Disease relevance of calcium hydroxy-dioxido-oxo-phosphorane

• The development of secondary hyperparathyroidism in uremia is thought to be due, in part, to the retention of inorganic phosphate which, as proposed by the "trade-off hypothesis", lowers serum ionized calcium by means of CaHPO4 complex formation [1].
• Comparable dietary phosphorus from precipitated bone and the soft-precipitated mixture supported body weights statistically equivalent to those of dicalcium phosphate treatments [2].
• Inactivation of transmissible spongiform encephalopathy agents during the manufacture of dicalcium phosphate from bone [3].
• Effects of sweets supplemented with dicalcium phosphate on dental plaque composition [4].
• Toxicity of excess dicalcium phosphate in the diet of turkey poults [5].

High impact information on calcium hydroxy-dioxido-oxo-phosphorane

• The rate of precipitation of CaHPO4 was retarded by mucin and CBP [6].
• The compensatory proliferation of the colonic epithelium was decreased by supplemental CaHPO4 for the butter and saturated margarine diets [7].
• When a dietary supplement of dibasic calcium phosphate was given to diabetic subjects for 28 days, a significant increase in P50 also occurred (25.2 vs. 27.2 mm. Hg, P less than 0.001) [8].
• In the in vivo studies, the mean thyroid uptake at 1 h for sodium phosphate dibasic powder with 1% magnesium stearate (complete-release formulation) was 12.7%, compared with 9.3% for calcium phosphate dibasic powder with 3% magnesium stearate (incomplete-release formulation) (P < 0.05) [9].
• These results indicate that an increase in serum inorganic phosphate to as great as 1 mM/liter does not produce a fall in serum ionized calcium by means of direct physicochemical CaHPO4 complex formation great enough to account for the development of secondary hyperparathyroidism [1].

Chemical compound and disease context of calcium hydroxy-dioxido-oxo-phosphorane

• Hypercalciuria and postglomerular hematuria in children. The effects of thiazide on calcium excretion, urine saturation with respect to calcium-hydrogenphosphate and hematuria [10].

Biological context of calcium hydroxy-dioxido-oxo-phosphorane

• The hydrolysis experiments (1 mmol to 7.5 mmol CaHPO4/250 mL) were carried out under CO2-free N2 at fixed pH in the presence of 25-100 mmol/L CaCl2 by standard pH-stat techniques at 37 degrees C. The pH values of the experimental solutions ranged from 6.35 to 9 [11].
• The seeded growth of calcium phosphates. The kinetics of growth of dicalcium phosphate dihydrate on enamel, dentin, and calculus [12].
• Bioavailability of P from defluorinated phosphate and dicalcium phosphate and the P requirement were studied with 63 male Holstein calves [13].
• In the third study, with CaHPO4 as the vehicle for Ca supplementation, blood pressure was consistently reduced in rats after 8 weeks on the high Ca diet [14].
• Lactation dietary P levels ranged from .50 to .90% in .10% increments with Ca concurrently increased in a 1.3:1 ratio using dicalcium phosphate and limestone as the inorganic mineral sources [15].

Anatomical context of calcium hydroxy-dioxido-oxo-phosphorane

• Bone tissue response to pre-hardened alpha-tricalcium phosphate (alpha-TCP) and calcium phosphate dibasic (DCPD) mixture by hydration was studied histologically and microradiographically after implanting on the inferior aspect of the mandible in rabbits [16].
• After three months immersion in a simulated body fluid, the growth of calcium phosphate species containing both HPO4- and H2PO4- (probably CaHPO4 and Ca(HPO4)2) have been observed [17].
• In two sets of experiments, glutaraldehyde-treated BP membranes were placed between two compartments, both of which contained calcium phosphate solutions made by equilibration of octacalcium phosphate (Exp I) or dicalcium phosphate dihydrate (Exp II) in phosphoric acid [18].
• However, a control group of chicks fed 0.70% calcium from limestone and dicalcium phosphate did not grow as well as the others and had lower weights of tibia and tibial bone ash, calcium, and phosphorus compared to the others [19].
• Small sintered dicalcium phosphate particles can inhibit the proliferation of the osteoblasts [20].

Associations of calcium hydroxy-dioxido-oxo-phosphorane with other chemical compounds

• At concentrations below these values, statherin inhibited spontaneous precipitation of calcium phosphate salts from an assay system which was more supersaturated with respect to dicalcium phosphate dihydrate, and comparably supersaturated with respect to hydroxyapatite, than were human saliva samples [21].
• Two steady-state pH conditions occurred during the second stage as TetCP reacted with DCPD and DCP [22].
• In a double-blind, paired-comparison, placebo-controlled study, the diet of 10 healthy female volunteers, aged 20-22 yr, was supplemented for a period of 7 wk with 7.5 g sodium propionate daily in capsule form, while the diet of the 10 control group members was supplemented with dibasic calcium phosphate in identical capsules as placebo [23].
• Lactose, dicalcium phosphate dihydrate, and sorbitol, alone or in combination, provided varying degrees of solubility and hygroscopicity to the direct compression tablet formulations [24].
• In 18 rabbits we investigated the influence of a dicalcium phosphate (DCPD) coating, or of a growth and differentiation factor-5 (GDF-5) coating, or a combination of both on the stability of titanium implants [25].

Gene context of calcium hydroxy-dioxido-oxo-phosphorane

• The phase evolution from CaHPO4, intermediate amorphous calcium phosphate (ACP) phases (including ACP1 and ACP2 with different structures) to final beta-TCP with increasing aging time was observed [26].
• The setting reactions of calcium phosphate cements in the CaHPO4-alpha-Ca3(PO4)2 (DCP-alpha-TCP) system have been investigated [27].
• The powder phase of CP-1 was an equimolar mixture of tetracalcium phosphate and dicalcium phosphate dihydrate, and that of CP-2 was alpha-tricalcium phosphate [28].
• In the study, hexamethylene diisocyanate (HMDI) was used as coupling agent and calcium hydrogenphosphate (CaHPO4, CHP) was the candidate ceramic [29].
• Three techniques were used to compare the time-dependent deformation of microfine cellulose (Elcema G250), anhydrous lactose, dicalcium phosphate dihydrate (Emcompress), modified starch (Sta-Rx 1500) and sodium chloride [30].

Analytical, diagnostic and therapeutic context of calcium hydroxy-dioxido-oxo-phosphorane

• The effects of the proteins on precipitation of CaHPO4 were assessed by nephelometry and gravimetry [6].
• In addition, the setting reaction of a calcium phosphate cement (CPC) consisting of an equimolar mixture of TTCP and dicalcium phosphate (DCPA) was investigated by Raman spectroscopy [31].
• Animals were maintained in the litters with the mother rats and supplemented with 1%, 3% or 6% calcium (as CaHPO4 x 2H2O) in cow's milk by artificial feeding from day of birth 6 through 14 [32].
• Chemical fractionation showed that H2O-extractable P was the predominant form in broiler litter (56-77%), whereas aqueous phosphate determined with XANES was <18% indicating that H2O probably dissolved mineral forms of P (e.g., dicalcium phosphate) [33].
• Only below this level did CaHPO4 become visible in infrared spectrophotometry analysis [34].

References