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Gene Review

Acph-1  -  Acid phosphatase 1

Drosophila melanogaster

Synonyms: ACP, ACPH, APH, Acph, CG7899, ...
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High impact information on Acph-1


Biological context of Acph-1

  • Strong genetic differentiation at Acph-1 was detected among the different arrangements, which is reflected in strong linkage disequilibrium between the variants at informative polymorphic sites and the type of arrangement [5].
  • The pattern of variation at Acph-1 within the young arrangements is unusual for nuclear genes and has the same characteristics previously detected in most genes of the mitochondrial genome [5].
  • Lines differ in their chromosomal arrangement for segment I of the O chromosome (O(st) and O(3+4)) and in the Acph-1 electrophoretic allele (Acph-1(100), Acph-1(054), and Acph-1(>100)) [6].
  • Amino acid sequence comparisons have revealed several highly conserved motifs between Drosophila Acph-1 and vertebrate lysosomal and prostatic acid phosphatases [7].
  • We have isolated and purified two parental homodimers and a unique heterodimer of acid phosphatase [coded by Acph-1 (1.05)(F) and Acph-1 (0.95)(S)] from isogenic homozygotes and heterozygotes of Drosophila malerkotliana [8].

Anatomical context of Acph-1


Associations of Acph-1 with chemical compounds


Other interactions of Acph-1


Analytical, diagnostic and therapeutic context of Acph-1


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  2. Purification and characterization of acid phosphatase-1 from Drosophila melanogaster. Feigen, M.I., Johns, M.A., Postlethwait, J.H., Sederoff, R.R. J. Biol. Chem. (1980) [Pubmed]
  3. Structural and histochemical studies of Golgi complex differentiation in salivary gland cells during Drosophila development. Thomopoulos, G.N., Neophytou, E.P., Alexiou, M., Vadolas, A., Limberi-Thomopoulos, S., Derventzi, A. J. Cell. Sci. (1992) [Pubmed]
  4. Combined histochemical and x-ray microanalytical studies on the copper-accumulating granules in the mid-gut of larval Drosophila. Tapp, R.L., Hockaday, A. J. Cell. Sci. (1977) [Pubmed]
  5. Excess of nonsynonymous polymorphism at Acph-1 in different gene arrangements of Drosophila subobscura. Navarro-Sabaté, A., Aguadé, M., Segarra, C. Mol. Biol. Evol. (2003) [Pubmed]
  6. The relationship between allozyme and chromosomal polymorphism inferred from nucleotide variation at the Acph-1 gene region of Drosophila subobscura. Navarro-Sabaté, A., Aguadé, M., Segarra, C. Genetics (1999) [Pubmed]
  7. Molecular characterization of the lysosomal acid phosphatase from Drosophila melanogaster. Chung, H.J., Shaffer, C., MacIntyre, R. Mol. Gen. Genet. (1996) [Pubmed]
  8. Epigenetics of dominance for enzyme activity. Trehan, K.S., Gill, K.S. J. Biosci. (2002) [Pubmed]
  9. Hereditary retinal degeneration in Drosophila melanogaster. A mutant defect associated with the phototransduction process. Harris, W.A., Stark, W.S. J. Gen. Physiol. (1977) [Pubmed]
  10. Ultrastructural histochemical localization of acid phosphatase in salivary glands of Drosophila melanogaster. Anastasia-Sawicki, J., MacIntyre, R.J. J. Histochem. Cytochem. (1976) [Pubmed]
  11. Atypical granules in the eyes of the white mutant of Drosophila melanogaster are lysosome-related organelles. Schraermeyer, U., Dohms, M. Pigment Cell Res. (1993) [Pubmed]
  12. Lipid composition of subcellular membranes from larvae and prepupae of Drosophila melanogaster. Jones, H.E., Harwood, J.L., Bowen, I.D., Griffiths, G. Lipids (1992) [Pubmed]
  13. Localized cell death in Drosophila imaginal wing disc epithelium caused by the mutation apterous-blot. Sedlak, B.J., Manzo, R., Stevens, M. Dev. Biol. (1984) [Pubmed]
  14. Comparison of purified acid phosphatase allozymes in Drosophila virilis: differences in carbohydrate content and composition of the allozymes. Narise, S., Tominaga, H. Biochem. Genet. (1987) [Pubmed]
  15. A histochemical study of the muscles of Drosophila melanogaster. Deak, I.I. J. Morphol. (1977) [Pubmed]
  16. Nucleotide variation at the yellow gene region is not reduced in Drosophila subobscura: a study in relation to chromosomal polymorphism. Munté, A., Aguadé, M., Segarra, C. Mol. Biol. Evol. (2000) [Pubmed]
  17. Synchronous allelic expression at esterase & acid phosphatase loci in interspecific Drosophila hybrids. Parkash, R., Jain, S. Indian J. Exp. Biol. (1982) [Pubmed]
  18. Localization of genes coding for biochemical traits on the second chromosome of Drosophila imeretensis Sokolov (D. littoralis Meigen). Gontcharenko, G.G., Mitrofanov, V.G., Korochkin, L.I. Biochem. Genet. (1985) [Pubmed]
  19. Position effect variegation of an acid phosphatase gene in Drosophila melanogaster. Frisardi, M.C., MacIntyre, R.J. Mol. Gen. Genet. (1984) [Pubmed]
  20. Naturally occurring quantitative variants of acid phosphatase-1 in Drosophila melanogaster. Johns, M.A., Postlethwait, J.H. Biochem. Genet. (1985) [Pubmed]
  21. Molecular cloning, sequencing and alternative splicing of the acid phosphatase (Acph) gene from Drosophila virilis. Kitagawa, H.T. DNA Seq. (2003) [Pubmed]
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