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Gene Review

ZMYND10  -  zinc finger, MYND-type containing 10

Homo sapiens

Synonyms: BLU, CILD22, FLU, LUCA12.4, Protein BLu, ...
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Disease relevance of ZMYND10


High impact information on ZMYND10


Biological context of ZMYND10


Anatomical context of ZMYND10


Associations of ZMYND10 with chemical compounds

  • When BLU/ZMYND10 is expressed in the absence of doxycycline, the stable transfectants were able to induce tumor suppression in nude mice [6].
  • Treatment of NPC cell lines with 5-aza-2'-deoxycytidine activated BLU expression along with promoter demethylation [5].
  • We illustrate and discuss when the BLUE or BLUP will be a better estimate of a subject's latent value given a single measure on a subject, concluding that the BLUP estimator should be routinely used for total cholesterol and per cent kcal from fat, with a modified BLUP estimator used for large observed values of leisure time activity [7].
  • The predicted genetic responses were calculated by studying the differences between the S and C lines in averaged values of five traits of the BLUP animal model [8].

Other interactions of ZMYND10


Analytical, diagnostic and therapeutic context of ZMYND10

  • Methylation specific PCR analysis revealed that the BLU promoter was highly methylated in 74% (17 of 23) of primary tumors in which BLU was downregulated, whereas only 2 of 9 non-neoplastic nasopharyngeal epithelia exhibited hypermethylation in the BLU promoter region [9].
  • Animals were evaluated with a conventional BLUP animal model or with a model using marker information [10].


  1. Epigenetic inactivation of the candidate 3p21.3 suppressor gene BLU in human cancers. Agathanggelou, A., Dallol, A., Zöchbauer-Müller, S., Morrissey, C., Honorio, S., Hesson, L., Martinsson, T., Fong, K.M., Kuo, M.J., Yuen, P.W., Maher, E.R., Minna, J.D., Latif, F. Oncogene (2003) [Pubmed]
  2. Allele loss and epigenetic inactivation of 3p21.3 in malignant liver tumors. Tischoff, I., Markwarth, A., Witzigmann, H., Uhlmann, D., Hauss, J., Mirmohammadsadegh, A., Wittekind, C., Hengge, U.R., Tannapfel, A. Int. J. Cancer (2005) [Pubmed]
  3. Expression of candidate chromosome 3p21.3 tumor suppressor genes and down-regulation of BLU in some esophageal squamous cell carcinomas. Yi Lo, P.H., Chung Leung, A.C., Xiong, W., Law, S., Duh, F.M., Lerman, M.I., Stanbridge, E.J., Lung, M.L. Cancer Lett. (2006) [Pubmed]
  4. CpG island methylator phenotype is a strong determinant of poor prognosis in neuroblastomas. Abe, M., Ohira, M., Kaneda, A., Yagi, Y., Yamamoto, S., Kitano, Y., Takato, T., Nakagawara, A., Ushijima, T. Cancer Res. (2005) [Pubmed]
  5. The candidate tumor suppressor gene BLU, located at the commonly deleted region 3p21.3, is an E2F-regulated, stress-responsive gene and inactivated by both epigenetic and genetic mechanisms in nasopharyngeal carcinoma. Qiu, G.H., Tan, L.K., Loh, K.S., Lim, C.Y., Srivastava, G., Tsai, S.T., Tsao, S.W., Tao, Q. Oncogene (2004) [Pubmed]
  6. Functional studies of the chromosome 3p21.3 candidate tumor suppressor gene BLU/ZMYND10 in nasopharyngeal carcinoma. Yau, W.L., Lung, H.L., Zabarovsky, E.R., Lerman, M.I., Sham, J.S., Chua, D.T., Tsao, S.W., Stanbridge, E.J., Lung, M.L. Int. J. Cancer (2006) [Pubmed]
  7. Why not routinely use best linear unbiased predictors (BLUPs) as estimates of cholesterol, per cent fat from kcal and physical activity? Stanek, E.J., Well, A., Ockene, I. Statistics in medicine. (1999) [Pubmed]
  8. Selection responses for the number of fertile eggs of the Brown Tsaiya duck (Anas platyrhynchos) after a single artificial insemination with pooled Muscovy (Cairina moschata) semen. Cheng, Y.S., Rouvier, R., Poivey, J.P., Tai, J.J., Tai, C., Huang, S.C. Genet. Sel. Evol. (2002) [Pubmed]
  9. Alterations of BLU, a candidate tumor suppressor gene on chromosome 3p21.3, in human nasopharyngeal carcinoma. Liu, X.Q., Chen, H.K., Zhang, X.S., Pan, Z.G., Li, A., Feng, Q.S., Long, Q.X., Wang, X.Z., Zeng, Y.X. Int. J. Cancer (2003) [Pubmed]
  10. Marker assisted selection for genetic improvement of animal populations when a single QTL is marked. Ruane, J., Colleau, J.J. Genet. Res. (1995) [Pubmed]
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