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Chemical Compound Review

Biofos     calciumhydroxy-dioxido-oxo- phosphorane

Synonyms: A-Tab, CaHPO4, Fujicalin S, Dicafos AN, Ipifosc 20, ...
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Disease relevance of calcium hydroxy-dioxido-oxo-phosphorane


High impact information on calcium hydroxy-dioxido-oxo-phosphorane


Chemical compound and disease context of calcium hydroxy-dioxido-oxo-phosphorane


Biological context of calcium hydroxy-dioxido-oxo-phosphorane

  • The hydrolysis experiments (1 mmol to 7.5 mmol CaHPO4/250 mL) were carried out under CO2-free N2 at fixed pH in the presence of 25-100 mmol/L CaCl2 by standard pH-stat techniques at 37 degrees C. The pH values of the experimental solutions ranged from 6.35 to 9 [11].
  • The seeded growth of calcium phosphates. The kinetics of growth of dicalcium phosphate dihydrate on enamel, dentin, and calculus [12].
  • Bioavailability of P from defluorinated phosphate and dicalcium phosphate and the P requirement were studied with 63 male Holstein calves [13].
  • In the third study, with CaHPO4 as the vehicle for Ca supplementation, blood pressure was consistently reduced in rats after 8 weeks on the high Ca diet [14].
  • Lactation dietary P levels ranged from .50 to .90% in .10% increments with Ca concurrently increased in a 1.3:1 ratio using dicalcium phosphate and limestone as the inorganic mineral sources [15].

Anatomical context of calcium hydroxy-dioxido-oxo-phosphorane

  • Bone tissue response to pre-hardened alpha-tricalcium phosphate (alpha-TCP) and calcium phosphate dibasic (DCPD) mixture by hydration was studied histologically and microradiographically after implanting on the inferior aspect of the mandible in rabbits [16].
  • After three months immersion in a simulated body fluid, the growth of calcium phosphate species containing both HPO4- and H2PO4- (probably CaHPO4 and Ca(HPO4)2) have been observed [17].
  • In two sets of experiments, glutaraldehyde-treated BP membranes were placed between two compartments, both of which contained calcium phosphate solutions made by equilibration of octacalcium phosphate (Exp I) or dicalcium phosphate dihydrate (Exp II) in phosphoric acid [18].
  • However, a control group of chicks fed 0.70% calcium from limestone and dicalcium phosphate did not grow as well as the others and had lower weights of tibia and tibial bone ash, calcium, and phosphorus compared to the others [19].
  • Small sintered dicalcium phosphate particles can inhibit the proliferation of the osteoblasts [20].

Associations of calcium hydroxy-dioxido-oxo-phosphorane with other chemical compounds

  • At concentrations below these values, statherin inhibited spontaneous precipitation of calcium phosphate salts from an assay system which was more supersaturated with respect to dicalcium phosphate dihydrate, and comparably supersaturated with respect to hydroxyapatite, than were human saliva samples [21].
  • Two steady-state pH conditions occurred during the second stage as TetCP reacted with DCPD and DCP [22].
  • In a double-blind, paired-comparison, placebo-controlled study, the diet of 10 healthy female volunteers, aged 20-22 yr, was supplemented for a period of 7 wk with 7.5 g sodium propionate daily in capsule form, while the diet of the 10 control group members was supplemented with dibasic calcium phosphate in identical capsules as placebo [23].
  • Lactose, dicalcium phosphate dihydrate, and sorbitol, alone or in combination, provided varying degrees of solubility and hygroscopicity to the direct compression tablet formulations [24].
  • In 18 rabbits we investigated the influence of a dicalcium phosphate (DCPD) coating, or of a growth and differentiation factor-5 (GDF-5) coating, or a combination of both on the stability of titanium implants [25].

