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Gene Review

ACP2  -  acid phosphatase 2, lysosomal

Homo sapiens

Synonyms: LAP, Lysosomal acid phosphatase
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Disease relevance of ACP2

  • Legionella micdadei cells contain an acid phosphatase (ACP2) which blocks superoxide anion production by human neutrophils stimulated with formyl-Met-Leu-Phe (fMLP) [A. K. Saha, et al. (1985) Arch. Biochem. Biophys. 243, 150-160] [1].

High impact information on ACP2

  • Two other cysteine proteinase genes (ACP2, ACP3) are 85% identical to each other and are present in both pathogenic and nonpathogenic isolates [2].
  • To determine whether it was possible to increase toxin sensitivity by increasing the rate of toxin internalization, we constructed diphtheria toxin cytoplasmic domain mutant cell lines containing rapid-internalization signals from either the low density lipoprotein receptor or from the lysosomal acid phosphatase precursor [3].
  • The results indicate that the presence of ACP 2 is essential for the synthesis of decanoic acid in C. lanceolata seeds, and its expression in the phase of accumulation of high levels of this fatty acid provides an additional and highly efficient cofactor for stimulating the FAS reaction [4].
  • Analysis of PCR amplifications, first from somatic cell hybrids and subsequently from radiation hybrids, localizes the human RAPSN gene locus to chromosome 11p11.2-p11.1 in close proximity to ACP2 [5].
  • Three human genes known between 11p11 and 11p13 (FSHB, CAT, ACP2) were on murine chromosome 2 [6].

Biological context of ACP2


Anatomical context of ACP2

  • Subsequent chromatography of ACP2 on a Sephadex G-150 column revealed coincident elution of phosphatase activity and neutrophil blocking activity [10].
  • Bone marrow (BM) cells from BALB/c mice were transduced in vitro with a retroviral construct containing green fluorescent protein (GFP) for detection and human LAP (hLAP) as a test molecule [11].

Associations of ACP2 with chemical compounds


Other interactions of ACP2


Analytical, diagnostic and therapeutic context of ACP2


  1. Legionella micdadei phosphatase catalyzes the hydrolysis of phosphatidylinositol 4,5-bisphosphate in human neutrophils. Saha, A.K., Dowling, J.N., Pasculle, A.W., Glew, R.H. Arch. Biochem. Biophys. (1988) [Pubmed]
  2. Cloning of a virulence factor of Entamoeba histolytica. Pathogenic strains possess a unique cysteine proteinase gene. Reed, S., Bouvier, J., Pollack, A.S., Engel, J.C., Brown, M., Hirata, K., Que, X., Eakin, A., Hagblom, P., Gillin, F. J. Clin. Invest. (1993) [Pubmed]
  3. The effect of receptor rapid-internalization signals on diphtheria toxin endocytosis and cell sensitivity. Almond, B.D., Eidels, L. Mol. Microbiol. (1995) [Pubmed]
  4. The role of acyl carrier protein isoforms from Cuphea lanceolata seeds in the de-novo biosynthesis of medium-chain fatty acids. Schütt, B.S., Brummel, M., Schuch, R., Spener, F. Planta (1998) [Pubmed]
  5. Cloning of cDNA encoding human rapsyn and mapping of the RAPSN gene locus to chromosome 11p11.2-p11.1. Buckel, A., Beeson, D., James, M., Vincent, A. Genomics (1996) [Pubmed]
  6. Localization of the human oncogene SPI1 on chromosome 11, region p11.22. Nguyen, V.C., Ray, D., Gross, M.S., de Tand, M.F., Frézal, J., Moreau-Gachelin, F. Hum. Genet. (1990) [Pubmed]
  7. Regional mapping of the gene for human lysosomal acid phosphatase (ACP2) using a hybrid clone panel containing segments of human chromosome 11. Jones, C., Kao, F.T. Hum. Genet. (1978) [Pubmed]
  8. Genetic polymorphism of rabbit (Oryctolagus cuniculus) tissue acid phosphatases (ACP2 and ACP3). Branco, M., Ferrand, N. Comp. Biochem. Physiol. B, Biochem. Mol. Biol. (1998) [Pubmed]
  9. Acid phosphatase polymorphism in European shad (Fish: Clupeids). Castro, F., Linhares, D., Alexandrino, P. Biochem. Genet. (1999) [Pubmed]
  10. Properties of an acid phosphatase from Legionella micdadei which blocks superoxide anion production by human neutrophils. Saha, A.K., Dowling, J.N., LaMarco, K.L., Das, S., Remaley, A.T., Olomu, N., Pope, M.T., Glew, R.H. Arch. Biochem. Biophys. (1985) [Pubmed]
  11. Transduced monocyte/macrophages targeted to murine skin by UV light. Zhang, A.Y., Wu, C., Zhou, L., Ismail, S.A., Tao, J., McCormick, L.L., Cooper, K.D., Gilliam, A.C. Exp. Dermatol. (2006) [Pubmed]
  12. Structural characterization of room-temperature synthesized nano-sized beta-tricalcium phosphate. Bow, J.S., Liou, S.C., Chen, S.Y. Biomaterials (2004) [Pubmed]
  13. Effects of NaCI stress on nitrogen and phosphorous metabolism in a true mangrove Bruguiera parviflora grown under hydroponic culture. Parida, A.K., Das, A.B. J. Plant Physiol. (2004) [Pubmed]
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