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Gene Review

Rab11a  -  RAB11A, member RAS oncogene family

Mus musculus

Synonyms: Rab-11, Rab11, Ras-related protein Rab-11A
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Disease relevance of Rab11a


High impact information on Rab11a


Biological context of Rab11a


Anatomical context of Rab11a


Co-localisations of Rab11a

  • In contrast, Rab11 colocalized with V-ATPase in apical regions of proximal tubule, and Rab20 colocalized with the enzyme in intercalated cells [8].

Regulatory relationships of Rab11a

  • Knocking out RhoB or expressing a dominant-interfering Rab11 mutant suppresses both catalytic activation of Src and translocation of active kinase to peripheral membrane structures [9].

Other interactions of Rab11a

  • While recent work on Rab11a and Rab25 has yielded some insights into their function, Rab11b has received little attention [6].
  • Light microscopy and fractionation studies reveal that MR colocalizes predominantly with Rab5a and partially with Rab11, an endosomal recycling pathway marker [10].
  • Although we found close apposition between LDs and endosomal compartments labeled by expressed Rab5, Rab7, or Rab11 constructs, there was no detectable labeling of the LD surface itself by these Rab proteins [11].
  • ACRP30 is secreted from 3T3-L1 adipocytes via a Rab11-dependent pathway [12].
  • Using the antibody, Rab11 p24 was shown to be abundant in rat pancreas as well as in most rat tissues [13].


  1. c-Fos-dependent induction of the small ras-related GTPase Rab11a in skin carcinogenesis. Gebhardt, C., Breitenbach, U., Richter, K.H., Fürstenberger, G., Mauch, C., Angel, P., Hess, J. Am. J. Pathol. (2005) [Pubmed]
  2. Mouse polyomavirus enters early endosomes, requires their acidic pH for productive infection, and meets transferrin cargo in Rab11-positive endosomes. Liebl, D., Difato, F., Horníková, L., Mannová, P., Stokrová, J., Forstová, J. J. Virol. (2006) [Pubmed]
  3. A Rab11-containing rapidly recycling compartment in macrophages that promotes phagocytosis. Cox, D., Lee, D.J., Dale, B.M., Calafat, J., Greenberg, S. Proc. Natl. Acad. Sci. U.S.A. (2000) [Pubmed]
  4. Phosphatidylinositol 3-phosphate [PtdIns3P] is generated at the plasma membrane by an inositol polyphosphate 5-phosphatase: endogenous PtdIns3P can promote GLUT4 translocation to the plasma membrane. Kong, A.M., Horan, K.A., Sriratana, A., Bailey, C.G., Collyer, L.J., Nandurkar, H.H., Shisheva, A., Layton, M.J., Rasko, J.E., Rowe, T., Mitchell, C.A. Mol. Cell. Biol. (2006) [Pubmed]
  5. Genomic structure of murine Rab11 family members. Bhartur, S.G., Calhoun, B.C., Woodrum, J., Kurkjian, J., Iyer, S., Lai, F., Goldenring, J.R. Biochem. Biophys. Res. Commun. (2000) [Pubmed]
  6. Rab11b resides in a vesicular compartment distinct from Rab11a in parietal cells and other epithelial cells. Lapierre, L.A., Dorn, M.C., Zimmerman, C.F., Navarre, J., Burnette, J.O., Goldenring, J.R. Exp. Cell Res. (2003) [Pubmed]
  7. Rab11-FIP2, an adaptor protein connecting cellular components involved in internalization and recycling of epidermal growth factor receptors. Cullis, D.N., Philip, B., Baleja, J.D., Feig, L.A. J. Biol. Chem. (2002) [Pubmed]
  8. Distribution of Rab GTPases in mouse kidney and comparison with vacuolar H+-ATPase. Curtis, L.M., Gluck, S. Nephron. Physiology [electronic resource]. (2005) [Pubmed]
  9. RhoB and actin polymerization coordinate Src activation with endosome-mediated delivery to the membrane. Sandilands, E., Cans, C., Fincham, V.J., Brunton, V.G., Mellor, H., Prendergast, G.C., Norman, J.C., Superti-Furga, G., Frame, M.C. Dev. Cell (2004) [Pubmed]
  10. IL4/PGE2 induction of an enlarged early endosomal compartment in mouse macrophages is Rab5-dependent. Wainszelbaum, M.J., Proctor, B.M., Pontow, S.E., Stahl, P.D., Barbieri, M.A. Exp. Cell Res. (2006) [Pubmed]
  11. Regulated localization of Rab18 to lipid droplets: effects of lipolytic stimulation and inhibition of lipid droplet catabolism. Martin, S., Driessen, K., Nixon, S.J., Zerial, M., Parton, R.G. J. Biol. Chem. (2005) [Pubmed]
  12. ACRP30 is secreted from 3T3-L1 adipocytes via a Rab11-dependent pathway. Clarke, M., Ewart, M.A., Santy, L.C., Prekeris, R., Gould, G.W. Biochem. Biophys. Res. Commun. (2006) [Pubmed]
  13. Possible involvement of Rab11 p24, a Ras-like small GTP-binding protein, in intracellular vesicular transport of isolated pancreatic acini. Hori, Y., Takeyama, Y., Hiroyoshi, M., Ueda, T., Maeda, A., Ohyanagi, H., Saitoh, Y., Kaibuchi, K., Takai, Y. Dig. Dis. Sci. (1996) [Pubmed]
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