Gene context of calcium hydroxy-dioxido-oxo-phosphorane

  • The phase evolution from CaHPO4, intermediate amorphous calcium phosphate (ACP) phases (including ACP1 and ACP2 with different structures) to final beta-TCP with increasing aging time was observed [26].
  • The setting reactions of calcium phosphate cements in the CaHPO4-alpha-Ca3(PO4)2 (DCP-alpha-TCP) system have been investigated [27].
  • The powder phase of CP-1 was an equimolar mixture of tetracalcium phosphate and dicalcium phosphate dihydrate, and that of CP-2 was alpha-tricalcium phosphate [28].
  • In the study, hexamethylene diisocyanate (HMDI) was used as coupling agent and calcium hydrogenphosphate (CaHPO4, CHP) was the candidate ceramic [29].
  • Three techniques were used to compare the time-dependent deformation of microfine cellulose (Elcema G250), anhydrous lactose, dicalcium phosphate dihydrate (Emcompress), modified starch (Sta-Rx 1500) and sodium chloride [30].

Analytical, diagnostic and therapeutic context of calcium hydroxy-dioxido-oxo-phosphorane


  1. Effect of inorganic phosphate on serum ionized calcium concentration in vitro: a reassessment of the "trade-off hypothesis". Adler, A.J., Ferran, N., Berlyne, G.M. Kidney Int. (1985) [Pubmed]
  2. Precipitated bone phosphate in broiler chick diets. Damron, B.L., Flunker, L.K. Poult. Sci. (1988) [Pubmed]
  3. Inactivation of transmissible spongiform encephalopathy agents during the manufacture of dicalcium phosphate from bone. Grobben, A.H., Steele, P.J., Somerville, R.A., Taylor, D.M. Vet. Rec. (2006) [Pubmed]
  4. Effects of sweets supplemented with dicalcium phosphate on dental plaque composition. Ashley, F.P., Wilson, R.F. Caries Res. (1977) [Pubmed]
  5. Toxicity of excess dicalcium phosphate in the diet of turkey poults. Wallner-Pendleton, E.A., Hedstrom, O., Savage, T.F., Nakaue, H.S. Avian Dis. (1989) [Pubmed]
  6. Interaction of bovine gallbladder mucin and calcium-binding protein: effects on calcium phosphate precipitation. Afdhal, N.H., Ostrow, J.D., Koehler, R., Niu, N., Groen, A.K., Veis, A., Nunes, D.P., Offner, G.D. Gastroenterology (1995) [Pubmed]
  7. The antiproliferative effect of dietary calcium on colonic epithelium is mediated by luminal surfactants and dependent on the type of dietary fat. Lapré, J.A., De Vries, H.T., Koeman, J.H., Van der Meer, R. Cancer Res. (1993) [Pubmed]
  8. Oxygen transport impairment in diabetes. Ditzel, J. Diabetes (1976) [Pubmed]
  9. The effect of formulation on reduced radioiodide thyroid uptake. Yu, M.D., Huang, W.S., Cherng, C.C., Shaw, S.M. J. Nucl. Med. (2002) [Pubmed]
  10. Hypercalciuria and postglomerular hematuria in children. The effects of thiazide on calcium excretion, urine saturation with respect to calcium-hydrogenphosphate and hematuria. Reusz, G., Szabó, A. Acta paediatrica Hungarica. (1990) [Pubmed]
  11. The hydrolysis of anhydrous dicalcium phosphate into hydroxyapatite. Ishikawa, K., Eanes, E.D. J. Dent. Res. (1993) [Pubmed]
  12. The seeded growth of calcium phosphates. The kinetics of growth of dicalcium phosphate dihydrate on enamel, dentin, and calculus. Barone, J.P., Nancollas, G.H. J. Dent. Res. (1978) [Pubmed]
  13. Bioavailability of phosphorus from defluorinated and dicalcium phosphates and phosphorus requirement of calves. Miller, W.J., Neathery, M.W., Gentry, R.P., Blackmon, D.M., Crowe, C.T., Ware, G.O., Fielding, A.S. J. Dairy Sci. (1987) [Pubmed]
  14. Hypotensive effect of a high calcium diet in the Wistar rat. Jones, M.R., Ghaffari, F., Tomerson, B.W., Clemens, R.A. Mineral and electrolyte metabolism. (1986) [Pubmed]
  15. Dietary calcium and phosphorus for lactating swine at high and average production levels. Maxson, P.F., Mahan, D.C. J. Anim. Sci. (1986) [Pubmed]
