independent manner. Hirao, A., Cheung, A., Duncan, G., Girard, P.M., Elia, A.J., Wakeham, A., Okada, H., Sarkissian, T., Wong, J.A., Sakai, T., De Stanchina, E., Bristow, R.G., Suda, T., Lowe, S.W., Jeggo, P.A., Elledge, S.J., Mak, T.W. Mol. Cell. Biol. (2002)
- A role for the deubiquitinating enzyme USP28 in control of the DNA-damage response. Zhang, D., Zaugg, K., Mak, T.W., Elledge, S.J. Cell (2006)
- Chk2-deficient mice exhibit radioresistance and defective p53-mediated transcription. Takai, H., Naka, K., Okada, Y., Watanabe, M., Harada, N., Saito, S., Anderson, C.W., Appella, E., Nakanishi, M., Suzuki, H., Nagashima, K., Sawa, H., Ikeda, K., Motoyama, N. EMBO J. (2002)
- Chk2 mediates stabilization of the FoxM1 transcription factor to stimulate expression of DNA repair genes. Tan, Y., Raychaudhuri, P., Costa, R.H. Mol. Cell. Biol. (2007)
- Oncolytic adenovirus-mediated transfer of the antisense chk2 selectively inhibits tumor growth in vitro and in vivo. Chen, G., Zhou, J., Gao, Q., Huang, X., Li, K., Zhuang, L., Huang, M., Xu, G., Wang, S., Lu, Y., Ma, D. Cancer Gene Ther. (2006)
- Restoration of an absent G1 arrest and protection from apoptosis in embryonic stem cells after ionizing radiation. Hong, Y., Stambrook, P.J. Proc. Natl. Acad. Sci. U.S.A. (2004)
- Plumbagin induces G2-M arrest and autophagy by inhibiting the AKT/mammalian target of rapamycin pathway in breast cancer cells. Kuo, P.L., Hsu, Y.L., Cho, C.Y. Mol. Cancer Ther. (2006)
- Hus1 acts upstream of chk1 in a mammalian DNA damage response pathway. Weiss, R.S., Matsuoka, S., Elledge, S.J., Leder, P. Curr. Biol. (2002)
- Ataxia telangiectasia-mutated protein can regulate p53 and neuronal death independent of Chk2 in response to DNA damage. Keramaris, E., Hirao, A., Slack, R.S., Mak, T.W., Park, D.S. J. Biol. Chem. (2003)
- p53 Binding protein 53BP1 is required for DNA damage responses and tumor suppression in mice. Ward, I.M., Minn, K., van Deursen, J., Chen, J. Mol. Cell. Biol. (2003)
- DNA-dependent protein kinase and checkpoint kinase 2 synergistically activate a latent population of p53 upon DNA damage. Jack, M.T., Woo, R.A., Motoyama, N., Takai, H., Lee, P.W. J. Biol. Chem. (2004)