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Gene Review

SH3GLB1  -  SH3-domain GRB2-like endophilin B1

Homo sapiens

Synonyms: Bax-interacting factor 1, Bif-1, CGI-61, Endophilin-B1, KIAA0491, ...
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Disease relevance of SH3GLB1


High impact information on SH3GLB1


Biological context of SH3GLB1

  • SH3GLB1 and SH3GLB2 do not significantly influence the onset and time course of Bax-mediated apoptosis in HeLa or 293T cells [5].
  • SH3GLB1 shows strong similarities to the SH3 domain-containing proteins of the endophilin family and presumably represents the human homologue of the potential Caenorhabditis elegans SH3 containing-protein identified by systematic translation of the C. elegans genome (GenBank Accession No. U46675) [5].
  • Overexpression of Bif-1 promotes Bax conformational change, caspase activation, and apoptotic cell death in FL5.12 cells following interleukin-3 deprivation [6].
  • Bif-1 is an evolutionarily conserved cytoplasmic protein that contains a predicted Src homology 3 (SH3) domain located near its C terminus but shares no significant homology with members of the Bcl-2 family [6].
  • The endophilin B1 gene gives rise to at least three splice variants, endophilin B1a, which shows a widespread tissue distribution, and endophilins B1b and B1c, which appear to be brain-specific [4].

Anatomical context of SH3GLB1


Other interactions of SH3GLB1

  • DLP1 also caused global morphological changes in MOM-like liposomes, but DLP1 did not stimulate BAX-permeabilizing function in the absence or presence of Bif-1 [7].

Analytical, diagnostic and therapeutic context of SH3GLB1

  • Molecular cloning and characterization of Bif-1. A novel Src homology 3 domain-containing protein that associates with Bax [6].
  • Bif-1 is capable of interacting with Bax as demonstrated by yeast two-hybrid, coimmunoprecipitation, and immunofluorescence studies [6].


  1. Decreased expression of tumour suppressor Bax-interacting factor-1 (Bif-1), a Bax activator, in gastric carcinomas. Lee, J.W., Jeong, E.G., Soung, Y.H., Nam, S.W., Lee, J.Y., Yoo, N.J., Lee, S.H. Pathology. (2006) [Pubmed]
  2. Endophilin B1 is required for the maintenance of mitochondrial morphology. Karbowski, M., Jeong, S.Y., Youle, R.J. J. Cell Biol. (2004) [Pubmed]
  3. Loss of Bif-1 suppresses Bax/Bak conformational change and mitochondrial apoptosis. Takahashi, Y., Karbowski, M., Yamaguchi, H., Kazi, A., Wu, J., Sebti, S.M., Youle, R.J., Wang, H.G. Mol. Cell. Biol. (2005) [Pubmed]
  4. Characterization of Endophilin B1b, a brain-specific membrane-associated lysophosphatidic acid acyl transferase with properties distinct from endophilin A1. Modregger, J., Schmidt, A.A., Ritter, B., Huttner, W.B., Plomann, M. J. Biol. Chem. (2003) [Pubmed]
  5. SH3GLB, a new endophilin-related protein family featuring an SH3 domain. Pierrat, B., Simonen, M., Cueto, M., Mestan, J., Ferrigno, P., Heim, J. Genomics (2001) [Pubmed]
  6. Molecular cloning and characterization of Bif-1. A novel Src homology 3 domain-containing protein that associates with Bax. Cuddeback, S.M., Yamaguchi, H., Komatsu, K., Miyashita, T., Yamada, M., Wu, C., Singh, S., Wang, H.G. J. Biol. Chem. (2001) [Pubmed]
  7. Endophilin B1/Bif-1 stimulates BAX activation independently from its capacity to produce large scale membrane morphological rearrangements. Etxebarria, A., Terrones, O., Yamaguchi, H., Landajuela, A., Landeta, O., Antonsson, B., Wang, H.G., Basañez, G. J. Biol. Chem. (2009) [Pubmed]
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