  16. Histological and microradiographic evaluation of hydrated and hardened alpha-tricalcium phosphate/calcium phosphate dibasic mixtures. Kurashina, K., Ogiso, A., Kotani, A., Takeuchi, H., Hirano, M. Biomaterials (1994) [Pubmed]
  17. Surface characterization of C/Ti-6Al-4V coating treated with ion beam. Demri, B., Hage-Ali, M., Moritz, M., Muster, D. Biomaterials (1997) [Pubmed]
  18. An in vitro diffusion model for the study of calcification of bovine pericardium tissue. Tomazic, B.B., Chow, L.C., Carey, C.M., Shapiro, A.J. Journal of pharmaceutical sciences. (1997) [Pubmed]
  19. An investigation of calcium citrate-malate as a calcium source for young broiler chicks. Henry, M.H., Pesti, G.M. Poult. Sci. (2002) [Pubmed]
  20. The effect of sintered beta-dicalcium pyrophosphate particle size on newborn Wistar rat osteoblasts. Sun, J.S., Tsuang, Y.H., Liao, C.J., Liu, H.C., Hang, Y.S., Lin, F.H. Artificial organs. (1999) [Pubmed]
  21. Relationship between concentration of human salivary statherin and inhibition of calcium phosphate precipitation in stimulated human parotid saliva. Hay, D.I., Smith, D.J., Schluckebier, S.K., Moreno, E.C. J. Dent. Res. (1984) [Pubmed]
  22. The formation of hydroxyapatite-ionomer cements at 38 degrees C. TenHuisen, K.S., Brown, P.W. J. Dent. Res. (1994) [Pubmed]
  23. Effects of dietary propionate on carbohydrate and lipid metabolism in healthy volunteers. Venter, C.S., Vorster, H.H., Cummings, J.H. Am. J. Gastroenterol. (1990) [Pubmed]
  24. Effect of tablet solubility and hygroscopicity on disintegrant efficiency in direct compression tablets in terms of dissolution. Gordon, M.S., Chowhan, Z.T. Journal of pharmaceutical sciences. (1987) [Pubmed]
  25. The influence of surface coatings of dicalcium phosphate (DCPD) and growth and differentiation factor-5 (GDF-5) on the stability of titanium implants in vivo. Simank, H.G., Stuber, M., Frahm, R., Helbig, L., van Lenthe, H., Müller, R. Biomaterials (2006) [Pubmed]
  26. Structural characterization of room-temperature synthesized nano-sized beta-tricalcium phosphate. Bow, J.S., Liou, S.C., Chen, S.Y. Biomaterials (2004) [Pubmed]
  27. The cement setting reaction in the CaHPO4-alpha-Ca3(PO4)2 system: an X-ray diffraction study. Fernández, E., Gil, F.J., Best, S., Ginebra, M.P., Driessens, F.C., Planell, J.A. J. Biomed. Mater. Res. (1998) [Pubmed]
  28. Reconstruction of alveolar bone defect by calcium phosphate compounds. Yoshikawa, M., Toda, T. J. Biomed. Mater. Res. (2000) [Pubmed]
  29. A study on grafting and characterization of HMDI-modified calcium hydrogenphosphate. Dong, G.C., Sun, J.S., Yao, C.H., Jiang, G.J., Huang, C.W., Lin, F.H. Biomaterials (2001) [Pubmed]
  30. Time-dependent deformation of some direct compression excipients. Rees, J.E., Rue, P.J. J. Pharm. Pharmacol. (1978) [Pubmed]
  31. Vibrational spectroscopic study of tetracalcium phosphate in pure polycrystalline form and as a constituent of a self-setting bone cement. Posset, U., Löcklin, E., Thull, R., Kiefer, W. J. Biomed. Mater. Res. (1998) [Pubmed]
  32. Effect of dietary calcium on cadmium absorption and retention in suckling rats. Sarić, M.M., Blanusa, M., Piasek, M., Varnai, V.M., Juresa, D., Kostial, K. Biometals (2002) [Pubmed]
  33. Phosphorus speciation in broiler litter and turkey manure produced from modified diets. Toor, G.S., Peak, J.D., Sims, J.T. J. Environ. Qual. (2005) [Pubmed]
  34. The composition of urinary stones analysed by infrared spectrophotometry and the precipitation of calcium phosphates from saturated solutions. Try, K. Scandinavian journal of urology and nephrology. (1981) [Pubmed]
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